Feasibility of three-dimensional macroporous scaffold using calcium phosphate glass and polyurethane sponge

Young Sang Park, Kyoung Nam Kim, Kwangmahn Kim, Seongho Choi, Chong Kwan Kim, Racquel Z. Legeros, Yong Keun Lee

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Tissue engineering presents an alternative approach to the repair of a damaged tissue by avoiding the need for a permanent implant made of an engineered artificial material. A suitable temporary scaffold material that exhibits adequate mechanical and biological properties is required to enable tissue regeneration by exploiting the body's inherent repair mechanism, i.e. a regenerative allograft. Synthetic bioresorbable polymers have been attracting attention as tissue engineering scaffolds. However, a number of problems have been encountered such as inflammatory responses and lack of bioactivity. Another good candidate for a tissue engineering scaffold is the calcium phosphates because of their good biocompatibility and osteointegrative properties. Their slow biodegradation is still remains problem, especially for the filling of large bony defects. In this study, we investigated the fabrication method of a three-dimensional reticulated scaffold with interconnected pores of several hundred micrometers using calcium phosphate glass in the system of CaO-CaF 2-P2O5-MgO-ZnO and a polyurethane sponge as a template. Calcium phosphate glass slurry was homogenously thick coated when the weight percentage of the calcium phosphate glass powder was 40% with 8 wt% of polyvinyl alcohol as a binder. Addition of 10 wt% dimethyl formamide as a drying control chemical additive into a slurry almost prevented the crack formation during drying. Sintering of the dried porous block at 850°C exhibited the densest microstructure as well as the entire elimination of the organic additives. Repeating the process significantly increased compressive strength of sintered porous body due to the thickening of the struts. To summarize, macroporous calcium phosphate glass can be fabricated with 500≈800 μm of pore size and a three-dimensionally interconnected open pore system. It is thought that this kind of biodegradable glass scaffold combined with osteogenic cells has potential to be studied further as a tissue-engineered bone substitute.

Original languageEnglish
Pages (from-to)4357-4364
Number of pages8
JournalJournal of Materials Science
Volume41
Issue number13
DOIs
Publication statusPublished - 2006 Jul 1

Fingerprint

Polyurethanes
Calcium phosphate
Scaffolds (biology)
Glass
Tissue engineering
Scaffolds
Tissue Scaffolds
phosphorus pentoxide
Drying
Repair
Calcium Phosphates
Tissue
Bone Substitutes
Polyvinyl Alcohol
Tissue regeneration
Struts
Polyvinyl alcohols
Dimethylformamide
Biodegradation
Bioactivity

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Park, Young Sang ; Kim, Kyoung Nam ; Kim, Kwangmahn ; Choi, Seongho ; Kim, Chong Kwan ; Legeros, Racquel Z. ; Lee, Yong Keun. / Feasibility of three-dimensional macroporous scaffold using calcium phosphate glass and polyurethane sponge. In: Journal of Materials Science. 2006 ; Vol. 41, No. 13. pp. 4357-4364.
@article{7737d2aecc934b8e992cbfcbe4c8d031,
title = "Feasibility of three-dimensional macroporous scaffold using calcium phosphate glass and polyurethane sponge",
abstract = "Tissue engineering presents an alternative approach to the repair of a damaged tissue by avoiding the need for a permanent implant made of an engineered artificial material. A suitable temporary scaffold material that exhibits adequate mechanical and biological properties is required to enable tissue regeneration by exploiting the body's inherent repair mechanism, i.e. a regenerative allograft. Synthetic bioresorbable polymers have been attracting attention as tissue engineering scaffolds. However, a number of problems have been encountered such as inflammatory responses and lack of bioactivity. Another good candidate for a tissue engineering scaffold is the calcium phosphates because of their good biocompatibility and osteointegrative properties. Their slow biodegradation is still remains problem, especially for the filling of large bony defects. In this study, we investigated the fabrication method of a three-dimensional reticulated scaffold with interconnected pores of several hundred micrometers using calcium phosphate glass in the system of CaO-CaF 2-P2O5-MgO-ZnO and a polyurethane sponge as a template. Calcium phosphate glass slurry was homogenously thick coated when the weight percentage of the calcium phosphate glass powder was 40{\%} with 8 wt{\%} of polyvinyl alcohol as a binder. Addition of 10 wt{\%} dimethyl formamide as a drying control chemical additive into a slurry almost prevented the crack formation during drying. Sintering of the dried porous block at 850°C exhibited the densest microstructure as well as the entire elimination of the organic additives. Repeating the process significantly increased compressive strength of sintered porous body due to the thickening of the struts. To summarize, macroporous calcium phosphate glass can be fabricated with 500≈800 μm of pore size and a three-dimensionally interconnected open pore system. It is thought that this kind of biodegradable glass scaffold combined with osteogenic cells has potential to be studied further as a tissue-engineered bone substitute.",
author = "Park, {Young Sang} and Kim, {Kyoung Nam} and Kwangmahn Kim and Seongho Choi and Kim, {Chong Kwan} and Legeros, {Racquel Z.} and Lee, {Yong Keun}",
year = "2006",
month = "7",
day = "1",
doi = "10.1007/s10853-006-6261-0",
language = "English",
volume = "41",
pages = "4357--4364",
journal = "Journal of Materials Science",
issn = "0022-2461",
publisher = "Springer Netherlands",
number = "13",

}

Feasibility of three-dimensional macroporous scaffold using calcium phosphate glass and polyurethane sponge. / Park, Young Sang; Kim, Kyoung Nam; Kim, Kwangmahn; Choi, Seongho; Kim, Chong Kwan; Legeros, Racquel Z.; Lee, Yong Keun.

In: Journal of Materials Science, Vol. 41, No. 13, 01.07.2006, p. 4357-4364.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Feasibility of three-dimensional macroporous scaffold using calcium phosphate glass and polyurethane sponge

AU - Park, Young Sang

AU - Kim, Kyoung Nam

AU - Kim, Kwangmahn

AU - Choi, Seongho

AU - Kim, Chong Kwan

AU - Legeros, Racquel Z.

AU - Lee, Yong Keun

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Tissue engineering presents an alternative approach to the repair of a damaged tissue by avoiding the need for a permanent implant made of an engineered artificial material. A suitable temporary scaffold material that exhibits adequate mechanical and biological properties is required to enable tissue regeneration by exploiting the body's inherent repair mechanism, i.e. a regenerative allograft. Synthetic bioresorbable polymers have been attracting attention as tissue engineering scaffolds. However, a number of problems have been encountered such as inflammatory responses and lack of bioactivity. Another good candidate for a tissue engineering scaffold is the calcium phosphates because of their good biocompatibility and osteointegrative properties. Their slow biodegradation is still remains problem, especially for the filling of large bony defects. In this study, we investigated the fabrication method of a three-dimensional reticulated scaffold with interconnected pores of several hundred micrometers using calcium phosphate glass in the system of CaO-CaF 2-P2O5-MgO-ZnO and a polyurethane sponge as a template. Calcium phosphate glass slurry was homogenously thick coated when the weight percentage of the calcium phosphate glass powder was 40% with 8 wt% of polyvinyl alcohol as a binder. Addition of 10 wt% dimethyl formamide as a drying control chemical additive into a slurry almost prevented the crack formation during drying. Sintering of the dried porous block at 850°C exhibited the densest microstructure as well as the entire elimination of the organic additives. Repeating the process significantly increased compressive strength of sintered porous body due to the thickening of the struts. To summarize, macroporous calcium phosphate glass can be fabricated with 500≈800 μm of pore size and a three-dimensionally interconnected open pore system. It is thought that this kind of biodegradable glass scaffold combined with osteogenic cells has potential to be studied further as a tissue-engineered bone substitute.

AB - Tissue engineering presents an alternative approach to the repair of a damaged tissue by avoiding the need for a permanent implant made of an engineered artificial material. A suitable temporary scaffold material that exhibits adequate mechanical and biological properties is required to enable tissue regeneration by exploiting the body's inherent repair mechanism, i.e. a regenerative allograft. Synthetic bioresorbable polymers have been attracting attention as tissue engineering scaffolds. However, a number of problems have been encountered such as inflammatory responses and lack of bioactivity. Another good candidate for a tissue engineering scaffold is the calcium phosphates because of their good biocompatibility and osteointegrative properties. Their slow biodegradation is still remains problem, especially for the filling of large bony defects. In this study, we investigated the fabrication method of a three-dimensional reticulated scaffold with interconnected pores of several hundred micrometers using calcium phosphate glass in the system of CaO-CaF 2-P2O5-MgO-ZnO and a polyurethane sponge as a template. Calcium phosphate glass slurry was homogenously thick coated when the weight percentage of the calcium phosphate glass powder was 40% with 8 wt% of polyvinyl alcohol as a binder. Addition of 10 wt% dimethyl formamide as a drying control chemical additive into a slurry almost prevented the crack formation during drying. Sintering of the dried porous block at 850°C exhibited the densest microstructure as well as the entire elimination of the organic additives. Repeating the process significantly increased compressive strength of sintered porous body due to the thickening of the struts. To summarize, macroporous calcium phosphate glass can be fabricated with 500≈800 μm of pore size and a three-dimensionally interconnected open pore system. It is thought that this kind of biodegradable glass scaffold combined with osteogenic cells has potential to be studied further as a tissue-engineered bone substitute.

UR - http://www.scopus.com/inward/record.url?scp=33747060811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747060811&partnerID=8YFLogxK

U2 - 10.1007/s10853-006-6261-0

DO - 10.1007/s10853-006-6261-0

M3 - Article

VL - 41

SP - 4357

EP - 4364

JO - Journal of Materials Science

JF - Journal of Materials Science

SN - 0022-2461

IS - 13

ER -