Factors influencing treatment outcome in patients with gastroesophageal reflux disease: Outcome of a prospective pragmatic trial in Asian patients

Khean L. Goh, Kee D. Choi, Myung Gyu Choi, Tsai Yuan Hsieh, Hwoon Yong Jung, Han Chung Lien, Jayaram Menon, Steven Mesenas, Hyojin Park, Bor Shyang Sheu, Justin C.Y. Wu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Predicting response to proton pump inhibitor (PPI) treatment can aid the effective management of gastroesophageal reflux disease (GERD). The aim was to investigate the predictors of symptomatic response to pantoprazole in Asian patients with GERD; the first study of its kind in Asian patients. Methods: Asian patients with GERD symptoms (N = 209) received pantoprazole 40 mg daily for 8 weeks in a multinational, prospective, open-label study. Response was assessed using ReQuest™. Baseline and demographic factors were examined using logistic regression to determine if they were related to treatment response. Results: Response rates were 44.3% (Week 4) and 63.6% (Week 8) in Asian patients versus 60.7% (P < 0.001) and 72.2% (P = 0.010) for the rest of the world. Higher response rates at 8 weeks occurred in patients with erosive reflux disease (ERD; 71.3%) versus those with non-erosive reflux disease (NERD) at baseline (48.5%). The presence of ERD (P = 0.0143) and lower ReQuest™-GI scores at baseline (P = 0.0222) were associated with response. Improvements in quality of life (QoL) and anxiety and depression at 4 and 8 weeks were associated with treatment response (both P < 0.0001). Patient satisfaction correlated with treatment response (P < 0.0001), and improvement in anxiety and depression (P < 0.0001) and QoL (P < 0.0001). Conclusions: Asian patients with GERD, especially those with NERD, may have lower response rates to PPIs than Western populations. ERD and less severe gastrointestinal symptoms may help to predict symptomatic responses to PPIs in Asian patients. Trial Registration: ClinicalTrial.gov identifier: NCT00312806.

Original languageEnglish
Article number156
JournalBMC Gastroenterology
Volume14
Issue number1
DOIs
Publication statusPublished - 2014 Sep 9

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Pragmatic Clinical Trials
Gastroesophageal Reflux
Anxiety
Quality of Life
Depression
Proton Pump Inhibitors
Therapeutics
Patient Satisfaction
Logistic Models
Demography

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Goh, Khean L. ; Choi, Kee D. ; Choi, Myung Gyu ; Hsieh, Tsai Yuan ; Jung, Hwoon Yong ; Lien, Han Chung ; Menon, Jayaram ; Mesenas, Steven ; Park, Hyojin ; Sheu, Bor Shyang ; Wu, Justin C.Y. / Factors influencing treatment outcome in patients with gastroesophageal reflux disease : Outcome of a prospective pragmatic trial in Asian patients. In: BMC Gastroenterology. 2014 ; Vol. 14, No. 1.
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abstract = "Background: Predicting response to proton pump inhibitor (PPI) treatment can aid the effective management of gastroesophageal reflux disease (GERD). The aim was to investigate the predictors of symptomatic response to pantoprazole in Asian patients with GERD; the first study of its kind in Asian patients. Methods: Asian patients with GERD symptoms (N = 209) received pantoprazole 40 mg daily for 8 weeks in a multinational, prospective, open-label study. Response was assessed using ReQuest™. Baseline and demographic factors were examined using logistic regression to determine if they were related to treatment response. Results: Response rates were 44.3{\%} (Week 4) and 63.6{\%} (Week 8) in Asian patients versus 60.7{\%} (P < 0.001) and 72.2{\%} (P = 0.010) for the rest of the world. Higher response rates at 8 weeks occurred in patients with erosive reflux disease (ERD; 71.3{\%}) versus those with non-erosive reflux disease (NERD) at baseline (48.5{\%}). The presence of ERD (P = 0.0143) and lower ReQuest™-GI scores at baseline (P = 0.0222) were associated with response. Improvements in quality of life (QoL) and anxiety and depression at 4 and 8 weeks were associated with treatment response (both P < 0.0001). Patient satisfaction correlated with treatment response (P < 0.0001), and improvement in anxiety and depression (P < 0.0001) and QoL (P < 0.0001). Conclusions: Asian patients with GERD, especially those with NERD, may have lower response rates to PPIs than Western populations. ERD and less severe gastrointestinal symptoms may help to predict symptomatic responses to PPIs in Asian patients. Trial Registration: ClinicalTrial.gov identifier: NCT00312806.",
author = "Goh, {Khean L.} and Choi, {Kee D.} and Choi, {Myung Gyu} and Hsieh, {Tsai Yuan} and Jung, {Hwoon Yong} and Lien, {Han Chung} and Jayaram Menon and Steven Mesenas and Hyojin Park and Sheu, {Bor Shyang} and Wu, {Justin C.Y.}",
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Factors influencing treatment outcome in patients with gastroesophageal reflux disease : Outcome of a prospective pragmatic trial in Asian patients. / Goh, Khean L.; Choi, Kee D.; Choi, Myung Gyu; Hsieh, Tsai Yuan; Jung, Hwoon Yong; Lien, Han Chung; Menon, Jayaram; Mesenas, Steven; Park, Hyojin; Sheu, Bor Shyang; Wu, Justin C.Y.

In: BMC Gastroenterology, Vol. 14, No. 1, 156, 09.09.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Factors influencing treatment outcome in patients with gastroesophageal reflux disease

T2 - Outcome of a prospective pragmatic trial in Asian patients

AU - Goh, Khean L.

AU - Choi, Kee D.

AU - Choi, Myung Gyu

AU - Hsieh, Tsai Yuan

AU - Jung, Hwoon Yong

AU - Lien, Han Chung

AU - Menon, Jayaram

AU - Mesenas, Steven

AU - Park, Hyojin

AU - Sheu, Bor Shyang

AU - Wu, Justin C.Y.

PY - 2014/9/9

Y1 - 2014/9/9

N2 - Background: Predicting response to proton pump inhibitor (PPI) treatment can aid the effective management of gastroesophageal reflux disease (GERD). The aim was to investigate the predictors of symptomatic response to pantoprazole in Asian patients with GERD; the first study of its kind in Asian patients. Methods: Asian patients with GERD symptoms (N = 209) received pantoprazole 40 mg daily for 8 weeks in a multinational, prospective, open-label study. Response was assessed using ReQuest™. Baseline and demographic factors were examined using logistic regression to determine if they were related to treatment response. Results: Response rates were 44.3% (Week 4) and 63.6% (Week 8) in Asian patients versus 60.7% (P < 0.001) and 72.2% (P = 0.010) for the rest of the world. Higher response rates at 8 weeks occurred in patients with erosive reflux disease (ERD; 71.3%) versus those with non-erosive reflux disease (NERD) at baseline (48.5%). The presence of ERD (P = 0.0143) and lower ReQuest™-GI scores at baseline (P = 0.0222) were associated with response. Improvements in quality of life (QoL) and anxiety and depression at 4 and 8 weeks were associated with treatment response (both P < 0.0001). Patient satisfaction correlated with treatment response (P < 0.0001), and improvement in anxiety and depression (P < 0.0001) and QoL (P < 0.0001). Conclusions: Asian patients with GERD, especially those with NERD, may have lower response rates to PPIs than Western populations. ERD and less severe gastrointestinal symptoms may help to predict symptomatic responses to PPIs in Asian patients. Trial Registration: ClinicalTrial.gov identifier: NCT00312806.

AB - Background: Predicting response to proton pump inhibitor (PPI) treatment can aid the effective management of gastroesophageal reflux disease (GERD). The aim was to investigate the predictors of symptomatic response to pantoprazole in Asian patients with GERD; the first study of its kind in Asian patients. Methods: Asian patients with GERD symptoms (N = 209) received pantoprazole 40 mg daily for 8 weeks in a multinational, prospective, open-label study. Response was assessed using ReQuest™. Baseline and demographic factors were examined using logistic regression to determine if they were related to treatment response. Results: Response rates were 44.3% (Week 4) and 63.6% (Week 8) in Asian patients versus 60.7% (P < 0.001) and 72.2% (P = 0.010) for the rest of the world. Higher response rates at 8 weeks occurred in patients with erosive reflux disease (ERD; 71.3%) versus those with non-erosive reflux disease (NERD) at baseline (48.5%). The presence of ERD (P = 0.0143) and lower ReQuest™-GI scores at baseline (P = 0.0222) were associated with response. Improvements in quality of life (QoL) and anxiety and depression at 4 and 8 weeks were associated with treatment response (both P < 0.0001). Patient satisfaction correlated with treatment response (P < 0.0001), and improvement in anxiety and depression (P < 0.0001) and QoL (P < 0.0001). Conclusions: Asian patients with GERD, especially those with NERD, may have lower response rates to PPIs than Western populations. ERD and less severe gastrointestinal symptoms may help to predict symptomatic responses to PPIs in Asian patients. Trial Registration: ClinicalTrial.gov identifier: NCT00312806.

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U2 - 10.1186/1471-230X-14-156

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