Factors Determining Aortic Valve Dysfunction in Korean Subjects With a Bicuspid Aortic Valve

Soo Youn Lee, ChiYoung Shim, Darae Kim, Iksung Cho, Geu Ru Hong, Jong Won Ha, Namsik Chung

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3 Citations (Scopus)

Abstract

Bicuspid aortic valve (BAV) disease has a male predominance of approximately 3:1 and shows diverse presentations about aortic valve dysfunction. This study aimed to find independent determinants for significant aortic stenosis (AS) or significant aortic regurgitation (AR) in adults with BAV. We retrospectively investigated the medical records of 1,073 subjects (773 men, mean age 55 ± 14 years) who were first diagnosed with BAV disease by transthoracic echocardiography. We excluded 52 subjects with both significant AS and significant AR. Of the remaining 1,021 subjects, 418 (41%) presented with significant AS, 249 (24%) showed significant AR, and the rest of the subjects were grouped into a normal functioning BAV (n = 354, 35%). BAV morphology was classified into the following 4 types according to position and pattern of raphe and cusps: (1) fusion of the right and left coronary cusps (type 1), (2) fusion of the right and noncoronary cusps (type 2), (3) fusion of the left and noncoronary (type 3), and (4) no raphe (type 0). Patients with significant AS were older, more likely to be women than men, and had a higher prevalence of type 0 BAV. Patients with significant AR were younger and were more likely to be men. In multivariate logistic regression analysis, women, older age, and type 0 or type 3 BAV were associated with significant AS. In contrast, men, hypertension, and chronic kidney disease were correlated with significant AR. Significant valve dysfunction in adults with first diagnosed BAV was closely associated with age, gender, and BAV morphology.

Original languageEnglish
Pages (from-to)2049-2055
Number of pages7
JournalAmerican Journal of Cardiology
Volume119
Issue number12
DOIs
Publication statusPublished - 2017 Jun 15

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Aortic Valve
Aortic Valve Insufficiency
Aortic Valve Stenosis
Aortic Diseases
Bicuspid Aortic Valve
Chronic Renal Insufficiency
Medical Records
Echocardiography
Logistic Models
Regression Analysis
Hypertension

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Lee, Soo Youn ; Shim, ChiYoung ; Kim, Darae ; Cho, Iksung ; Hong, Geu Ru ; Ha, Jong Won ; Chung, Namsik. / Factors Determining Aortic Valve Dysfunction in Korean Subjects With a Bicuspid Aortic Valve. In: American Journal of Cardiology. 2017 ; Vol. 119, No. 12. pp. 2049-2055.
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abstract = "Bicuspid aortic valve (BAV) disease has a male predominance of approximately 3:1 and shows diverse presentations about aortic valve dysfunction. This study aimed to find independent determinants for significant aortic stenosis (AS) or significant aortic regurgitation (AR) in adults with BAV. We retrospectively investigated the medical records of 1,073 subjects (773 men, mean age 55 ± 14 years) who were first diagnosed with BAV disease by transthoracic echocardiography. We excluded 52 subjects with both significant AS and significant AR. Of the remaining 1,021 subjects, 418 (41{\%}) presented with significant AS, 249 (24{\%}) showed significant AR, and the rest of the subjects were grouped into a normal functioning BAV (n = 354, 35{\%}). BAV morphology was classified into the following 4 types according to position and pattern of raphe and cusps: (1) fusion of the right and left coronary cusps (type 1), (2) fusion of the right and noncoronary cusps (type 2), (3) fusion of the left and noncoronary (type 3), and (4) no raphe (type 0). Patients with significant AS were older, more likely to be women than men, and had a higher prevalence of type 0 BAV. Patients with significant AR were younger and were more likely to be men. In multivariate logistic regression analysis, women, older age, and type 0 or type 3 BAV were associated with significant AS. In contrast, men, hypertension, and chronic kidney disease were correlated with significant AR. Significant valve dysfunction in adults with first diagnosed BAV was closely associated with age, gender, and BAV morphology.",
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Factors Determining Aortic Valve Dysfunction in Korean Subjects With a Bicuspid Aortic Valve. / Lee, Soo Youn; Shim, ChiYoung; Kim, Darae; Cho, Iksung; Hong, Geu Ru; Ha, Jong Won; Chung, Namsik.

In: American Journal of Cardiology, Vol. 119, No. 12, 15.06.2017, p. 2049-2055.

Research output: Contribution to journalArticle

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