Factors associated with natural seroclearance of hepatitis B surface antigen and prognosis after seroclearance

A prospective follow-up study

Hwan Kim Jeong, Hyoek Lee Joon, Jong Park Sang, Hee Bae Mun, Hyang Kim Ji, doyoung kim, Kyu Kim Jong, Seok Choi Moon, Cheol Koh Kwang, Woon Paik Seung, Chul Yoo Byung

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background/Aims: Although the natural seroclearance rate of Hepatitis B surface antigen (HBsAg) is reported to be 0.4-2% in western countries, this is not well known in Korea. This study aimed to elucidate the rate of natural HbsAg seroclearance, factors associated with seroclearance and prognosis after seroclearance. Methodology: In 1999, 250 chronic HBsAg carriers without any history of antiviral treatment and without any evidence of liver cirrhosis or hepatocellular carcinoma were selected. Follow-up HBsAg/anti-HBs tests were performed annually till 2004. During a mean follow-up period of 48 months, 24 patients were lost and 11 received antiviral treatment. Finally, 215 patients completed the study. Results: HBsAg seroclearance was observed in 11 patients (6 males, 5 females). One-year seroclearance rate was 1.4%. All patients who achieved seroclearance were HBeAg (-)/HBV DNA (-) at the time of enrollment. Additionally, old age and normal serum alanine aminotransferase (ALT) level were the factors associated with seroclearance (p<0.05, respectively). During the follow-up period, only mild transient elevations of ALT were observed in 4 patients and no serious complications were observed. Conclusions: Natural seroclearance occurred exclusively in patients who were HBeAg (-)/HBV-DNA (-), and annual rate of natural HBsAg seroclearance was 1.4%. No significant complications were observed after seroclearance.

Original languageEnglish
Pages (from-to)578-581
Number of pages4
JournalHepato-Gastroenterology
Volume55
Issue number82-83
Publication statusPublished - 2008 Mar 1

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Hepatitis B Surface Antigens
Hepatitis B e Antigens
Alanine Transaminase
Antiviral Agents
DNA
Chronic Hepatitis B
Korea
Liver Cirrhosis
Hepatocellular Carcinoma
Therapeutics
Serum

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Jeong, Hwan Kim ; Joon, Hyoek Lee ; Sang, Jong Park ; Mun, Hee Bae ; Ji, Hyang Kim ; kim, doyoung ; Jong, Kyu Kim ; Moon, Seok Choi ; Kwang, Cheol Koh ; Seung, Woon Paik ; Byung, Chul Yoo. / Factors associated with natural seroclearance of hepatitis B surface antigen and prognosis after seroclearance : A prospective follow-up study. In: Hepato-Gastroenterology. 2008 ; Vol. 55, No. 82-83. pp. 578-581.
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title = "Factors associated with natural seroclearance of hepatitis B surface antigen and prognosis after seroclearance: A prospective follow-up study",
abstract = "Background/Aims: Although the natural seroclearance rate of Hepatitis B surface antigen (HBsAg) is reported to be 0.4-2{\%} in western countries, this is not well known in Korea. This study aimed to elucidate the rate of natural HbsAg seroclearance, factors associated with seroclearance and prognosis after seroclearance. Methodology: In 1999, 250 chronic HBsAg carriers without any history of antiviral treatment and without any evidence of liver cirrhosis or hepatocellular carcinoma were selected. Follow-up HBsAg/anti-HBs tests were performed annually till 2004. During a mean follow-up period of 48 months, 24 patients were lost and 11 received antiviral treatment. Finally, 215 patients completed the study. Results: HBsAg seroclearance was observed in 11 patients (6 males, 5 females). One-year seroclearance rate was 1.4{\%}. All patients who achieved seroclearance were HBeAg (-)/HBV DNA (-) at the time of enrollment. Additionally, old age and normal serum alanine aminotransferase (ALT) level were the factors associated with seroclearance (p<0.05, respectively). During the follow-up period, only mild transient elevations of ALT were observed in 4 patients and no serious complications were observed. Conclusions: Natural seroclearance occurred exclusively in patients who were HBeAg (-)/HBV-DNA (-), and annual rate of natural HBsAg seroclearance was 1.4{\%}. No significant complications were observed after seroclearance.",
author = "Jeong, {Hwan Kim} and Joon, {Hyoek Lee} and Sang, {Jong Park} and Mun, {Hee Bae} and Ji, {Hyang Kim} and doyoung kim and Jong, {Kyu Kim} and Moon, {Seok Choi} and Kwang, {Cheol Koh} and Seung, {Woon Paik} and Byung, {Chul Yoo}",
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Jeong, HK, Joon, HL, Sang, JP, Mun, HB, Ji, HK, kim, D, Jong, KK, Moon, SC, Kwang, CK, Seung, WP & Byung, CY 2008, 'Factors associated with natural seroclearance of hepatitis B surface antigen and prognosis after seroclearance: A prospective follow-up study', Hepato-Gastroenterology, vol. 55, no. 82-83, pp. 578-581.

Factors associated with natural seroclearance of hepatitis B surface antigen and prognosis after seroclearance : A prospective follow-up study. / Jeong, Hwan Kim; Joon, Hyoek Lee; Sang, Jong Park; Mun, Hee Bae; Ji, Hyang Kim; kim, doyoung; Jong, Kyu Kim; Moon, Seok Choi; Kwang, Cheol Koh; Seung, Woon Paik; Byung, Chul Yoo.

In: Hepato-Gastroenterology, Vol. 55, No. 82-83, 01.03.2008, p. 578-581.

Research output: Contribution to journalArticle

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T1 - Factors associated with natural seroclearance of hepatitis B surface antigen and prognosis after seroclearance

T2 - A prospective follow-up study

AU - Jeong, Hwan Kim

AU - Joon, Hyoek Lee

AU - Sang, Jong Park

AU - Mun, Hee Bae

AU - Ji, Hyang Kim

AU - kim, doyoung

AU - Jong, Kyu Kim

AU - Moon, Seok Choi

AU - Kwang, Cheol Koh

AU - Seung, Woon Paik

AU - Byung, Chul Yoo

PY - 2008/3/1

Y1 - 2008/3/1

N2 - Background/Aims: Although the natural seroclearance rate of Hepatitis B surface antigen (HBsAg) is reported to be 0.4-2% in western countries, this is not well known in Korea. This study aimed to elucidate the rate of natural HbsAg seroclearance, factors associated with seroclearance and prognosis after seroclearance. Methodology: In 1999, 250 chronic HBsAg carriers without any history of antiviral treatment and without any evidence of liver cirrhosis or hepatocellular carcinoma were selected. Follow-up HBsAg/anti-HBs tests were performed annually till 2004. During a mean follow-up period of 48 months, 24 patients were lost and 11 received antiviral treatment. Finally, 215 patients completed the study. Results: HBsAg seroclearance was observed in 11 patients (6 males, 5 females). One-year seroclearance rate was 1.4%. All patients who achieved seroclearance were HBeAg (-)/HBV DNA (-) at the time of enrollment. Additionally, old age and normal serum alanine aminotransferase (ALT) level were the factors associated with seroclearance (p<0.05, respectively). During the follow-up period, only mild transient elevations of ALT were observed in 4 patients and no serious complications were observed. Conclusions: Natural seroclearance occurred exclusively in patients who were HBeAg (-)/HBV-DNA (-), and annual rate of natural HBsAg seroclearance was 1.4%. No significant complications were observed after seroclearance.

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