Factors affecting medication adherence and anticoagulation control in Korean patients taking warfarin

Jae Hee Kim, Gwangsuk Kim, Eun Jung Kim, Sungha Park, Namsik Chung, Sang Hui Chu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background and Research Objective: Poor adherence in patients taking warfarin may be one of the most common barriers to obtain favorable anticoagulation outcomes. This study was conducted to identify factors affecting medication adherence and their relationships with anticoagulation control in Korean patients taking warfarin. Subjects and Methods: In a cross-sectional survey, 204 patients taking warfarin who had visited an outpatient clinic of a cardiovascular center located in Seoul, Korea, were included as research subjects. Medication adherence, knowledge about warfarin, self-efficacy, and patient understanding of the international normalized ratio (INR) were investigated. Participants' medical records were also reviewed to identify clinical characteristics including comorbid conditions, warfarin regimen, and INR. Results and Conclusions: When medication adherence was defined as taking warfarin according to medical advice (frequency, dosage, time, and precautions), 56 (27.5%) of 204 respondents were adherent. The adherent group had a greater understanding about warfarin than the nonadherent group as measured by 10 survey items (7.20 ± 1.70 vs 6.56 ± 1.84; P < .05) and had significantly higher self-efficacy (P < .000). However, medication adherence was not associated with good anticoagulation level as measured by INR. The results show that knowledge about warfarin and self-efficacy exert significant influence on medication adherence, and yet medication adherence did not predict therapeutic anticoagulation control. Further studies are needed to identify factors predicting favorable anticoagulation control in patients taking warfarin.

Original languageEnglish
Pages (from-to)466-474
Number of pages9
JournalJournal of Cardiovascular Nursing
Volume26
Issue number6
DOIs
Publication statusPublished - 2011 Nov 1

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Medication Adherence
Warfarin
International Normalized Ratio
Self Efficacy
Research Subjects
Patient Compliance
Korea
Ambulatory Care Facilities
Medical Records
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

Cite this

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abstract = "Background and Research Objective: Poor adherence in patients taking warfarin may be one of the most common barriers to obtain favorable anticoagulation outcomes. This study was conducted to identify factors affecting medication adherence and their relationships with anticoagulation control in Korean patients taking warfarin. Subjects and Methods: In a cross-sectional survey, 204 patients taking warfarin who had visited an outpatient clinic of a cardiovascular center located in Seoul, Korea, were included as research subjects. Medication adherence, knowledge about warfarin, self-efficacy, and patient understanding of the international normalized ratio (INR) were investigated. Participants' medical records were also reviewed to identify clinical characteristics including comorbid conditions, warfarin regimen, and INR. Results and Conclusions: When medication adherence was defined as taking warfarin according to medical advice (frequency, dosage, time, and precautions), 56 (27.5{\%}) of 204 respondents were adherent. The adherent group had a greater understanding about warfarin than the nonadherent group as measured by 10 survey items (7.20 ± 1.70 vs 6.56 ± 1.84; P < .05) and had significantly higher self-efficacy (P < .000). However, medication adherence was not associated with good anticoagulation level as measured by INR. The results show that knowledge about warfarin and self-efficacy exert significant influence on medication adherence, and yet medication adherence did not predict therapeutic anticoagulation control. Further studies are needed to identify factors predicting favorable anticoagulation control in patients taking warfarin.",
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Factors affecting medication adherence and anticoagulation control in Korean patients taking warfarin. / Kim, Jae Hee; Kim, Gwangsuk; Kim, Eun Jung; Park, Sungha; Chung, Namsik; Chu, Sang Hui.

In: Journal of Cardiovascular Nursing, Vol. 26, No. 6, 01.11.2011, p. 466-474.

Research output: Contribution to journalArticle

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