Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B

Seungup Kim, Y. S. Seo, J. Y. Cheong, M. Y. Kim, J. K. Kim, S. H. Um, S. W. Cho, S. K. Paik, K. S. Lee, KwangHyub Han, SangHoon Ahn

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Abstract

Aliment Pharmacol Ther 2010; 32: 498-505 SummaryBackground Interquartile rangemedian value (IQRM) of liver stiffness measurement (LSM) is a factor in chronic hepatitis C (CHC) leading to over estimation of fibrosis by Fibroscan. Aim To investigate factors that affect the accuracy of LSM in chronic hepatitis B (CHB). Methods One hundred and ninety-nine patients were enrolled. Only procedures yielding ≥10 valid measurements were considered reliable. Liver fibrosis was evaluated using the Batts and Ludwig system. Liver biopsy (LB) specimens <15 mm were considered ineligible. Results The mean age (142 men and 57 women) was 40.1 years. A significant discordance (discordance of at least two stages between LB and LSM) was identified in 38 (19.1%) and 47 (23.6%) patients respectively, according to Marcellin et al. and Chan et al.'s cutoff values. In multivariate analyses, BMI and fibrosis stage (F0-2 vs. F3-4) were identified as independent predictors for significant discordance (P = 0.040; hazard ratio [HR], 1.126; 95% confidence interval [CI], 1.005-1.261 and P = 0.036; HR, 0.450; 95% CI, 0.213-0.949 respectively) with Marcellin et al.'s cutoffs, whereas fibrosis stage was the only independent predictor (P = 0.004; HR, 0.300; 95% CI, 0.131-0.685) with Chan's cutoffs. Conclusions Success rate and IQRM were not predictive factors of the accuracy for diagnosing liver fibrosis by Fibroscan in CHB. Fibrosis stage (F0-2) was the only factor to predict significant discordance between LB and LSM.

Original languageEnglish
Pages (from-to)498-505
Number of pages8
JournalAlimentary Pharmacology and Therapeutics
Volume32
Issue number3
DOIs
Publication statusPublished - 2010 Aug 1

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Chronic Hepatitis B
Liver Cirrhosis
Liver
Fibrosis
Confidence Intervals
Biopsy
Chronic Hepatitis C
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

Cite this

Kim, Seungup ; Seo, Y. S. ; Cheong, J. Y. ; Kim, M. Y. ; Kim, J. K. ; Um, S. H. ; Cho, S. W. ; Paik, S. K. ; Lee, K. S. ; Han, KwangHyub ; Ahn, SangHoon. / Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B. In: Alimentary Pharmacology and Therapeutics. 2010 ; Vol. 32, No. 3. pp. 498-505.
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title = "Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B",
abstract = "Aliment Pharmacol Ther 2010; 32: 498-505 SummaryBackground Interquartile rangemedian value (IQRM) of liver stiffness measurement (LSM) is a factor in chronic hepatitis C (CHC) leading to over estimation of fibrosis by Fibroscan. Aim To investigate factors that affect the accuracy of LSM in chronic hepatitis B (CHB). Methods One hundred and ninety-nine patients were enrolled. Only procedures yielding ≥10 valid measurements were considered reliable. Liver fibrosis was evaluated using the Batts and Ludwig system. Liver biopsy (LB) specimens <15 mm were considered ineligible. Results The mean age (142 men and 57 women) was 40.1 years. A significant discordance (discordance of at least two stages between LB and LSM) was identified in 38 (19.1{\%}) and 47 (23.6{\%}) patients respectively, according to Marcellin et al. and Chan et al.'s cutoff values. In multivariate analyses, BMI and fibrosis stage (F0-2 vs. F3-4) were identified as independent predictors for significant discordance (P = 0.040; hazard ratio [HR], 1.126; 95{\%} confidence interval [CI], 1.005-1.261 and P = 0.036; HR, 0.450; 95{\%} CI, 0.213-0.949 respectively) with Marcellin et al.'s cutoffs, whereas fibrosis stage was the only independent predictor (P = 0.004; HR, 0.300; 95{\%} CI, 0.131-0.685) with Chan's cutoffs. Conclusions Success rate and IQRM were not predictive factors of the accuracy for diagnosing liver fibrosis by Fibroscan in CHB. Fibrosis stage (F0-2) was the only factor to predict significant discordance between LB and LSM.",
author = "Seungup Kim and Seo, {Y. S.} and Cheong, {J. Y.} and Kim, {M. Y.} and Kim, {J. K.} and Um, {S. H.} and Cho, {S. W.} and Paik, {S. K.} and Lee, {K. S.} and KwangHyub Han and SangHoon Ahn",
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Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B. / Kim, Seungup; Seo, Y. S.; Cheong, J. Y.; Kim, M. Y.; Kim, J. K.; Um, S. H.; Cho, S. W.; Paik, S. K.; Lee, K. S.; Han, KwangHyub; Ahn, SangHoon.

In: Alimentary Pharmacology and Therapeutics, Vol. 32, No. 3, 01.08.2010, p. 498-505.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B

AU - Kim, Seungup

AU - Seo, Y. S.

AU - Cheong, J. Y.

AU - Kim, M. Y.

AU - Kim, J. K.

AU - Um, S. H.

AU - Cho, S. W.

AU - Paik, S. K.

AU - Lee, K. S.

AU - Han, KwangHyub

AU - Ahn, SangHoon

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N2 - Aliment Pharmacol Ther 2010; 32: 498-505 SummaryBackground Interquartile rangemedian value (IQRM) of liver stiffness measurement (LSM) is a factor in chronic hepatitis C (CHC) leading to over estimation of fibrosis by Fibroscan. Aim To investigate factors that affect the accuracy of LSM in chronic hepatitis B (CHB). Methods One hundred and ninety-nine patients were enrolled. Only procedures yielding ≥10 valid measurements were considered reliable. Liver fibrosis was evaluated using the Batts and Ludwig system. Liver biopsy (LB) specimens <15 mm were considered ineligible. Results The mean age (142 men and 57 women) was 40.1 years. A significant discordance (discordance of at least two stages between LB and LSM) was identified in 38 (19.1%) and 47 (23.6%) patients respectively, according to Marcellin et al. and Chan et al.'s cutoff values. In multivariate analyses, BMI and fibrosis stage (F0-2 vs. F3-4) were identified as independent predictors for significant discordance (P = 0.040; hazard ratio [HR], 1.126; 95% confidence interval [CI], 1.005-1.261 and P = 0.036; HR, 0.450; 95% CI, 0.213-0.949 respectively) with Marcellin et al.'s cutoffs, whereas fibrosis stage was the only independent predictor (P = 0.004; HR, 0.300; 95% CI, 0.131-0.685) with Chan's cutoffs. Conclusions Success rate and IQRM were not predictive factors of the accuracy for diagnosing liver fibrosis by Fibroscan in CHB. Fibrosis stage (F0-2) was the only factor to predict significant discordance between LB and LSM.

AB - Aliment Pharmacol Ther 2010; 32: 498-505 SummaryBackground Interquartile rangemedian value (IQRM) of liver stiffness measurement (LSM) is a factor in chronic hepatitis C (CHC) leading to over estimation of fibrosis by Fibroscan. Aim To investigate factors that affect the accuracy of LSM in chronic hepatitis B (CHB). Methods One hundred and ninety-nine patients were enrolled. Only procedures yielding ≥10 valid measurements were considered reliable. Liver fibrosis was evaluated using the Batts and Ludwig system. Liver biopsy (LB) specimens <15 mm were considered ineligible. Results The mean age (142 men and 57 women) was 40.1 years. A significant discordance (discordance of at least two stages between LB and LSM) was identified in 38 (19.1%) and 47 (23.6%) patients respectively, according to Marcellin et al. and Chan et al.'s cutoff values. In multivariate analyses, BMI and fibrosis stage (F0-2 vs. F3-4) were identified as independent predictors for significant discordance (P = 0.040; hazard ratio [HR], 1.126; 95% confidence interval [CI], 1.005-1.261 and P = 0.036; HR, 0.450; 95% CI, 0.213-0.949 respectively) with Marcellin et al.'s cutoffs, whereas fibrosis stage was the only independent predictor (P = 0.004; HR, 0.300; 95% CI, 0.131-0.685) with Chan's cutoffs. Conclusions Success rate and IQRM were not predictive factors of the accuracy for diagnosing liver fibrosis by Fibroscan in CHB. Fibrosis stage (F0-2) was the only factor to predict significant discordance between LB and LSM.

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