Factors predictive of response to interferon-α therapy in hepatitis C virus type 1b infection

Byung Il Yeh, KwangHyub Han, Hyean Woo Lee, Joon Hyung Sohn, Wang-Shick Ryu, Do Jun Yoon, Joonho Yoon, Hyun Won Kim, Indeok Kong, Sei Jin Chang, Jong Whan Choi

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Abstract

Interferon-α (IFN-α) has been used to treat hepatitis C Virus (HCV)-induced infection but has been effective in only about half of all patients. It is suggested that the different responses to IFN-α treatment in HCV infection may be influenced by HCV genotypes, HCV RNA titer at the beginning of IFN-α therapy, and the sequences of the interferon sensitivity determining region (ISDR). However, there have also been reports showing that these have no relation to an IFN-α effect. In a previous study, it was found that the nucleotide sequence variation in the hypervariable region (HVR) 1 of the HCV could predict the effect of IFN-α. In the present investigation, an attempt was made to determine the predictive factors of IFN-α therapy. Twenty-six patients with HCV infection were treated with IFN-α. Among these, 13 patients recovered after 3 to 6 months of IFN-α treatment, although the other 13 patients showed no response after 6 months of treatment with IFN-α. In order to determine the predictive factors of IFN-α therapy, the ALT levels, HCV genotypes, HCV serum titer, and the quasispecies of HVR 1 were compared between responders and non-responders. It is suggested that the variation in the HVR 1 and HCV serum titer can be used to predict the effect of IFN-α.

Original languageEnglish
Pages (from-to)481-487
Number of pages7
JournalJournal of Medical Virology
Volume66
Issue number4
DOIs
Publication statusPublished - 2002 Mar 19

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Virus Diseases
Hepacivirus
Interferons
Therapeutics
Viral Load
Genotype
Serum
RNA

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Yeh, Byung Il ; Han, KwangHyub ; Lee, Hyean Woo ; Sohn, Joon Hyung ; Ryu, Wang-Shick ; Yoon, Do Jun ; Yoon, Joonho ; Kim, Hyun Won ; Kong, Indeok ; Chang, Sei Jin ; Choi, Jong Whan. / Factors predictive of response to interferon-α therapy in hepatitis C virus type 1b infection. In: Journal of Medical Virology. 2002 ; Vol. 66, No. 4. pp. 481-487.
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Factors predictive of response to interferon-α therapy in hepatitis C virus type 1b infection. / Yeh, Byung Il; Han, KwangHyub; Lee, Hyean Woo; Sohn, Joon Hyung; Ryu, Wang-Shick; Yoon, Do Jun; Yoon, Joonho; Kim, Hyun Won; Kong, Indeok; Chang, Sei Jin; Choi, Jong Whan.

In: Journal of Medical Virology, Vol. 66, No. 4, 19.03.2002, p. 481-487.

Research output: Contribution to journalArticle

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