While focused ultrasound (FUS) is non-invasive, the ultrasound energy is attenuated by the skull which results in differences in energy efficiency among patients. In this study, we investigated the effect of skull variables on the energy efficiency of FUS. The thickness and density of the skull and proportion of the trabecular bone were selected as factors that could affect ultrasound energy transmittance. Sixteen 3D-printed skull models were designed and fabricated to reflect the three factors. The energy of each phantom was measured using an ultrasonic sound field energy measurement system. The thickness and proportion of trabecular bone affected the attenuation of transmitted energy. There was no difference in the density of the trabecular bone. In clinical data, the trabecular bone ratio showed a significantly greater correlation with dose/delivered energy than that of thickness and the skull density ratio. Currently, for clinical non-thermal FUS, the data are not sufficient, but we believe that the results of this study will be helpful in selecting patients and appropriate parameters for FUS treatment.
|Journal||Frontiers in Bioengineering and Biotechnology|
|Publication status||Published - 2021 Dec 10|
Bibliographical noteFunding Information:
This research was funded by the National Research Foundation of Korea (NRF), supported by the Ministry of
This research was funded by the National Research Foundation of Korea (NRF), supported by the Ministry of Science, Information and Communication Technology and Future Planning (NRF 2020R1A2C2008480 and NRF2016R1D1A3B03932649) and Korea Medical Device Development Fund (KMDF_PR_20200901_0103).
Copyright © 2021 Kong, Park, Shin, Baek, Park, Na, Chang and Chang.
All Science Journal Classification (ASJC) codes
- Biomedical Engineering