A highly efficient synthetic route to polysubstituted 2 H -chromenes was developed utilizing a domino O-alkylation/intramolecular Horner-Wadsworth-Emmons (HWE) olefination of diarylmethylphosphonates, which were readily accessed via Lewis acid mediated one-pot three-component coupling of aldehydes, phenols, and triethyl phosphite.
Bibliographical noteFunding Information:
We thank the National Research Foundation of Korea (NRF-2018R1A6A1A03023718 and NRF-2020R1A2C2005961) for generous financial support.National ReeachFoundatonofKoeaNRF2018R1A6A1A03023718National ReseachFoundaionofKoea(NRF2020R1A2C2005961)
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All Science Journal Classification (ASJC) codes
- Organic Chemistry