Factor analysis-derived cognitive profile predicting early dementia conversion in PD

Seok Jong Chung, Hye Sun Lee, Hang Rai Kim, Han Soo Yoo, Yang Hyun Lee, Jin Ho Jung, Kyoung Won Baik, Byoung Seok Ye, Young H. Sohn, Phil Hyu Lee

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


OBJECTIVES: To investigate which baseline neuropsychological profile predicts the risk of developing dementia in early-stage Parkinson disease (PD). METHODS: We retrospectively reviewed detailed medical records of 350 drug-naive patients with early-stage PD (follow-up >3 years) who underwent a detailed neuropsychological test at initial assessment. Factor analysis was conducted to determine cognitive profiles that yielded 4 cognitive function factors: factor 1, visual memory/visuospatial; factor 2, verbal memory; factor 3, frontal/executive; and factor 4, attention/working memory/language. Subsequently, we assessed the effect of these cognitive function factors on the risk for dementia conversion. We also constructed a nomogram to calculate the risk for developing dementia over a 5-year follow-up period based on these cognitive profiles. RESULTS: Cox regression analysis demonstrated that a higher composite score of factor 1 (hazard ratio [HR] 0.558, 95% confidence interval [CI] 0.427-0.730), factor 2 (HR 0.768, 95% CI 0.596-0.991), and factor 3 (HR 0.425, 95% CI 0.305-0.593) was associated with a lower risk for dementia conversion, while factor 3 had the most predictive power. The nomogram had a fair ability (Heagerty integrated area under the curve 0.763) to estimate the risk for dementia conversion within 5 years. The composite scores of factor 3 contributed more to the occurrence of dementia in PD than those of the other cognitive function factors. CONCLUSIONS: These findings suggest that these factor analysis-derived cognitive profiles can be used to predict dementia conversion in early-stage PD. In addition, frontal/executive dysfunction contributes most to the occurrence of dementia in PD.

Original languageEnglish
Pages (from-to)e1650-e1659
Issue number12
Publication statusPublished - 2020 Sep 22

Bibliographical note

Publisher Copyright:
© 2020 American Academy of Neurology.

All Science Journal Classification (ASJC) codes

  • Clinical Neurology


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