Facile and highly efficient N-formylation of amines using a catalytic amount of iodine under solvent-free conditions

Joong Gon Kim; Doo Ok Jang

doi:10.1055/s-0030-1258518

Facile and highly efficient N-formylation of amines using a catalytic amount of iodine under solvent-free conditions

Joong Gon Kim, Doo Ok Jang

Chemistry and Medical Chemistry

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

We developed a simple, practical, and catalytic method for the N-formylation of a wide variety of amines in the presence of molecular iodine as a catalyst under solvent-free conditions. This reaction is applicable to the chemoselective N-formylation of amino groups and -amino acid esters without epimerization.

Original language	English
Article number	U04610ST
Pages (from-to)	2093-2096
Number of pages	4
Journal	Synlett
Issue number	14
DOIs	https://doi.org/10.1055/s-0030-1258518
Publication status	Published - 2010

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1055/s-0030-1258518

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abstract = "We developed a simple, practical, and catalytic method for the N-formylation of a wide variety of amines in the presence of molecular iodine as a catalyst under solvent-free conditions. This reaction is applicable to the chemoselective N-formylation of amino groups and -amino acid esters without epimerization.",

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