Fatty liver associated with metabolic derangement in patients with chronic kidney disease: A controlled attenuation parameter study

Chang Yun Yoon, Misol Lee, Seung Up Kim, Hyunsun Lim, Tae Ik Chang, Youn Kyung Kee, Seung Gyu Han, In Mee Han, Young Eun Kwon, Kyoung Sook Park, Mi Jung Lee, Jung Tak Park, Seung Hyeok Han, Sang Hoon Ahn, Shin Wook Kang, Tae Hyun Yoo

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5 Citations (Scopus)


Background: Hepatic steatosis measured with controlled attenuation parameter (CAP) using transient elastography predicts metabolic syndrome in the general population. We investigated whether CAP predicted metabolic syndrome in chronic kidney disease patients. Methods: CAP was measured with transient elastography in 465 predialysis chronic kidney disease patients (mean age, 57.5 years). Results: The median CAP value was 239 (202-274) dB/m. In 195 (41.9%) patients with metabolic syndrome, diabetes mellitus was more prevalent (105 [53.8%] vs. 71 [26.3%], P < 0.001), with significantly increased urine albumin-to-creatinine ratio (184 [38-706] vs. 56 [16-408] mg/g Cr, P = 0.003), high sensitivity C-reactive protein levels (5.4 [1.4-28.2] vs. 1.7 [0.6-9.9] mg/L, P < 0.001), and CAP (248 [210-302] vs. 226 [196-259] dB/m, P < 0.001). In multiple linear regression analysis, CAP was independently related to body mass index (β = 0.742, P < 0.001), triglyceride levels (β = 2.034, P < 0.001), estimated glomerular filtration rate (β = 0.316, P = 0.001), serum albumin (β = 1.386, P < 0.001), alanine aminotransferase (β = 0.064, P = 0.029), and total bilirubin (β = -0.881, P = 0.009). In multiple logistic regression analysis, increased CAP was independently associated with increased metabolic syndrome risk (per 10 dB/m increase; odds ratio, 1.093; 95% confidence interval, 1.009-1.183; P = 0.029) even after adjusting for multiple confounding factors. Conclusion: Increased CAP measured with transient elastography significantly correlated with and could predict increased metabolic syndrome risk in chronic kidney disease patients.

Original languageEnglish
Pages (from-to)48-57
Number of pages10
JournalKidney Research and Clinical Practice
Issue number1
Publication statusPublished - 2017 Mar

Bibliographical note

Funding Information:
We thank the Institute of Gastroenterology, Yonsei University College of Medicine for providing data about transient elastography. This work was supported by the Brain Korea 21 Project for Medical Science, Yonsei University, by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2014–050098), and by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (H14C2003).

Publisher Copyright:
© 2017 by The Korean Society of Nephrology.

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology


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