Factors in the breast core needle biopsies of atypical ductal hyperplasia that can predict carcinoma in the subsequent surgical excision specimens

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Purpose: Our purpose was to identify the factors in a breast core needle biopsy (CNB) of atypical ductal hyperplasia (ADH) that are predictive for carcinoma in the subsequent excision specimens. Methods: We performed a retrospective pathologic review of 50 cases that were diagnosed as ADH via the CNB and that had the corresponding excision specimens. Results: The size of the largest ADH foci in the CNBs was 0.8 ±0.6 mm (mean±SD) for benign proliferative disease (BPD, n=12), 1.0 ±0.5 mm (mean±SD) for ADH (n= 9) and 1.3±0.8 mm (mean±SD) for malignant lesions (n= 29) in excision specimens (p=0.105). Among the 30 cases showing stromal alterations around the ducts with ADH in the CNBs, 9 cases (30.0%) were BPD or ADH and 21 cases (70.0%) were malignant lesions in the excision specimens (p=0.004). Conclusion: As the stromal alterations around the ADH were noted in the CNB, there was an increased likelihood that more advanced lesions would be identified in the surgical excision specimens.

Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalJournal of Breast Cancer
Issue number2
Publication statusPublished - 2010 Jun 1


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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