Facile preparation of carbohydrate microarrays by site-specific, covalent immobilization of unmodified carbohydrates on hydrazide-coated glass slides

Myung Ryul Lee, Injae Shin

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

(Chemical Equation Presented) A new, simple and efficient immobilization method to attach mono-, di-, oligo-, and polysaccharides to hydrazide-coated glass slides was developed. Protein and cell-binding experiments show that the carbohydrate microarrays prepared by this method are applicable for the rapid analysis of protein-carbohydrate interactions and fast detection of pathogens.

Original languageEnglish
Pages (from-to)4269-4272
Number of pages4
JournalOrganic Letters
Volume7
Issue number19
DOIs
Publication statusPublished - 2005 Sep 15

Fingerprint

hydrazides
carbohydrates
Microarrays
immobilization
chutes
Immobilization
Glass
Carbohydrates
proteins
preparation
pathogens
glass
polysaccharides
Pathogens
Oligosaccharides
Protein Binding
Polysaccharides
Proteins
cells
Experiments

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

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Facile preparation of carbohydrate microarrays by site-specific, covalent immobilization of unmodified carbohydrates on hydrazide-coated glass slides. / Lee, Myung Ryul; Shin, Injae.

In: Organic Letters, Vol. 7, No. 19, 15.09.2005, p. 4269-4272.

Research output: Contribution to journalArticle

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