Fiber probe based microfluidic raman spectroscopy

P. C. Ashok, G. P. Singh, K. M. Tan, K. Dholakia

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

We report a novel fiber probe based Raman detection system on a microfluidic platform where a split Raman probe is directly embedded into a polydimethylsiloxane (PDMS) chip. In contrast to previous Raman detection schemes in microfluidics, probe based detection offers reduced background and portability. Compared to conventional backscattering probe designs, the split fiber probe we used in this system, results in a reduced size and offers flexibility to modify the collection geometry to minimize the background generated by the fibers. Also our microfluidic chip design enables us to obtain an alignment free system. As a proof of concept we demonstrate the sensitivity of the device for urea detection at relevant human physiological levels with a low acquisition time. The development of this system on a microfluidic platform means portable, lab on a chip devices for biological analyte detection and environmental sensing using Raman spectroscopy are now within reach.

Original languageEnglish
Pages (from-to)7642-7649
Number of pages8
JournalOptics Express
Volume18
Issue number8
DOIs
Publication statusPublished - 2010 Apr 12

Fingerprint

Raman spectroscopy
fibers
probes
platforms
chips
lab-on-a-chip devices
ureas
acquisition
backscattering
flexibility
alignment
sensitivity
geometry

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics

Cite this

Ashok, P. C. ; Singh, G. P. ; Tan, K. M. ; Dholakia, K. / Fiber probe based microfluidic raman spectroscopy. In: Optics Express. 2010 ; Vol. 18, No. 8. pp. 7642-7649.
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Fiber probe based microfluidic raman spectroscopy. / Ashok, P. C.; Singh, G. P.; Tan, K. M.; Dholakia, K.

In: Optics Express, Vol. 18, No. 8, 12.04.2010, p. 7642-7649.

Research output: Contribution to journalArticle

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