Fast 3D 1H MRSI of the corticospinal tract in pediatric brain

Dong Hyun Kim, Meng Gu, Charles Cunningham, Albert Chen, Fiona Baumer, Orit A. Glenn, Daniel B. Vigneron, Daniel Mark Spielman, Anthony James Barkovich

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Abstract

Purpose: To develop a 1H magnetic resonance spectroscopic imaging (MRSI) sequence that can be used to image infants/children at 3T and by combining it with diffusion tensor imaging (DTI) tractography, extract relevant metabolic information corresponding to the corticospinal tract (CST). Materials and Methods: A fast 3D MRSI sequence was developed for pediatric neuroimaging at 3T using spiral k-space readout and dual band RF pulses (32 × 32 × 8 cm field of view [FOV], 1 cc iso-resolution, TR/TE = 1500/130, 6:24 minute scan). Using DTI tractography to identify the motor tracts, spectra were extracted from the CSTs and quantified. Initial data from infants/children with suspected motor delay (n = 5) and age-matched controls (n = 3) were collected and N-acetylaspartate (NAA) ratios were quantified. Results: The average signal-to-noise ratio of the NAA peak from the studies was ≈22. Metabolite profiles were successfully acquired from the CST by using DTI tractography. Decreased NAA ratios in those with motor delay compared to controls of ≈10% at the CST were observed. Conclusion: A fast and robust 3D MRSI technique targeted for pediatric neuroimaging has been developed. By combining with DTI tractography, metabolic information from the CSTs can be retrieved and estimated. By combining DTI and 3D MRSI, spectral information from various tracts can be obtained and processed.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume29
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

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All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Kim, D. H., Gu, M., Cunningham, C., Chen, A., Baumer, F., Glenn, O. A., Vigneron, D. B., Spielman, D. M., & Barkovich, A. J. (2009). Fast 3D 1H MRSI of the corticospinal tract in pediatric brain. Journal of Magnetic Resonance Imaging, 29(1), 1-6. https://doi.org/10.1002/jmri.21394