Favorable long-term outcome after drug-eluting stent implantation in nonbifurcation lesions that involve unprotected left main coronary artery: A multicenter registry

Alaide Chieffo, Seung J. Park, Marco Valgimigli, Young H. Kim, Joost Daemen, Imad Sheiban, Alessandra Truffa, Matteo Montorfano, Flavio Airoldi, Giuseppe Sangiorgi, Mauro Carlino, Iassen Michev, Cheol W. Lee, Myeong K. Hong, Seong W. Park, Claudio Moretti, Erminio Bonizzoni, Renata Rogacka, Patrick W. Serruys, Antonio Colombo

Research output: Contribution to journalArticle

177 Citations (Scopus)

Abstract

BACKGROUND - The presence of a lumen narrowing at the ostium and the body of an unprotected left main coronary artery but does not require bifurcation treatment is a class I indication of surgical revascularization. METHODS AND RESULTS - A total of 147 consecutive patients who had a stenosis in the ostium and/or the midshaft of an unprotected left main coronary artery (treatment of the bifurcation not required) and were electively treated with percutaneous coronary intervention and sirolimus-eluting stents (n=107) or paclitaxel-eluting stents (n=40) in 5 centres were included in this registry. In 72 patients (almost 50%), intravascular ultrasound guidance was performed. Procedural success was achieved in 99% of the patients; in 1 patient with stenosis in the left main coronary artery ostium, a >30% residual stenosis persisted at the end of the procedure, and the patient was referred for coronary artery bypass graft surgery. During hospitalization, no patients experienced a Q-wave myocardial infarction or died. One patient died 19 days after the procedure because of pulmonary infection. At long-term clinical follow-up (886±308 days), 5 patients had died; 7 patients had target vessel revascularization (5 repeat percutaneous coronary interventions and 2 coronary artery bypass graft surgeries), and of these only 1 patient had a target lesion revascularization. Angiographic follow-up was performed in 106 patients (72%) with a late loss of -0.01 mm. Restenosis in the left main trunk occurred only in 1 patient (0.9%). CONCLUSIONS - Percutaneous coronary intervention with sirolimus-eluting stents or paclitaxel-eluting stents implantation in nonbifurcation left main coronary artery lesions appears safe with a long-term major adverse clinical event rate of 7.4% and a restenosis rate of 0.9%.

Original languageEnglish
Pages (from-to)158-162
Number of pages5
JournalCirculation
Volume116
Issue number2
DOIs
Publication statusPublished - 2007 Jul 1

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Favorable long-term outcome after drug-eluting stent implantation in nonbifurcation lesions that involve unprotected left main coronary artery: A multicenter registry'. Together they form a unique fingerprint.

  • Cite this

    Chieffo, A., Park, S. J., Valgimigli, M., Kim, Y. H., Daemen, J., Sheiban, I., Truffa, A., Montorfano, M., Airoldi, F., Sangiorgi, G., Carlino, M., Michev, I., Lee, C. W., Hong, M. K., Park, S. W., Moretti, C., Bonizzoni, E., Rogacka, R., Serruys, P. W., & Colombo, A. (2007). Favorable long-term outcome after drug-eluting stent implantation in nonbifurcation lesions that involve unprotected left main coronary artery: A multicenter registry. Circulation, 116(2), 158-162. https://doi.org/10.1161/CIRCULATIONAHA.107.692178