Facile synthetic route for surface-functionalized magnetic nanoparticles: Cell labeling and magnetic resonance imaging studies

Hyun Jung Chung, Haeshin Lee, Ki Hyun Bae, Yuhan Lee, Jongnam Park, Seung Woo Cho, Jin Young Hwang, Hyunwook Park, Robert Langer, Daniel Anderson, Tae Gwan Park

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Currently available methods to stably disperse iron oxide nanoparticles (IONPs) in aqueous solution need to be improved due to potential aggregation, reduction of superparamagnetism, and the use of toxic reagents. Herein, we present a facile strategy for aqueous transfer and dispersion of organic-synthesized IONPs using only polyethylene glycol (PEG), a biocompatible polymer. A library of PEG derivatives was screened, and it was determined that amine-functionalized six-armed PEG, 6(PEG-NH2), was the most effective dispersion agent. The 6(PEG-NH2)-modified IONPs (IONP-6PEG) were stable after extensive washing, exhibited high superparamagnetism, and could be used as a platform material for secondary surface functionalization with bioactive polymers. IONP-6PEG biofunctionalized with hyaluronic acid (IONP-6PEG-HA) was shown to specifically label mesenchymal stem cells and demonstrate MR contrast potential with high r2 relaxivity (442.7 s-1mM-1) compared to the commercially available Feridex (182.1 s-1mM-1).

Original languageEnglish
Pages (from-to)4329-4336
Number of pages8
JournalACS Nano
Volume5
Issue number6
DOIs
Publication statusPublished - 2011 Jun 28

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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    Chung, H. J., Lee, H., Bae, K. H., Lee, Y., Park, J., Cho, S. W., Hwang, J. Y., Park, H., Langer, R., Anderson, D., & Park, T. G. (2011). Facile synthetic route for surface-functionalized magnetic nanoparticles: Cell labeling and magnetic resonance imaging studies. ACS Nano, 5(6), 4329-4336. https://doi.org/10.1021/nn201198f