Factors associated with HIV-1 proviral DNA loads in patients with undetectable plasma RNA load

Jun Yong Choi, Young Goo Song, Young Hwa Kim, Chang Oh Kim, Myung Soo Kim, Bum Sik Chin, Sang Hoon Han, Suk Hoon Choi, Han Sung Lee, Su Jin Jeong, Heekyoung Choi, June Myung Kim

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2 Citations (Scopus)

Abstract

To evaluate factors associated with human immunodeficiency virus type 1 (HIV-1) proviral DNA load, we conducted a cross-sectional study of 36 chronically HIV-1-infected individuals with undetectable plasma viral RNA. We used real-time polymerase chain reaction to determine the number of HIV-1 proviral DNA copies per 106 peripheral blood mononuclear cells. The mean level of plasma viral RNA when the CD4+ T cell count was above 500 cells/μL without highly active antiretroviral therapy (HAART) was significantly associated with proviral DNA load at the time of undetectable plasma HIV RNA with HAART. Strategies to reduce the level of plasma viral RNA when patients' CD4+ T cell counts are above 500 cells/μL without HAART could help reduce HIV-1 proviral DNA load.

Original languageEnglish
Pages (from-to)152-154
Number of pages3
JournalJournal of Korean medical science
Volume24
Issue number1
DOIs
Publication statusPublished - 2009 Feb

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Choi, J. Y., Song, Y. G., Kim, Y. H., Kim, C. O., Kim, M. S., Chin, B. S., Han, S. H., Choi, S. H., Lee, H. S., Jeong, S. J., Choi, H., & Kim, J. M. (2009). Factors associated with HIV-1 proviral DNA loads in patients with undetectable plasma RNA load. Journal of Korean medical science, 24(1), 152-154. https://doi.org/10.3346/jkms.2009.24.1.152