Facilitated self-assembly of novel dendron-based copolymers

Ryan M. Pearson, Jin Woo Bae, Suhair Sunoqrot, Sayam Uddin, Seungpyo Hong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Self-assembly of newly synthesized dendron-based amphiphilic copolymers with controlled hydrophilic-lipophilic balances has been investigated to evaluate their potential as a novel nanocarrier. The hydroxyl-terminated polyester dendron (G3) bearing a focal alkyne moiety was used to mediate the combination of poly(s-caprolactone) (PCL) with multiple polyethylene glycol (PEG) moieties. Four types of PCL-G3-mPEG with different block lengths were prepared and their structures were confirmed by 1H NMR, FT-IR, and GPC. Critical micelle concentration (CMC) values varied from 6.50 × 10 8 to 3.52 × 10 -7 M, which were lower than those reported for linear PCL-mPEG. TEM revealed that all PCL-G3-mPEG micelles were spherical with an average diameter of 20 nm. The drug release profile for each PCL-G3-mPEG was investigated by loading indomethacin (IMC), as a model drug, within the micelles. IMC was released in a controlled manner over 72 hours. Synthesized copolymers used in this study were also found to be non-cytotoxic at concentrations up to 100 M. The low CMC, along with the controlled morphology, release profile and biocompatibility, all demonstrate the potential of the dendron-based micelles as a novel nanocarrier.

Original languageEnglish
Title of host publication33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Pages8334-8336
Number of pages3
DOIs
Publication statusPublished - 2011 Dec 26
Event33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States
Duration: 2011 Aug 302011 Sep 3

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
CountryUnited States
CityBoston, MA
Period11/8/3011/9/3

Fingerprint

Micelles
Self assembly
Copolymers
Critical micelle concentration
Bearings (structural)
Indomethacin
Biocompatibility
Polyethylene glycols
Polyesters
Nuclear magnetic resonance
Alkynes
Transmission electron microscopy
Hydroxyl Radical
dendron
methoxy poly(ethylene glycol-co-epsilon-caprolactone)
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Pearson, R. M., Bae, J. W., Sunoqrot, S., Uddin, S., & Hong, S. (2011). Facilitated self-assembly of novel dendron-based copolymers. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 (pp. 8334-8336). [6092055] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6092055
Pearson, Ryan M. ; Bae, Jin Woo ; Sunoqrot, Suhair ; Uddin, Sayam ; Hong, Seungpyo. / Facilitated self-assembly of novel dendron-based copolymers. 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. pp. 8334-8336 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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Pearson, RM, Bae, JW, Sunoqrot, S, Uddin, S & Hong, S 2011, Facilitated self-assembly of novel dendron-based copolymers. in 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011., 6092055, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 8334-8336, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011, Boston, MA, United States, 11/8/30. https://doi.org/10.1109/IEMBS.2011.6092055

Facilitated self-assembly of novel dendron-based copolymers. / Pearson, Ryan M.; Bae, Jin Woo; Sunoqrot, Suhair; Uddin, Sayam; Hong, Seungpyo.

33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. p. 8334-8336 6092055 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Pearson RM, Bae JW, Sunoqrot S, Uddin S, Hong S. Facilitated self-assembly of novel dendron-based copolymers. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. p. 8334-8336. 6092055. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6092055