Factors affecting pouch-related outcomes after restorative proctocolectomy

Gyoung Tae Noh, Jeonghee Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim

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2 Citations (Scopus)

Abstract

Purposes: Restorative proctocolectomy (RPC) with ileal pouch anal anastomosis (IPAA) is the procedure of choice for patients with familial adenomatous polyposis (FAP) and ulcerative colitis (UC) despite morbidities that can lead to pouch failure. We aimed to identify factors associated with pouch-related morbidities. Methods: A retrospective analysis of patients who underwent RPC with IPAA was performed. To investigate the factors associated with pouch-related morbidities, patients’ preoperative demographic and clinical factors, and intraoperative factors were included in the analysis. Results: A total of 49 patients with UC, FAP, and colorectal cancer were included. Twenty patients (40.8%) experienced leakage-related, functional, and/or pouchitis-related morbidities. Patients with American Society of Anesthesiologists (ASA) grade 2 or 3 had a higher risk of functional morbidity than those with grade 1. Intraoperative blood loss exceeding 300.0 mL was associated with an increased risk of pouchitis-related morbidity. Conclusions: Our study demonstrated associations of higher ASA grade and increased intraoperative blood loss with poor functional outcomes and pouchitis, respectively.

Original languageEnglish
Article numbere0186596
JournalPloS one
Volume12
Issue number10
DOIs
Publication statusPublished - 2017 Oct

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Noh, G. T., Han, J., Cho, M. S., Hur, H., Min, B. S., Lee, K. Y., & Kim, N. K. (2017). Factors affecting pouch-related outcomes after restorative proctocolectomy. PloS one, 12(10), [e0186596]. https://doi.org/10.1371/journal.pone.0186596