False-positive rate of a "fourth-generation" HIV antigen/antibody combination assay in an area of low HIV prevalence

Sinyoung Kim, Jong Han Lee, Jun Yong Choi, June Myung Kim, Hyon Suk Kim

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We retrospectively analyzed the performance of the Architect HIV antigen/antibody (Ag/Ab) combination assay in a tertiary health care center with a situation of low HIV prevalence. The specificity and positive predictive value (PPV) were 99.78% and 31.21%, respectively. However, the specificity and PPV could increase to 99.99% and 89.70% using an arbitrary cutoff value.

Original languageEnglish
Pages (from-to)1642-1644
Number of pages3
JournalClinical and Vaccine Immunology
Issue number10
Publication statusPublished - 2010 Oct 1


All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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