Successful implementation of a sequential Pd-catalyzed Sonogashira cross-coupling/iodine-promoted 5-exo-dig cyclization procedure with pyridines bearing a terminal alkyne moiety provided direct and straightforward access to a diverse array of 3-acylated indolizines under mild conditions.
Bibliographical noteFunding Information:
We thank Yonsei University for financial support.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry