By using the microscopic Beer–Lambert law (MBL), we propose a fast and effective analysis method for retrieving the absorption coefficient changes of a sample from broadband frequency-domain diffuse optical spectroscopy (FD-DOS) or frequency-domain near-infrared spectroscopy (FD-NIRS) data. To verify the advantages of our proposed method, we built a broadband frequency-domain single-distance diffuse optical imaging (DOI) system for measuring the amplitude and the phase of transmitted light. Fifteen liquid phantoms with different absorption and scattering coefficients are prepared, and the changes in the absorption coefficient Δμa are retrieved by using the conventional nonlinear least-squares fitting (NLSF) and the proposed MBL methods. Results show that the computation time and the precision of the MBL method are much better than those of the NLSF method, respectively.
|Publication status||Published - 2022 Oct 1|
Bibliographical noteFunding Information:
National Research Foundation of Korea (NRF) through the Basic Science Program ( NRF-2021R1A2C2009090 ); Korea Institute for Advancement of Technology (KIAT) and the Swiss Innovation Agency (Innosuisse) through S. Korea–Switzerland Joint Innovation Project ( P0011925 ).
© 2022 Elsevier B.V.
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Physical and Theoretical Chemistry
- Electrical and Electronic Engineering