Factors influencing the diagnostic accuracy of acoustic radiation force impulse elastography in patients with chronic hepatitis B

Mi Sung Park, Sun Wook Kim, Ki Tae Yoon, Seung Up Kim, Soo Young Park, Won Young Tak, Young Oh Kweon, Mong Cho, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang Hyub Han

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background/Aims: To determine factors predictive of discordance in staging liver fibrosis using liver biopsy (LB) and acoustic radiation force impulse (ARFI) elastography in patients with chronic hepatitis B (CHB). Methods: Consecutive patients with CHB who underwent LB and ARFI elastography on the same day from November 2010 to March 2013 were prospectively recruited from three tertiary hospitals. Results: We analyzed 105 patients (median age of 47 years). The F0-1, F2, F3, and F4 fibrosis stages were identified in 27 (25.7%), 27 (25.7%), 21 (20.0%), and 30 (28.6%) patients, respectively. The areas under the receiver operating characteristics curves for ARFI elastography in assessing ≥F2, ≥F3, and F4 was 0.814, 0.848, and 0.752, respectively. The discordance of at least one stage between LB and ARFI was observed in 68 patients (64.8%) and of at least two stages in 16 patients (15.2%). In a multivariate analysis, advanced fibrosis stage (F3-4) was the only factor that was negatively correlated with one-stage discordance (p=0.042). Moreover, advanced fibrosis stage was negatively (p=0.016) correlated and body mass index (BMI) was positively (p=0.006) correlated with two-stage discordance. Conclusions: Advanced fibrosis stage (F3-4) was a predictor of nondiscordance between LB and ARFI elastography; BMI also influenced the accuracy of ARFI elastography.

Original languageEnglish
Pages (from-to)275-282
Number of pages8
JournalGut and liver
Volume10
Issue number2
DOIs
Publication statusPublished - 2016 Mar

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Elasticity Imaging Techniques
Chronic Hepatitis B
Acoustics
Radiation
Fibrosis
Biopsy
Liver
Body Mass Index
Tertiary Care Centers
ROC Curve
Liver Cirrhosis
Multivariate Analysis
beryllium trifluoride

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Park, Mi Sung ; Kim, Sun Wook ; Yoon, Ki Tae ; Kim, Seung Up ; Park, Soo Young ; Tak, Won Young ; Kweon, Young Oh ; Cho, Mong ; Kim, Beom Kyung ; Park, Jun Yong ; Kim, Do Young ; Ahn, Sang Hoon ; Han, Kwang Hyub. / Factors influencing the diagnostic accuracy of acoustic radiation force impulse elastography in patients with chronic hepatitis B. In: Gut and liver. 2016 ; Vol. 10, No. 2. pp. 275-282.
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title = "Factors influencing the diagnostic accuracy of acoustic radiation force impulse elastography in patients with chronic hepatitis B",
abstract = "Background/Aims: To determine factors predictive of discordance in staging liver fibrosis using liver biopsy (LB) and acoustic radiation force impulse (ARFI) elastography in patients with chronic hepatitis B (CHB). Methods: Consecutive patients with CHB who underwent LB and ARFI elastography on the same day from November 2010 to March 2013 were prospectively recruited from three tertiary hospitals. Results: We analyzed 105 patients (median age of 47 years). The F0-1, F2, F3, and F4 fibrosis stages were identified in 27 (25.7{\%}), 27 (25.7{\%}), 21 (20.0{\%}), and 30 (28.6{\%}) patients, respectively. The areas under the receiver operating characteristics curves for ARFI elastography in assessing ≥F2, ≥F3, and F4 was 0.814, 0.848, and 0.752, respectively. The discordance of at least one stage between LB and ARFI was observed in 68 patients (64.8{\%}) and of at least two stages in 16 patients (15.2{\%}). In a multivariate analysis, advanced fibrosis stage (F3-4) was the only factor that was negatively correlated with one-stage discordance (p=0.042). Moreover, advanced fibrosis stage was negatively (p=0.016) correlated and body mass index (BMI) was positively (p=0.006) correlated with two-stage discordance. Conclusions: Advanced fibrosis stage (F3-4) was a predictor of nondiscordance between LB and ARFI elastography; BMI also influenced the accuracy of ARFI elastography.",
author = "Park, {Mi Sung} and Kim, {Sun Wook} and Yoon, {Ki Tae} and Kim, {Seung Up} and Park, {Soo Young} and Tak, {Won Young} and Kweon, {Young Oh} and Mong Cho and Kim, {Beom Kyung} and Park, {Jun Yong} and Kim, {Do Young} and Ahn, {Sang Hoon} and Han, {Kwang Hyub}",
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Factors influencing the diagnostic accuracy of acoustic radiation force impulse elastography in patients with chronic hepatitis B. / Park, Mi Sung; Kim, Sun Wook; Yoon, Ki Tae; Kim, Seung Up; Park, Soo Young; Tak, Won Young; Kweon, Young Oh; Cho, Mong; Kim, Beom Kyung; Park, Jun Yong; Kim, Do Young; Ahn, Sang Hoon; Han, Kwang Hyub.

In: Gut and liver, Vol. 10, No. 2, 03.2016, p. 275-282.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Factors influencing the diagnostic accuracy of acoustic radiation force impulse elastography in patients with chronic hepatitis B

AU - Park, Mi Sung

AU - Kim, Sun Wook

AU - Yoon, Ki Tae

AU - Kim, Seung Up

AU - Park, Soo Young

AU - Tak, Won Young

AU - Kweon, Young Oh

AU - Cho, Mong

AU - Kim, Beom Kyung

AU - Park, Jun Yong

AU - Kim, Do Young

AU - Ahn, Sang Hoon

AU - Han, Kwang Hyub

PY - 2016/3

Y1 - 2016/3

N2 - Background/Aims: To determine factors predictive of discordance in staging liver fibrosis using liver biopsy (LB) and acoustic radiation force impulse (ARFI) elastography in patients with chronic hepatitis B (CHB). Methods: Consecutive patients with CHB who underwent LB and ARFI elastography on the same day from November 2010 to March 2013 were prospectively recruited from three tertiary hospitals. Results: We analyzed 105 patients (median age of 47 years). The F0-1, F2, F3, and F4 fibrosis stages were identified in 27 (25.7%), 27 (25.7%), 21 (20.0%), and 30 (28.6%) patients, respectively. The areas under the receiver operating characteristics curves for ARFI elastography in assessing ≥F2, ≥F3, and F4 was 0.814, 0.848, and 0.752, respectively. The discordance of at least one stage between LB and ARFI was observed in 68 patients (64.8%) and of at least two stages in 16 patients (15.2%). In a multivariate analysis, advanced fibrosis stage (F3-4) was the only factor that was negatively correlated with one-stage discordance (p=0.042). Moreover, advanced fibrosis stage was negatively (p=0.016) correlated and body mass index (BMI) was positively (p=0.006) correlated with two-stage discordance. Conclusions: Advanced fibrosis stage (F3-4) was a predictor of nondiscordance between LB and ARFI elastography; BMI also influenced the accuracy of ARFI elastography.

AB - Background/Aims: To determine factors predictive of discordance in staging liver fibrosis using liver biopsy (LB) and acoustic radiation force impulse (ARFI) elastography in patients with chronic hepatitis B (CHB). Methods: Consecutive patients with CHB who underwent LB and ARFI elastography on the same day from November 2010 to March 2013 were prospectively recruited from three tertiary hospitals. Results: We analyzed 105 patients (median age of 47 years). The F0-1, F2, F3, and F4 fibrosis stages were identified in 27 (25.7%), 27 (25.7%), 21 (20.0%), and 30 (28.6%) patients, respectively. The areas under the receiver operating characteristics curves for ARFI elastography in assessing ≥F2, ≥F3, and F4 was 0.814, 0.848, and 0.752, respectively. The discordance of at least one stage between LB and ARFI was observed in 68 patients (64.8%) and of at least two stages in 16 patients (15.2%). In a multivariate analysis, advanced fibrosis stage (F3-4) was the only factor that was negatively correlated with one-stage discordance (p=0.042). Moreover, advanced fibrosis stage was negatively (p=0.016) correlated and body mass index (BMI) was positively (p=0.006) correlated with two-stage discordance. Conclusions: Advanced fibrosis stage (F3-4) was a predictor of nondiscordance between LB and ARFI elastography; BMI also influenced the accuracy of ARFI elastography.

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