Feasibility of using distal endpoints for In-room PET Range Verification of Proton Therapy

K. Grogg, X. Zhu, Chulhee Min, B. Winey, T. Bortfeld, H. Paganetti, H. Shih, G. El Fakhri

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In an effort to verify the dose delivery in proton therapy, Positron Emission Tomography (PET) scans have been employed to measure the distribution of β+ radioactivity produced from nuclear reactions of the protons with native nuclei. Because the dose and PET distributions are not directly comparable, the range verification is currently carried out by comparing measured and Monte Carlo (MC) simulation predicted PET distributions. In order to reduce the reliance on MC, MC-PET and dose distal endpoints were compared to explore the feasibility of using distal endpoints for in-room PET range verification. MC simulations were generated for six head and neck patients with corrections for radiological decay, biological washout, and PET resolution. One-dimensional profiles of the dose and MC-PET were examined along the direction of the beam and covering the cross section of the beam. The chosen endpoints of the MC-PET (y-intercept of the linear fit to the distal falloff) and MC dose (20-50% of maximum dose) correspond to where most of the protons are below the threshold energy for the nuclear reactions. The difference in endpoint range between the distal surfaces of the dose and MC-PET are compared and the spread of range differences are assessed. Among the six patients, the mean difference between MC-PET and dose depth was found to be -1.5 mm to +3.7 mm between patients, with a standard deviation of 1.3 to 6 mm across the individual beams.

Original languageEnglish
Title of host publication2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012
Pages3890-3894
Number of pages5
DOIs
Publication statusPublished - 2012 Dec 1
Event2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012 - Anaheim, CA, United States
Duration: 2012 Oct 292012 Nov 3

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Other

Other2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012
CountryUnited States
CityAnaheim, CA
Period12/10/2912/11/3

Fingerprint

Proton Therapy
Positron-Emission Tomography
rooms
therapy
positrons
tomography
protons
dosage
nuclear reactions
Protons
Nuclear Energy
fallout
radioactivity
Radioactivity
standard deviation
delivery
coverings
Neck
simulation
Head

All Science Journal Classification (ASJC) codes

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Grogg, K., Zhu, X., Min, C., Winey, B., Bortfeld, T., Paganetti, H., ... El Fakhri, G. (2012). Feasibility of using distal endpoints for In-room PET Range Verification of Proton Therapy. In 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012 (pp. 3890-3894). [6551892] (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2012.6551892
Grogg, K. ; Zhu, X. ; Min, Chulhee ; Winey, B. ; Bortfeld, T. ; Paganetti, H. ; Shih, H. ; El Fakhri, G. / Feasibility of using distal endpoints for In-room PET Range Verification of Proton Therapy. 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012. 2012. pp. 3890-3894 (IEEE Nuclear Science Symposium Conference Record).
@inproceedings{1b68f5df452949aaa17a66ba8a1d5b32,
title = "Feasibility of using distal endpoints for In-room PET Range Verification of Proton Therapy",
abstract = "In an effort to verify the dose delivery in proton therapy, Positron Emission Tomography (PET) scans have been employed to measure the distribution of β+ radioactivity produced from nuclear reactions of the protons with native nuclei. Because the dose and PET distributions are not directly comparable, the range verification is currently carried out by comparing measured and Monte Carlo (MC) simulation predicted PET distributions. In order to reduce the reliance on MC, MC-PET and dose distal endpoints were compared to explore the feasibility of using distal endpoints for in-room PET range verification. MC simulations were generated for six head and neck patients with corrections for radiological decay, biological washout, and PET resolution. One-dimensional profiles of the dose and MC-PET were examined along the direction of the beam and covering the cross section of the beam. The chosen endpoints of the MC-PET (y-intercept of the linear fit to the distal falloff) and MC dose (20-50{\%} of maximum dose) correspond to where most of the protons are below the threshold energy for the nuclear reactions. The difference in endpoint range between the distal surfaces of the dose and MC-PET are compared and the spread of range differences are assessed. Among the six patients, the mean difference between MC-PET and dose depth was found to be -1.5 mm to +3.7 mm between patients, with a standard deviation of 1.3 to 6 mm across the individual beams.",
author = "K. Grogg and X. Zhu and Chulhee Min and B. Winey and T. Bortfeld and H. Paganetti and H. Shih and {El Fakhri}, G.",
year = "2012",
month = "12",
day = "1",
doi = "10.1109/NSSMIC.2012.6551892",
language = "English",
isbn = "9781467320306",
series = "IEEE Nuclear Science Symposium Conference Record",
pages = "3890--3894",
booktitle = "2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012",

}

Grogg, K, Zhu, X, Min, C, Winey, B, Bortfeld, T, Paganetti, H, Shih, H & El Fakhri, G 2012, Feasibility of using distal endpoints for In-room PET Range Verification of Proton Therapy. in 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012., 6551892, IEEE Nuclear Science Symposium Conference Record, pp. 3890-3894, 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012, Anaheim, CA, United States, 12/10/29. https://doi.org/10.1109/NSSMIC.2012.6551892

Feasibility of using distal endpoints for In-room PET Range Verification of Proton Therapy. / Grogg, K.; Zhu, X.; Min, Chulhee; Winey, B.; Bortfeld, T.; Paganetti, H.; Shih, H.; El Fakhri, G.

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012. 2012. p. 3890-3894 6551892 (IEEE Nuclear Science Symposium Conference Record).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Feasibility of using distal endpoints for In-room PET Range Verification of Proton Therapy

AU - Grogg, K.

AU - Zhu, X.

AU - Min, Chulhee

AU - Winey, B.

AU - Bortfeld, T.

AU - Paganetti, H.

AU - Shih, H.

AU - El Fakhri, G.

PY - 2012/12/1

Y1 - 2012/12/1

N2 - In an effort to verify the dose delivery in proton therapy, Positron Emission Tomography (PET) scans have been employed to measure the distribution of β+ radioactivity produced from nuclear reactions of the protons with native nuclei. Because the dose and PET distributions are not directly comparable, the range verification is currently carried out by comparing measured and Monte Carlo (MC) simulation predicted PET distributions. In order to reduce the reliance on MC, MC-PET and dose distal endpoints were compared to explore the feasibility of using distal endpoints for in-room PET range verification. MC simulations were generated for six head and neck patients with corrections for radiological decay, biological washout, and PET resolution. One-dimensional profiles of the dose and MC-PET were examined along the direction of the beam and covering the cross section of the beam. The chosen endpoints of the MC-PET (y-intercept of the linear fit to the distal falloff) and MC dose (20-50% of maximum dose) correspond to where most of the protons are below the threshold energy for the nuclear reactions. The difference in endpoint range between the distal surfaces of the dose and MC-PET are compared and the spread of range differences are assessed. Among the six patients, the mean difference between MC-PET and dose depth was found to be -1.5 mm to +3.7 mm between patients, with a standard deviation of 1.3 to 6 mm across the individual beams.

AB - In an effort to verify the dose delivery in proton therapy, Positron Emission Tomography (PET) scans have been employed to measure the distribution of β+ radioactivity produced from nuclear reactions of the protons with native nuclei. Because the dose and PET distributions are not directly comparable, the range verification is currently carried out by comparing measured and Monte Carlo (MC) simulation predicted PET distributions. In order to reduce the reliance on MC, MC-PET and dose distal endpoints were compared to explore the feasibility of using distal endpoints for in-room PET range verification. MC simulations were generated for six head and neck patients with corrections for radiological decay, biological washout, and PET resolution. One-dimensional profiles of the dose and MC-PET were examined along the direction of the beam and covering the cross section of the beam. The chosen endpoints of the MC-PET (y-intercept of the linear fit to the distal falloff) and MC dose (20-50% of maximum dose) correspond to where most of the protons are below the threshold energy for the nuclear reactions. The difference in endpoint range between the distal surfaces of the dose and MC-PET are compared and the spread of range differences are assessed. Among the six patients, the mean difference between MC-PET and dose depth was found to be -1.5 mm to +3.7 mm between patients, with a standard deviation of 1.3 to 6 mm across the individual beams.

UR - http://www.scopus.com/inward/record.url?scp=84881603256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881603256&partnerID=8YFLogxK

U2 - 10.1109/NSSMIC.2012.6551892

DO - 10.1109/NSSMIC.2012.6551892

M3 - Conference contribution

AN - SCOPUS:84881603256

SN - 9781467320306

T3 - IEEE Nuclear Science Symposium Conference Record

SP - 3890

EP - 3894

BT - 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012

ER -

Grogg K, Zhu X, Min C, Winey B, Bortfeld T, Paganetti H et al. Feasibility of using distal endpoints for In-room PET Range Verification of Proton Therapy. In 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012. 2012. p. 3890-3894. 6551892. (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2012.6551892