Fate of acute heart failure patients with mid-range ejection fraction

KorAHF Registry

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The outcomes of heart failure (HF) with mid-range ejection fraction (HFmrEF) have been rarely studied, and follow-up data on left ventricular ejection fraction (LVEF) are scarse. Methods and Results: Patients were selected from a prospective multicenter registry of patients hospitalized for acute HF and then classified in the improved group if they exhibited %LVEF change ≥5 with follow-up LVEF ≥50%. Follow-up LVEF reported at least 90 days after discharge was used for classification. Of the 3,085 patients with acute HF, 454 were classified in the HFmrEF, and 276 had follow-up data. Of these 276 patients, 34.1% were classified in the improved group. Multivariate analysis revealed that hypertension, higher heart rate, lower serum sodium level, and maintenance therapy with β-blocker were associated with improved LVEF. The survival rate was significantly higher in the improved group than in the other groups. Young age and maintenance therapy with renin-angiotensin system blockers or aldosterone antagonists were significantly associated with better survival in HFmrEF. Conclusions: One-third of HFmrEF patients showed improved LVEF; moreover, the survival rate in the improved group was higher than the other groups. Renin-angiotensin system blockers and aldosterone antagonists could improve the survival of HFmrEF patients.

Original languageEnglish
Pages (from-to)2071-2078
Number of pages8
JournalCirculation Journal
Volume82
Issue number8
DOIs
Publication statusPublished - 2018 Jan 1

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Stroke Volume
Heart Failure
Mineralocorticoid Receptor Antagonists
Renin-Angiotensin System
Survival Rate
Survival
Registries
Multivariate Analysis
Heart Rate
Sodium
Hypertension
Therapeutics
Serum

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

KorAHF Registry. / Fate of acute heart failure patients with mid-range ejection fraction. In: Circulation Journal. 2018 ; Vol. 82, No. 8. pp. 2071-2078.
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abstract = "Background: The outcomes of heart failure (HF) with mid-range ejection fraction (HFmrEF) have been rarely studied, and follow-up data on left ventricular ejection fraction (LVEF) are scarse. Methods and Results: Patients were selected from a prospective multicenter registry of patients hospitalized for acute HF and then classified in the improved group if they exhibited {\%}LVEF change ≥5 with follow-up LVEF ≥50{\%}. Follow-up LVEF reported at least 90 days after discharge was used for classification. Of the 3,085 patients with acute HF, 454 were classified in the HFmrEF, and 276 had follow-up data. Of these 276 patients, 34.1{\%} were classified in the improved group. Multivariate analysis revealed that hypertension, higher heart rate, lower serum sodium level, and maintenance therapy with β-blocker were associated with improved LVEF. The survival rate was significantly higher in the improved group than in the other groups. Young age and maintenance therapy with renin-angiotensin system blockers or aldosterone antagonists were significantly associated with better survival in HFmrEF. Conclusions: One-third of HFmrEF patients showed improved LVEF; moreover, the survival rate in the improved group was higher than the other groups. Renin-angiotensin system blockers and aldosterone antagonists could improve the survival of HFmrEF patients.",
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Fate of acute heart failure patients with mid-range ejection fraction. / KorAHF Registry.

In: Circulation Journal, Vol. 82, No. 8, 01.01.2018, p. 2071-2078.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Fate of acute heart failure patients with mid-range ejection fraction

AU - KorAHF Registry

AU - Gwag, Hye Bin

AU - Lee, Ga Yeon

AU - Choi, Jin Oh

AU - Lee, Hae Young

AU - Kim, Jae Joong

AU - Hwang, Kyung Kuk

AU - Chae, Shung Chull

AU - Baek, Sang Hong

AU - kang, seokmin

AU - Choi, Dong Ju

AU - Yoo, Byungsu

AU - Kim, Kye Hun

AU - Park, Hyun Young

AU - Cho, Myeong Chan

AU - Oh, Byung Hee

AU - Jeon, Eun Seok

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: The outcomes of heart failure (HF) with mid-range ejection fraction (HFmrEF) have been rarely studied, and follow-up data on left ventricular ejection fraction (LVEF) are scarse. Methods and Results: Patients were selected from a prospective multicenter registry of patients hospitalized for acute HF and then classified in the improved group if they exhibited %LVEF change ≥5 with follow-up LVEF ≥50%. Follow-up LVEF reported at least 90 days after discharge was used for classification. Of the 3,085 patients with acute HF, 454 were classified in the HFmrEF, and 276 had follow-up data. Of these 276 patients, 34.1% were classified in the improved group. Multivariate analysis revealed that hypertension, higher heart rate, lower serum sodium level, and maintenance therapy with β-blocker were associated with improved LVEF. The survival rate was significantly higher in the improved group than in the other groups. Young age and maintenance therapy with renin-angiotensin system blockers or aldosterone antagonists were significantly associated with better survival in HFmrEF. Conclusions: One-third of HFmrEF patients showed improved LVEF; moreover, the survival rate in the improved group was higher than the other groups. Renin-angiotensin system blockers and aldosterone antagonists could improve the survival of HFmrEF patients.

AB - Background: The outcomes of heart failure (HF) with mid-range ejection fraction (HFmrEF) have been rarely studied, and follow-up data on left ventricular ejection fraction (LVEF) are scarse. Methods and Results: Patients were selected from a prospective multicenter registry of patients hospitalized for acute HF and then classified in the improved group if they exhibited %LVEF change ≥5 with follow-up LVEF ≥50%. Follow-up LVEF reported at least 90 days after discharge was used for classification. Of the 3,085 patients with acute HF, 454 were classified in the HFmrEF, and 276 had follow-up data. Of these 276 patients, 34.1% were classified in the improved group. Multivariate analysis revealed that hypertension, higher heart rate, lower serum sodium level, and maintenance therapy with β-blocker were associated with improved LVEF. The survival rate was significantly higher in the improved group than in the other groups. Young age and maintenance therapy with renin-angiotensin system blockers or aldosterone antagonists were significantly associated with better survival in HFmrEF. Conclusions: One-third of HFmrEF patients showed improved LVEF; moreover, the survival rate in the improved group was higher than the other groups. Renin-angiotensin system blockers and aldosterone antagonists could improve the survival of HFmrEF patients.

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U2 - 10.1253/circj.CJ-17-1389

DO - 10.1253/circj.CJ-17-1389

M3 - Article

C2 - 29681584

AN - SCOPUS:85050638752

VL - 82

SP - 2071

EP - 2078

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 8

ER -