Fecal Microbiota Transplantation for multidrug-resistant organism: Efficacy and Response prediction

Hye Seong, Sang Kil Lee, Jae Hee Cheon, Dong Eun Yong, Hong Koh, Yun Koo Kang, Woo Young Jeong, Woon Ji Lee, Yujin Sohn, Yunsuk Cho, Jong Hoon Hyun, Yae Jee Baek, Moo Hyun Kim, Jung Ho Kim, Jin Young Ahn, Nam Su Ku, Su Jin Jeong, Joon Sup Yeom, Min Seok Cho, Je Hee LeeByung Yong Kim, Jun Yong Choi

Research output: Contribution to journalArticle

Abstract

Objectives: The increasing prevalence of multidrug-resistant microorganisms (MDRO) is increasing the frequency of poor clinical outcomes, prolonging hospitalizations, and raising healthcare costs. This study evaluated the eradication efficacy of fecal microbiota transplantation (FMT) and identified microbial and functional biomarkers of MDRO decolonization. Methods: Fecal solution obtained from healthy unrelated donors was infused in the participants’ guts which had been colonized with carbapenemase-producing enterobacteriacea (CPE), vancomycin-resistant enterococci (VRE), or both CPE and VRE. Fecal samples from recipients were collected and microbiome changes before and after FMT were assessed. Results: Twenty-four (68.6%) out of 35 patients were decolonized within one year of receiving FMT. Multivariate analysis showed that FMT (FMT: hazard ratio (HR) = 5.343, 95% confidence interval (CI) = 1.877-15.212, p = 0.002) and MDRO types (CPE: HR = 11.146, 95% CI = 2.420-51.340, p = 0.002; CPE/VRE: HR = 2.948, 95% CI = 1.200-7.246, p = 0.018; VRE served as the reference) were significant independent factors associated with time to decolonization. Microbiota analysis showed higher richness and biodiversity before FMT resulted in VRE decolonization. The species Clostridium ramosum and the genuses Anaerostipes and Eisenbergiella could serve as taxonomic biomarkers and K02017 could serve as a functional biomarker for VRE clearance. Conclusion: FMT is an effective way to decolonize MDRO and its effectiveness may be predicted by microbiome analysis.

Original languageEnglish
Article number4834
JournalJournal of Infection
DOIs
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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    Seong, H., Lee, S. K., Cheon, J. H., Yong, D. E., Koh, H., Kang, Y. K., Jeong, W. Y., Lee, W. J., Sohn, Y., Cho, Y., Hyun, J. H., Baek, Y. J., Kim, M. H., Kim, J. H., Ahn, J. Y., Ku, N. S., Jeong, S. J., Yeom, J. S., Cho, M. S., ... Choi, J. Y. (Accepted/In press). Fecal Microbiota Transplantation for multidrug-resistant organism: Efficacy and Response prediction. Journal of Infection, [4834]. https://doi.org/10.1016/j.jinf.2020.09.003