Abstract
Objectives: Predictors of cardiac events and restenosis after sirolimus-eluting stent (SES) implantation in small coronary arteries were evaluated. Background: Although SES implantation has markedly reduced the risk of restenosis, small vessel disease remains a major cause of SES failure. Methods: We prospectively investigated the factors predictive of cardiac events and restenosis in 1,092 consecutive patients who received SES implantation for 1,269 lesions in small coronary arteries (≤2.8 mm). Follow-up angiography at 8 months was performed in 751 patients with 889 lesions (follow-up rate 70.3%). Results: Restenosis (diameter stenosis ≥ 50%) was angiographically documented in 65 patients with 77 lesions (8.7%): 55 focal (71.4%), 8 diffuse (10.4%), 2 diffuse proliferative (2.6%), and 12 total (15.6%). Lesion length, stent length, reference artery size, and in-stent restenotic lesions were univariate predictors of restenosis. By multivariate analysis, lesion length (OR 1.04; 95% CI 1.02-1.05; P < 0.001) and in-stent restenotic lesions (OR 3.38; 95% CI 1.80-6.35; P < 0.001) were significant independent predictors of restenosis. During follow-up (23.2 ± 7.9 months), there were 17 deaths (5 cardiac and 12 noncardiac), 5 nonfatal Q-wave myocardial infarctions, and 42 target lesion revascularizations. The cumulative probability of survival without major adveres cardiac events (MACE) was (96.8 ± 0.6)% at 1 year and (95.1 ± 0.7)% at 2 years. In multivariate analysia, lesion length (HR 1.04; 95% CI 1.01-1.07; P = 0.004) and in-stent restenotic lesions (HR 3.29; 95% CI 1.58-6.88; P = 0.001) were independently related to MACE. Conclusions: SES implantation in small coronary arteries is safe and effective, with lesion length having a major impact on restenosis and MACE.
| Original language | English |
|---|---|
| Pages (from-to) | 821-825 |
| Number of pages | 5 |
| Journal | Catheterization and Cardiovascular Interventions |
| Volume | 69 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2007 May 1 |
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All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine
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Factors predictive of cardiac events and restenosis after sirolimus-eluting stent implantation in small coronary arteries. / Cheol, Whan Lee; Suh, Jon; Lee, Se Whan; Park, Duk Woo; Lee, Seung Hwan; Kim, Young Hak; Hong, Myeongki; Kim, Jae Joong; Park, Seong Wook; Park, Seung Jung.
In: Catheterization and Cardiovascular Interventions, Vol. 69, No. 6, 01.05.2007, p. 821-825.Research output: Contribution to journal › Article
TY - JOUR
T1 - Factors predictive of cardiac events and restenosis after sirolimus-eluting stent implantation in small coronary arteries
AU - Cheol, Whan Lee
AU - Suh, Jon
AU - Lee, Se Whan
AU - Park, Duk Woo
AU - Lee, Seung Hwan
AU - Kim, Young Hak
AU - Hong, Myeongki
AU - Kim, Jae Joong
AU - Park, Seong Wook
AU - Park, Seung Jung
PY - 2007/5/1
Y1 - 2007/5/1
N2 - Objectives: Predictors of cardiac events and restenosis after sirolimus-eluting stent (SES) implantation in small coronary arteries were evaluated. Background: Although SES implantation has markedly reduced the risk of restenosis, small vessel disease remains a major cause of SES failure. Methods: We prospectively investigated the factors predictive of cardiac events and restenosis in 1,092 consecutive patients who received SES implantation for 1,269 lesions in small coronary arteries (≤2.8 mm). Follow-up angiography at 8 months was performed in 751 patients with 889 lesions (follow-up rate 70.3%). Results: Restenosis (diameter stenosis ≥ 50%) was angiographically documented in 65 patients with 77 lesions (8.7%): 55 focal (71.4%), 8 diffuse (10.4%), 2 diffuse proliferative (2.6%), and 12 total (15.6%). Lesion length, stent length, reference artery size, and in-stent restenotic lesions were univariate predictors of restenosis. By multivariate analysis, lesion length (OR 1.04; 95% CI 1.02-1.05; P < 0.001) and in-stent restenotic lesions (OR 3.38; 95% CI 1.80-6.35; P < 0.001) were significant independent predictors of restenosis. During follow-up (23.2 ± 7.9 months), there were 17 deaths (5 cardiac and 12 noncardiac), 5 nonfatal Q-wave myocardial infarctions, and 42 target lesion revascularizations. The cumulative probability of survival without major adveres cardiac events (MACE) was (96.8 ± 0.6)% at 1 year and (95.1 ± 0.7)% at 2 years. In multivariate analysia, lesion length (HR 1.04; 95% CI 1.01-1.07; P = 0.004) and in-stent restenotic lesions (HR 3.29; 95% CI 1.58-6.88; P = 0.001) were independently related to MACE. Conclusions: SES implantation in small coronary arteries is safe and effective, with lesion length having a major impact on restenosis and MACE.
AB - Objectives: Predictors of cardiac events and restenosis after sirolimus-eluting stent (SES) implantation in small coronary arteries were evaluated. Background: Although SES implantation has markedly reduced the risk of restenosis, small vessel disease remains a major cause of SES failure. Methods: We prospectively investigated the factors predictive of cardiac events and restenosis in 1,092 consecutive patients who received SES implantation for 1,269 lesions in small coronary arteries (≤2.8 mm). Follow-up angiography at 8 months was performed in 751 patients with 889 lesions (follow-up rate 70.3%). Results: Restenosis (diameter stenosis ≥ 50%) was angiographically documented in 65 patients with 77 lesions (8.7%): 55 focal (71.4%), 8 diffuse (10.4%), 2 diffuse proliferative (2.6%), and 12 total (15.6%). Lesion length, stent length, reference artery size, and in-stent restenotic lesions were univariate predictors of restenosis. By multivariate analysis, lesion length (OR 1.04; 95% CI 1.02-1.05; P < 0.001) and in-stent restenotic lesions (OR 3.38; 95% CI 1.80-6.35; P < 0.001) were significant independent predictors of restenosis. During follow-up (23.2 ± 7.9 months), there were 17 deaths (5 cardiac and 12 noncardiac), 5 nonfatal Q-wave myocardial infarctions, and 42 target lesion revascularizations. The cumulative probability of survival without major adveres cardiac events (MACE) was (96.8 ± 0.6)% at 1 year and (95.1 ± 0.7)% at 2 years. In multivariate analysia, lesion length (HR 1.04; 95% CI 1.01-1.07; P = 0.004) and in-stent restenotic lesions (HR 3.29; 95% CI 1.58-6.88; P = 0.001) were independently related to MACE. Conclusions: SES implantation in small coronary arteries is safe and effective, with lesion length having a major impact on restenosis and MACE.
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U2 - 10.1002/ccd.21019
DO - 10.1002/ccd.21019
M3 - Article
VL - 69
SP - 821
EP - 825
JO - Catheterization and Cardiovascular Interventions
JF - Catheterization and Cardiovascular Interventions
SN - 1522-1946
IS - 6
ER -