Factors Determining Early Left Atrial Reverse Remodeling After Mitral Valve Surgery

Deok Kyu Cho, Jong Won Ha, Byung Chul Chang, Se Hwa Lee, Se Jung Yoon, Chi Young Shim, Jung Rae Cho, Jung Sun Kim, Eui Young Choi, Se Joong Rim, Namsik Chung

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


This study aimed to investigate the factors determining early left atrial (LA) reverse remodeling after mitral valve (MV) surgery. The left atrium is frequently dilated in patients with mitral stenosis (MS) or mitral regurgitation (MR). MV surgery usually results in LA volume reduction. However, the factors associated with LA reverse remodeling after MV surgery are not clearly defined. One hundred thirty-eight patients (51 men, 87 women; mean age, 53 years) underwent transthoracic echocardiography before and after MV surgery. Maximal LA volume was measured using the prolate ellipsoid model. The percentage of LA volume change was calculated. The patients were grouped according to age (<50 vs ≥50 years), predominant lesion (pure MR vs some degree of MS), type of surgery (MV repair vs MV replacement), and preoperative rhythm (sinus rhythm vs atrial fibrillation). LA volume decreased from 147 ± 93 to 103 ± 43 ml (p <0.001) after surgery. LA reverse remodeling was more prominent in patients who were <50 years old (percentage of LA volume change -31.2 ± 17.4 vs -18.4 ± 19.2, p <0.001), had pure MR (percentage of LA volume change -30.4 ± 18.6 vs -17.3 ± 18.2, p <0.001), and had a preoperative sinus rhythm (percentage of LA volume change -28.5 ± 17.7 vs -20.5 ± 20.0, p = 0.019). In conclusion, on stepwise multiple regression analysis, preoperative LA volume, predominant lesion, age, and cardiac rhythm were significant predictors of LA reverse remodeling. A larger preoperative LA volume, MR rather than MS, younger age at the time of surgery, and sinus rhythm were important predictors of LA reverse remodeling after MV surgery.

Original languageEnglish
Pages (from-to)374-377
Number of pages4
JournalAmerican Journal of Cardiology
Issue number3
Publication statusPublished - 2008 Feb 1

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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