Abstract
Background: To evaluate factors associated with the lack of adjuvant chemotherapy after curative surgery in patients with stage II and III colon cancer based on national population-based data. Patients and Methods: A total of 8,412 patients diagnosed with stage II or III disease who underwent curative resection were included. Results: Adjuvant chemotherapy was not administered in 3,057 cases (36.34%). Factors associated with the lack of chemotherapy were older age [hazard ratio (HR)=1.50 in patients 65-74 years and 5.23 in patients ≥75 years of age], female sex (HR=1.15), tumor-node-metastasis (TNM) stage II (HR=4.28), emergency surgery (HR=1.45), American Society of Anesthesiologists (ASA) score of 3 or higher (HR=1.62), fewer than 12 lymph nodes examined (HR=1.19), a greater quantity of transfusion (HR=1.08), and hospital type (tertiary referral center) (HR=1.62). Conclusion: Patientrelated (older age, female sex, and ASA score of 3 or higher) and treatment-related factors (TNM stage II, emergency surgery, fewer than 12 lymph nodes examined, a greater quantity of transfusion, and hospital type) influenced the lack of adjuvant chemotherapy. Given that the use of adjuvant chemotherapy improves overall survival, physicians should make an effort to increase the proportion of patients receiving chemotherapy after surgery.
| Original language | English |
|---|---|
| Pages (from-to) | 915-922 |
| Number of pages | 8 |
| Journal | Anticancer Research |
| Volume | 37 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2017 Jan 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
}
Factors associated with the lack of adjuvant chemotherapy following curative surgery for stage II and III colon cancer : A Korean national cohort study. / Ha, Gye Sung; Kim, Young Wan; Choi, Eun Hee; Kim, Ik Yong.
In: Anticancer Research, Vol. 37, No. 2, 01.01.2017, p. 915-922.Research output: Contribution to journal › Article
TY - JOUR
T1 - Factors associated with the lack of adjuvant chemotherapy following curative surgery for stage II and III colon cancer
T2 - A Korean national cohort study
AU - Ha, Gye Sung
AU - Kim, Young Wan
AU - Choi, Eun Hee
AU - Kim, Ik Yong
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Background: To evaluate factors associated with the lack of adjuvant chemotherapy after curative surgery in patients with stage II and III colon cancer based on national population-based data. Patients and Methods: A total of 8,412 patients diagnosed with stage II or III disease who underwent curative resection were included. Results: Adjuvant chemotherapy was not administered in 3,057 cases (36.34%). Factors associated with the lack of chemotherapy were older age [hazard ratio (HR)=1.50 in patients 65-74 years and 5.23 in patients ≥75 years of age], female sex (HR=1.15), tumor-node-metastasis (TNM) stage II (HR=4.28), emergency surgery (HR=1.45), American Society of Anesthesiologists (ASA) score of 3 or higher (HR=1.62), fewer than 12 lymph nodes examined (HR=1.19), a greater quantity of transfusion (HR=1.08), and hospital type (tertiary referral center) (HR=1.62). Conclusion: Patientrelated (older age, female sex, and ASA score of 3 or higher) and treatment-related factors (TNM stage II, emergency surgery, fewer than 12 lymph nodes examined, a greater quantity of transfusion, and hospital type) influenced the lack of adjuvant chemotherapy. Given that the use of adjuvant chemotherapy improves overall survival, physicians should make an effort to increase the proportion of patients receiving chemotherapy after surgery.
AB - Background: To evaluate factors associated with the lack of adjuvant chemotherapy after curative surgery in patients with stage II and III colon cancer based on national population-based data. Patients and Methods: A total of 8,412 patients diagnosed with stage II or III disease who underwent curative resection were included. Results: Adjuvant chemotherapy was not administered in 3,057 cases (36.34%). Factors associated with the lack of chemotherapy were older age [hazard ratio (HR)=1.50 in patients 65-74 years and 5.23 in patients ≥75 years of age], female sex (HR=1.15), tumor-node-metastasis (TNM) stage II (HR=4.28), emergency surgery (HR=1.45), American Society of Anesthesiologists (ASA) score of 3 or higher (HR=1.62), fewer than 12 lymph nodes examined (HR=1.19), a greater quantity of transfusion (HR=1.08), and hospital type (tertiary referral center) (HR=1.62). Conclusion: Patientrelated (older age, female sex, and ASA score of 3 or higher) and treatment-related factors (TNM stage II, emergency surgery, fewer than 12 lymph nodes examined, a greater quantity of transfusion, and hospital type) influenced the lack of adjuvant chemotherapy. Given that the use of adjuvant chemotherapy improves overall survival, physicians should make an effort to increase the proportion of patients receiving chemotherapy after surgery.
UR - http://www.scopus.com/inward/record.url?scp=85013641216&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85013641216&partnerID=8YFLogxK
U2 - 10.21873/anticanres.11399
DO - 10.21873/anticanres.11399
M3 - Article
C2 - 28179352
AN - SCOPUS:85013641216
VL - 37
SP - 915
EP - 922
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 2
ER -