Factors associated with natural seroclearance of hepatitis B surface antigen and prognosis after seroclearance: A prospective follow-up study

Hwan Kim Jeong, Hyoek Lee Joon, Jong Park Sang, Hee Bae Mun, Hyang Kim Ji, Young Kim Do, Kyu Kim Jong, Seok Choi Moon, Cheol Koh Kwang, Woon Paik Seung, Chul Yoo Byung

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Abstract

Background/Aims: Although the natural seroclearance rate of Hepatitis B surface antigen (HBsAg) is reported to be 0.4-2% in western countries, this is not well known in Korea. This study aimed to elucidate the rate of natural HbsAg seroclearance, factors associated with seroclearance and prognosis after seroclearance. Methodology: In 1999, 250 chronic HBsAg carriers without any history of antiviral treatment and without any evidence of liver cirrhosis or hepatocellular carcinoma were selected. Follow-up HBsAg/anti-HBs tests were performed annually till 2004. During a mean follow-up period of 48 months, 24 patients were lost and 11 received antiviral treatment. Finally, 215 patients completed the study. Results: HBsAg seroclearance was observed in 11 patients (6 males, 5 females). One-year seroclearance rate was 1.4%. All patients who achieved seroclearance were HBeAg (-)/HBV DNA (-) at the time of enrollment. Additionally, old age and normal serum alanine aminotransferase (ALT) level were the factors associated with seroclearance (p<0.05, respectively). During the follow-up period, only mild transient elevations of ALT were observed in 4 patients and no serious complications were observed. Conclusions: Natural seroclearance occurred exclusively in patients who were HBeAg (-)/HBV-DNA (-), and annual rate of natural HBsAg seroclearance was 1.4%. No significant complications were observed after seroclearance.

Original languageEnglish
Pages (from-to)578-581
Number of pages4
JournalHepato-gastroenterology
Volume55
Issue number82-83
Publication statusPublished - 2008 Mar 1

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All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Jeong, H. K., Joon, H. L., Sang, J. P., Mun, H. B., Ji, H. K., Do, Y. K., Jong, K. K., Moon, S. C., Kwang, C. K., Seung, W. P., & Byung, C. Y. (2008). Factors associated with natural seroclearance of hepatitis B surface antigen and prognosis after seroclearance: A prospective follow-up study. Hepato-gastroenterology, 55(82-83), 578-581.