Factors predictive of cardiac events and restenosis after sirolimus-eluting stent implantation in small coronary arteries

Whan Lee Cheol, Jon Suh, Se Whan Lee, Duk Woo Park, Seung Hwan Lee, Young Hak Kim, Myeongki Hong, Jae Joong Kim, Seong Wook Park, Seung Jung Park

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objectives: Predictors of cardiac events and restenosis after sirolimus-eluting stent (SES) implantation in small coronary arteries were evaluated. Background: Although SES implantation has markedly reduced the risk of restenosis, small vessel disease remains a major cause of SES failure. Methods: We prospectively investigated the factors predictive of cardiac events and restenosis in 1,092 consecutive patients who received SES implantation for 1,269 lesions in small coronary arteries (≤2.8 mm). Follow-up angiography at 8 months was performed in 751 patients with 889 lesions (follow-up rate 70.3%). Results: Restenosis (diameter stenosis ≥ 50%) was angiographically documented in 65 patients with 77 lesions (8.7%): 55 focal (71.4%), 8 diffuse (10.4%), 2 diffuse proliferative (2.6%), and 12 total (15.6%). Lesion length, stent length, reference artery size, and in-stent restenotic lesions were univariate predictors of restenosis. By multivariate analysis, lesion length (OR 1.04; 95% CI 1.02-1.05; P < 0.001) and in-stent restenotic lesions (OR 3.38; 95% CI 1.80-6.35; P < 0.001) were significant independent predictors of restenosis. During follow-up (23.2 ± 7.9 months), there were 17 deaths (5 cardiac and 12 noncardiac), 5 nonfatal Q-wave myocardial infarctions, and 42 target lesion revascularizations. The cumulative probability of survival without major adveres cardiac events (MACE) was (96.8 ± 0.6)% at 1 year and (95.1 ± 0.7)% at 2 years. In multivariate analysia, lesion length (HR 1.04; 95% CI 1.01-1.07; P = 0.004) and in-stent restenotic lesions (HR 3.29; 95% CI 1.58-6.88; P = 0.001) were independently related to MACE. Conclusions: SES implantation in small coronary arteries is safe and effective, with lesion length having a major impact on restenosis and MACE.

Original languageEnglish
Pages (from-to)821-825
Number of pages5
JournalCatheterization and Cardiovascular Interventions
Volume69
Issue number6
DOIs
Publication statusPublished - 2007 May 1

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Sirolimus
Stents
Coronary Vessels
Angiography
Pathologic Constriction
Multivariate Analysis
Arteries
Myocardial Infarction
Survival

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Cheol, Whan Lee ; Suh, Jon ; Lee, Se Whan ; Park, Duk Woo ; Lee, Seung Hwan ; Kim, Young Hak ; Hong, Myeongki ; Kim, Jae Joong ; Park, Seong Wook ; Park, Seung Jung. / Factors predictive of cardiac events and restenosis after sirolimus-eluting stent implantation in small coronary arteries. In: Catheterization and Cardiovascular Interventions. 2007 ; Vol. 69, No. 6. pp. 821-825.
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title = "Factors predictive of cardiac events and restenosis after sirolimus-eluting stent implantation in small coronary arteries",
abstract = "Objectives: Predictors of cardiac events and restenosis after sirolimus-eluting stent (SES) implantation in small coronary arteries were evaluated. Background: Although SES implantation has markedly reduced the risk of restenosis, small vessel disease remains a major cause of SES failure. Methods: We prospectively investigated the factors predictive of cardiac events and restenosis in 1,092 consecutive patients who received SES implantation for 1,269 lesions in small coronary arteries (≤2.8 mm). Follow-up angiography at 8 months was performed in 751 patients with 889 lesions (follow-up rate 70.3{\%}). Results: Restenosis (diameter stenosis ≥ 50{\%}) was angiographically documented in 65 patients with 77 lesions (8.7{\%}): 55 focal (71.4{\%}), 8 diffuse (10.4{\%}), 2 diffuse proliferative (2.6{\%}), and 12 total (15.6{\%}). Lesion length, stent length, reference artery size, and in-stent restenotic lesions were univariate predictors of restenosis. By multivariate analysis, lesion length (OR 1.04; 95{\%} CI 1.02-1.05; P < 0.001) and in-stent restenotic lesions (OR 3.38; 95{\%} CI 1.80-6.35; P < 0.001) were significant independent predictors of restenosis. During follow-up (23.2 ± 7.9 months), there were 17 deaths (5 cardiac and 12 noncardiac), 5 nonfatal Q-wave myocardial infarctions, and 42 target lesion revascularizations. The cumulative probability of survival without major adveres cardiac events (MACE) was (96.8 ± 0.6){\%} at 1 year and (95.1 ± 0.7){\%} at 2 years. In multivariate analysia, lesion length (HR 1.04; 95{\%} CI 1.01-1.07; P = 0.004) and in-stent restenotic lesions (HR 3.29; 95{\%} CI 1.58-6.88; P = 0.001) were independently related to MACE. Conclusions: SES implantation in small coronary arteries is safe and effective, with lesion length having a major impact on restenosis and MACE.",
author = "Cheol, {Whan Lee} and Jon Suh and Lee, {Se Whan} and Park, {Duk Woo} and Lee, {Seung Hwan} and Kim, {Young Hak} and Myeongki Hong and Kim, {Jae Joong} and Park, {Seong Wook} and Park, {Seung Jung}",
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Factors predictive of cardiac events and restenosis after sirolimus-eluting stent implantation in small coronary arteries. / Cheol, Whan Lee; Suh, Jon; Lee, Se Whan; Park, Duk Woo; Lee, Seung Hwan; Kim, Young Hak; Hong, Myeongki; Kim, Jae Joong; Park, Seong Wook; Park, Seung Jung.

In: Catheterization and Cardiovascular Interventions, Vol. 69, No. 6, 01.05.2007, p. 821-825.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Factors predictive of cardiac events and restenosis after sirolimus-eluting stent implantation in small coronary arteries

AU - Cheol, Whan Lee

AU - Suh, Jon

AU - Lee, Se Whan

AU - Park, Duk Woo

AU - Lee, Seung Hwan

AU - Kim, Young Hak

AU - Hong, Myeongki

AU - Kim, Jae Joong

AU - Park, Seong Wook

AU - Park, Seung Jung

PY - 2007/5/1

Y1 - 2007/5/1

N2 - Objectives: Predictors of cardiac events and restenosis after sirolimus-eluting stent (SES) implantation in small coronary arteries were evaluated. Background: Although SES implantation has markedly reduced the risk of restenosis, small vessel disease remains a major cause of SES failure. Methods: We prospectively investigated the factors predictive of cardiac events and restenosis in 1,092 consecutive patients who received SES implantation for 1,269 lesions in small coronary arteries (≤2.8 mm). Follow-up angiography at 8 months was performed in 751 patients with 889 lesions (follow-up rate 70.3%). Results: Restenosis (diameter stenosis ≥ 50%) was angiographically documented in 65 patients with 77 lesions (8.7%): 55 focal (71.4%), 8 diffuse (10.4%), 2 diffuse proliferative (2.6%), and 12 total (15.6%). Lesion length, stent length, reference artery size, and in-stent restenotic lesions were univariate predictors of restenosis. By multivariate analysis, lesion length (OR 1.04; 95% CI 1.02-1.05; P < 0.001) and in-stent restenotic lesions (OR 3.38; 95% CI 1.80-6.35; P < 0.001) were significant independent predictors of restenosis. During follow-up (23.2 ± 7.9 months), there were 17 deaths (5 cardiac and 12 noncardiac), 5 nonfatal Q-wave myocardial infarctions, and 42 target lesion revascularizations. The cumulative probability of survival without major adveres cardiac events (MACE) was (96.8 ± 0.6)% at 1 year and (95.1 ± 0.7)% at 2 years. In multivariate analysia, lesion length (HR 1.04; 95% CI 1.01-1.07; P = 0.004) and in-stent restenotic lesions (HR 3.29; 95% CI 1.58-6.88; P = 0.001) were independently related to MACE. Conclusions: SES implantation in small coronary arteries is safe and effective, with lesion length having a major impact on restenosis and MACE.

AB - Objectives: Predictors of cardiac events and restenosis after sirolimus-eluting stent (SES) implantation in small coronary arteries were evaluated. Background: Although SES implantation has markedly reduced the risk of restenosis, small vessel disease remains a major cause of SES failure. Methods: We prospectively investigated the factors predictive of cardiac events and restenosis in 1,092 consecutive patients who received SES implantation for 1,269 lesions in small coronary arteries (≤2.8 mm). Follow-up angiography at 8 months was performed in 751 patients with 889 lesions (follow-up rate 70.3%). Results: Restenosis (diameter stenosis ≥ 50%) was angiographically documented in 65 patients with 77 lesions (8.7%): 55 focal (71.4%), 8 diffuse (10.4%), 2 diffuse proliferative (2.6%), and 12 total (15.6%). Lesion length, stent length, reference artery size, and in-stent restenotic lesions were univariate predictors of restenosis. By multivariate analysis, lesion length (OR 1.04; 95% CI 1.02-1.05; P < 0.001) and in-stent restenotic lesions (OR 3.38; 95% CI 1.80-6.35; P < 0.001) were significant independent predictors of restenosis. During follow-up (23.2 ± 7.9 months), there were 17 deaths (5 cardiac and 12 noncardiac), 5 nonfatal Q-wave myocardial infarctions, and 42 target lesion revascularizations. The cumulative probability of survival without major adveres cardiac events (MACE) was (96.8 ± 0.6)% at 1 year and (95.1 ± 0.7)% at 2 years. In multivariate analysia, lesion length (HR 1.04; 95% CI 1.01-1.07; P = 0.004) and in-stent restenotic lesions (HR 3.29; 95% CI 1.58-6.88; P = 0.001) were independently related to MACE. Conclusions: SES implantation in small coronary arteries is safe and effective, with lesion length having a major impact on restenosis and MACE.

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SN - 1522-1946

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