Facile Access to 3,4-Disubstituted 2 H -Chromenes via Domino [4+2] Annulation

Sure Siva Prasad; Dirgha Raj Joshi; Ikyon Kim

doi:10.1055/s-0040-1706089

Facile Access to 3,4-Disubstituted 2 H -Chromenes via Domino [4+2] Annulation

Sure Siva Prasad, Dirgha Raj Joshi, Ikyon Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A highly efficient synthetic route to polysubstituted 2 H -chromenes was developed utilizing a domino O-alkylation/intramolecular Horner-Wadsworth-Emmons (HWE) olefination of diarylmethylphosphonates, which were readily accessed via Lewis acid mediated one-pot three-component coupling of aldehydes, phenols, and triethyl phosphite.

Original language	English
Pages (from-to)	1503-1512
Number of pages	10
Journal	Synthesis (Germany)
Volume	53
Issue number	8
DOIs	https://doi.org/10.1055/s-0040-1706089
Publication status	Published - 2021 Apr 20

Bibliographical note

Funding Information:
We thank the National Research Foundation of Korea (NRF-2018R1A6A1A03023718 and NRF-2020R1A2C2005961) for generous financial support.National ReeachFoundatonofKoeaNRF2018R1A6A1A03023718National ReseachFoundaionofKoea(NRF2020R1A2C2005961)

Publisher Copyright:
© 2021 Georg Thieme Verlag. All rights reserved.

All Science Journal Classification (ASJC) codes

Catalysis
Organic Chemistry

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abstract = "A highly efficient synthetic route to polysubstituted 2 H -chromenes was developed utilizing a domino O-alkylation/intramolecular Horner-Wadsworth-Emmons (HWE) olefination of diarylmethylphosphonates, which were readily accessed via Lewis acid mediated one-pot three-component coupling of aldehydes, phenols, and triethyl phosphite.",

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doi = "10.1055/s-0040-1706089",

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AU - Kim, Ikyon

N1 - Funding Information: We thank the National Research Foundation of Korea (NRF-2018R1A6A1A03023718 and NRF-2020R1A2C2005961) for generous financial support.National ReeachFoundatonofKoeaNRF2018R1A6A1A03023718National ReseachFoundaionofKoea(NRF2020R1A2C2005961) Publisher Copyright: © 2021 Georg Thieme Verlag. All rights reserved.

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Y1 - 2021/4/20

N2 - A highly efficient synthetic route to polysubstituted 2 H -chromenes was developed utilizing a domino O-alkylation/intramolecular Horner-Wadsworth-Emmons (HWE) olefination of diarylmethylphosphonates, which were readily accessed via Lewis acid mediated one-pot three-component coupling of aldehydes, phenols, and triethyl phosphite.

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Facile Access to 3,4-Disubstituted 2 H -Chromenes via Domino [4+2] Annulation

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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