Fatty acid derivatives isolated from the oil of persea americana (Avocado) protects against neomycin-induced hair cell damage

Seon Ju Park, Seo Yule Jeong, Youn Hee Nam, Jun Hyung Park, Isabel Rodriguez, Ji Heon Shim, Tamanna Yasmin, Hee Jae Kwak, Youngse Oh, Mira Oh, Kye Wan Lee, Jung Suk Lee, Do Hoon Kim, Yu Hwa Park, In Seok Moon, Se Young Choung, Kwang Won Jeong, Bin Na Hong, Seung Hyun Kim, Tong Ho Kang

Research output: Contribution to journalArticlepeer-review

Abstract

Avocado oil is beneficial to human health and has been reported to have beneficial effects on sensorineural hearing loss (SNHL). However, the compounds in avocado oil that affect SNHL have not been identified. In this study, we identified 20 compounds from avocado oil, including two new and 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of the isolated compounds for improving SNHL was investigated in an ototoxic zebrafish model. The two new compounds, namely (2R,4R,6Z)-1,2,4-trihydroxynonadec-6-ene and (2R,4R)-1,2,4-trihydroxyheptadecadi-14,16-ene (compounds 1 and 2), as well as compounds 7, 9, 14, 17 and 19 showed significant improvement in damaged hair cells in toxic zebrafish. These results led to the conclusion that compounds from avocado oil as well as oil itself have a regenerative effect on damaged otic hair cells in ototoxic zebrafish.

Original languageEnglish
Article number171
Pages (from-to)1-8
Number of pages8
JournalPlants
Volume10
Issue number1
DOIs
Publication statusPublished - 2021 Jan

Bibliographical note

Funding Information:
Funding: This work was supported by the Technology Innovation Program (10080691, Development of an individual approval health functional food and global product; protection of hearing loss and improvement of auditory function for the people with light to moderate hearing loss (26–55 dB of pure tone audiometry threshold) using avocado fraction) funded By the Ministry of Trade, Industry & Energy (MOTIE, Korea).

Funding Information:
This work was supported by the Technology Innovation Program (10080691, Development of an individual approval health functional food and global product; protection of hearing loss and improvement of auditory function for the people with light to moderate hearing loss (26?55 dB of pure tone audiometry threshold) using avocado fraction) funded By the Ministry of Trade, Industry & Energy (MOTIE, Korea).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Plant Science

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