Factors for Enhancement of Intracranial Atherosclerosis in High Resolution Vessel Wall MRI in Ischemic Stroke Patients

Na Eun Woo, Han Kyu Na, Ji Hoe Heo, Hyo Suk Nam, Jin Kyo Choi, Sung Soo Ahn, Hyun Seok Choi, Seung Koo Lee, Hye Sun Lee, Jihoon Cha, Young Dae Kim

Research output: Contribution to journalArticle

Abstract

Introduction: High resolution vessel wall MRI (VW-MRI) has enabled to characterize intracranial atherosclerosis (ICAS). We studied to identify the factors for enhancement of ICAS in VW-MRI in patients with acute ischemic stroke. Methods: Consecutive patients with acute ischemic stroke or TIA who underwent VW-MRI between January 2017 and December 2017 were included. Enhancement on VW-MRI was defined as an increase in intensity on contrast-enhanced T1-weighted sequence. We compared the clinical and the radiologic findings between patients with wall enhancement and those without wall enhancement. Results: Of the 48 patients with ICAS, 28 patients revealed enhancement on VW-MRI. Patients with enhancement were more likely to have severe stenotic lesions and higher levels of total cholesterol, triglycerides, low-density cholesterol, Apo (b), and Apo (b)/Apo (a) lipoprotein ratio (p < 0.05). Multivariable analysis demonstrated that total cholesterol (OR: 5.378, 95% CI, 1.779–16.263), triglycerides (OR: 3.362, 95% CI, 1.008–11.209), low density lipoprotein cholesterol (OR: 4.226, 95% CI, 1.264–14.126), Apo (b) lipoprotein (OR: 3639.641, 95% CI, 17.854–741954.943) levels, and Apo (b)/Apo (a) lipoprotein ratio (OR, 65.514; 95% CI, 1.131–3680.239) were independently associated with enhancement of ICAS. High-density lipoprotein cholesterol and Apo (a) lipoprotein levels were not significantly different between the patients with wall enhancement and those without wall enhancement. Conclusions: The presence and severity of enhancement of ICAS was significantly associated with dyslipidemic conditions. These results suggest that strict lipid modification should be achieved for the management of ICAS.

Original languageEnglish
Article number580
JournalFrontiers in Neurology
Volume11
DOIs
Publication statusPublished - 2020 Jun 26

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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    Woo, N. E., Na, H. K., Heo, J. H., Nam, H. S., Choi, J. K., Ahn, S. S., Choi, H. S., Lee, S. K., Lee, H. S., Cha, J., & Kim, Y. D. (2020). Factors for Enhancement of Intracranial Atherosclerosis in High Resolution Vessel Wall MRI in Ischemic Stroke Patients. Frontiers in Neurology, 11, [580]. https://doi.org/10.3389/fneur.2020.00580