Facile and highly efficient N-formylation of amines using a catalytic amount of iodine under solvent-free conditions

Joong Gon Kim, Doo Ok Jang

Research output: Contribution to journal › Article

46 Citations (Scopus)

Abstract

We developed a simple, practical, and catalytic method for the N-formylation of a wide variety of amines in the presence of molecular iodine as a catalyst under solvent-free conditions. This reaction is applicable to the chemoselective N-formylation of amino groups and -amino acid esters without epimerization.

Original languageEnglish
Article numberU04610ST
Pages (from-to)2093-2096
Number of pages4
JournalSynlett
Issue number14
DOIs
Publication statusPublished - 2010 Sep 1

Fingerprint

Iodine
Amines
Esters
Amino Acids
Catalysts

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Kim, Joong Gon ; Jang, Doo Ok. / Facile and highly efficient N-formylation of amines using a catalytic amount of iodine under solvent-free conditions. In: Synlett. 2010 ; No. 14. pp. 2093-2096.
@article{6fa438fd0e4e4dafbde5375149580d4a,
title = "Facile and highly efficient N-formylation of amines using a catalytic amount of iodine under solvent-free conditions",
abstract = "We developed a simple, practical, and catalytic method for the N-formylation of a wide variety of amines in the presence of molecular iodine as a catalyst under solvent-free conditions. This reaction is applicable to the chemoselective N-formylation of amino groups and -amino acid esters without epimerization.",
author = "Kim, {Joong Gon} and Jang, {Doo Ok}",
year = "2010",
month = "9",
day = "1",
doi = "10.1055/s-0030-1258518",
language = "English",
pages = "2093--2096",
journal = "Synlett",
issn = "0936-5214",
publisher = "Georg Thieme Verlag",
number = "14",

}

Kim, JG & Jang, DO 2010, 'Facile and highly efficient N-formylation of amines using a catalytic amount of iodine under solvent-free conditions', Synlett, no. 14, U04610ST, pp. 2093-2096. https://doi.org/10.1055/s-0030-1258518

Facile and highly efficient N-formylation of amines using a catalytic amount of iodine under solvent-free conditions. / Kim, Joong Gon; Jang, Doo Ok.

In: Synlett, No. 14, U04610ST, 01.09.2010, p. 2093-2096.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Facile and highly efficient N-formylation of amines using a catalytic amount of iodine under solvent-free conditions

AU - Kim, Joong Gon

AU - Jang, Doo Ok

PY - 2010/9/1

Y1 - 2010/9/1

N2 - We developed a simple, practical, and catalytic method for the N-formylation of a wide variety of amines in the presence of molecular iodine as a catalyst under solvent-free conditions. This reaction is applicable to the chemoselective N-formylation of amino groups and -amino acid esters without epimerization.

AB - We developed a simple, practical, and catalytic method for the N-formylation of a wide variety of amines in the presence of molecular iodine as a catalyst under solvent-free conditions. This reaction is applicable to the chemoselective N-formylation of amino groups and -amino acid esters without epimerization.

UR - http://www.scopus.com/inward/record.url?scp=77956014076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956014076&partnerID=8YFLogxK

U2 - 10.1055/s-0030-1258518

DO - 10.1055/s-0030-1258518

M3 - Article

AN - SCOPUS:77956014076

SP - 2093

EP - 2096

JO - Synlett

JF - Synlett

SN - 0936-5214

IS - 14

M1 - U04610ST

ER -

Kim JG, Jang DO. Facile and highly efficient N-formylation of amines using a catalytic amount of iodine under solvent-free conditions. Synlett. 2010 Sep 1;(14):2093-2096. U04610ST. https://doi.org/10.1055/s-0030-1258518

Access to Document