Feasibility of single scan for simultaneous evaluation of regional krypton and iodine concentrations with dual-energy CT: An experimental study

Sae Rom Hong, Suyon Chang, Dong Jin Im, Young Joo Suh, Yoo Jin Hong, Jin Hur, Young Jin Kim, Byoung Wook Choi, Hye Jeong Lee

Research output: Contribution to journalArticle

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Abstract

Purpose: To evaluate the feasibility of a simultaneous single scan of regional krypton and iodine concentrations by using dualenergy computed tomography (CT). Materials and Methods: The study was approved by the institutional animal experimental committee. An airway obstruction model was first made in 10 beagle dogs, and a pulmonary arterial occlusion was induced in each animal after 1 week. For each model, three sessions of dual-energy CT (80% krypton ventilation [krypton CT], 80% krypton ventilation with iodine enhancement [mixed-contrast agent CT], and iodine enhancement [iodine CT]) were performed. Krypton maps were made from krypton and mixed-contrast agent CT, and iodine maps were made from iodine and mixed- contrast agent CT. Observers measured overlay Hounsfield units of the diseased and contralateral segments on each map. Values were compared by using the Wilcoxon signed-rank test. Results: In krypton maps of airway obstruction, overlay Hounsfield units of diseased segments were significantly decreased compared with those of contralateral segments in both krypton and mixed-contrast agent CT (P = .005 for both). However, the values of mixed-contrast agent CT were significantly higher than those of krypton CT for both segments (P = .005 and .007, respectively). In iodine maps of pulmonary arterial occlusion, values were significantly lower in diseased segments than in contralateral segments for both iodine and mixed-contrast agent CT (P = .005 for both), without significant difference between iodine and mixed-contrast agent CT for both segments (P = .126 and .307, respectively). Conclusion: Although some limitations may exist, it might be feasible to analyze regional krypton and iodine concentrations simultaneously by using dual-energy CT.

Original languageEnglish
Pages (from-to)597-605
Number of pages9
JournalRadiology
Volume281
Issue number2
DOIs
Publication statusPublished - 2016 Jan 1

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Krypton
Iodine
Tomography
Contrast Media
Airway Obstruction
Ventilation
Lung
Nonparametric Statistics

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Hong, Sae Rom ; Chang, Suyon ; Im, Dong Jin ; Suh, Young Joo ; Hong, Yoo Jin ; Hur, Jin ; Kim, Young Jin ; Choi, Byoung Wook ; Lee, Hye Jeong. / Feasibility of single scan for simultaneous evaluation of regional krypton and iodine concentrations with dual-energy CT : An experimental study. In: Radiology. 2016 ; Vol. 281, No. 2. pp. 597-605.
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abstract = "Purpose: To evaluate the feasibility of a simultaneous single scan of regional krypton and iodine concentrations by using dualenergy computed tomography (CT). Materials and Methods: The study was approved by the institutional animal experimental committee. An airway obstruction model was first made in 10 beagle dogs, and a pulmonary arterial occlusion was induced in each animal after 1 week. For each model, three sessions of dual-energy CT (80{\%} krypton ventilation [krypton CT], 80{\%} krypton ventilation with iodine enhancement [mixed-contrast agent CT], and iodine enhancement [iodine CT]) were performed. Krypton maps were made from krypton and mixed-contrast agent CT, and iodine maps were made from iodine and mixed- contrast agent CT. Observers measured overlay Hounsfield units of the diseased and contralateral segments on each map. Values were compared by using the Wilcoxon signed-rank test. Results: In krypton maps of airway obstruction, overlay Hounsfield units of diseased segments were significantly decreased compared with those of contralateral segments in both krypton and mixed-contrast agent CT (P = .005 for both). However, the values of mixed-contrast agent CT were significantly higher than those of krypton CT for both segments (P = .005 and .007, respectively). In iodine maps of pulmonary arterial occlusion, values were significantly lower in diseased segments than in contralateral segments for both iodine and mixed-contrast agent CT (P = .005 for both), without significant difference between iodine and mixed-contrast agent CT for both segments (P = .126 and .307, respectively). Conclusion: Although some limitations may exist, it might be feasible to analyze regional krypton and iodine concentrations simultaneously by using dual-energy CT.",
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Feasibility of single scan for simultaneous evaluation of regional krypton and iodine concentrations with dual-energy CT : An experimental study. / Hong, Sae Rom; Chang, Suyon; Im, Dong Jin; Suh, Young Joo; Hong, Yoo Jin; Hur, Jin; Kim, Young Jin; Choi, Byoung Wook; Lee, Hye Jeong.

In: Radiology, Vol. 281, No. 2, 01.01.2016, p. 597-605.

Research output: Contribution to journalArticle

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N2 - Purpose: To evaluate the feasibility of a simultaneous single scan of regional krypton and iodine concentrations by using dualenergy computed tomography (CT). Materials and Methods: The study was approved by the institutional animal experimental committee. An airway obstruction model was first made in 10 beagle dogs, and a pulmonary arterial occlusion was induced in each animal after 1 week. For each model, three sessions of dual-energy CT (80% krypton ventilation [krypton CT], 80% krypton ventilation with iodine enhancement [mixed-contrast agent CT], and iodine enhancement [iodine CT]) were performed. Krypton maps were made from krypton and mixed-contrast agent CT, and iodine maps were made from iodine and mixed- contrast agent CT. Observers measured overlay Hounsfield units of the diseased and contralateral segments on each map. Values were compared by using the Wilcoxon signed-rank test. Results: In krypton maps of airway obstruction, overlay Hounsfield units of diseased segments were significantly decreased compared with those of contralateral segments in both krypton and mixed-contrast agent CT (P = .005 for both). However, the values of mixed-contrast agent CT were significantly higher than those of krypton CT for both segments (P = .005 and .007, respectively). In iodine maps of pulmonary arterial occlusion, values were significantly lower in diseased segments than in contralateral segments for both iodine and mixed-contrast agent CT (P = .005 for both), without significant difference between iodine and mixed-contrast agent CT for both segments (P = .126 and .307, respectively). Conclusion: Although some limitations may exist, it might be feasible to analyze regional krypton and iodine concentrations simultaneously by using dual-energy CT.

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