Field-matter integral overlap to estimate the sensitivity of surface plasmon resonance biosensors

Wonju Lee, Donghyun Kim

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We have analyzed the effectiveness of field-matter integral overlap between target index distribution and local near-fields to assess detection sensitivity of surface plasmon resonance (SPR) biosensors. The correlation of the overlap with sensitivity was clear. An overlap integral defined with lateral electric field intensity produced the highest correlation due to tangential continuity across a boundary. Among the three detection scenarios considered, the correlation for localized SPR sensing was slightly lower than that of thin film-based detection and improved with an increased fill factor in the structure. The results will be useful to maximize the optical signature created by target interactions and to produce highest sensitivity of SPR detection to variations when target or field distribution is not uniform.

Original languageEnglish
Pages (from-to)1367-1376
Number of pages10
JournalJournal of the Optical Society of America A: Optics and Image Science, and Vision
Volume29
Issue number7
DOIs
Publication statusPublished - 2012 Jul 1

Fingerprint

Surface plasmon resonance
bioinstrumentation
surface plasmon resonance
Biosensors
estimates
Electric fields
sensitivity
Thin films
continuity
near fields
signatures
electric fields
thin films
interactions

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Computer Vision and Pattern Recognition

Cite this

@article{f3ca2ca4aeb14fcb9d90ab057a916bfa,
title = "Field-matter integral overlap to estimate the sensitivity of surface plasmon resonance biosensors",
abstract = "We have analyzed the effectiveness of field-matter integral overlap between target index distribution and local near-fields to assess detection sensitivity of surface plasmon resonance (SPR) biosensors. The correlation of the overlap with sensitivity was clear. An overlap integral defined with lateral electric field intensity produced the highest correlation due to tangential continuity across a boundary. Among the three detection scenarios considered, the correlation for localized SPR sensing was slightly lower than that of thin film-based detection and improved with an increased fill factor in the structure. The results will be useful to maximize the optical signature created by target interactions and to produce highest sensitivity of SPR detection to variations when target or field distribution is not uniform.",
author = "Wonju Lee and Donghyun Kim",
year = "2012",
month = "7",
day = "1",
doi = "10.1364/JOSAA.29.001367",
language = "English",
volume = "29",
pages = "1367--1376",
journal = "Journal of the Optical Society of America A: Optics and Image Science, and Vision",
issn = "1084-7529",
publisher = "The Optical Society",
number = "7",

}

TY - JOUR

T1 - Field-matter integral overlap to estimate the sensitivity of surface plasmon resonance biosensors

AU - Lee, Wonju

AU - Kim, Donghyun

PY - 2012/7/1

Y1 - 2012/7/1

N2 - We have analyzed the effectiveness of field-matter integral overlap between target index distribution and local near-fields to assess detection sensitivity of surface plasmon resonance (SPR) biosensors. The correlation of the overlap with sensitivity was clear. An overlap integral defined with lateral electric field intensity produced the highest correlation due to tangential continuity across a boundary. Among the three detection scenarios considered, the correlation for localized SPR sensing was slightly lower than that of thin film-based detection and improved with an increased fill factor in the structure. The results will be useful to maximize the optical signature created by target interactions and to produce highest sensitivity of SPR detection to variations when target or field distribution is not uniform.

AB - We have analyzed the effectiveness of field-matter integral overlap between target index distribution and local near-fields to assess detection sensitivity of surface plasmon resonance (SPR) biosensors. The correlation of the overlap with sensitivity was clear. An overlap integral defined with lateral electric field intensity produced the highest correlation due to tangential continuity across a boundary. Among the three detection scenarios considered, the correlation for localized SPR sensing was slightly lower than that of thin film-based detection and improved with an increased fill factor in the structure. The results will be useful to maximize the optical signature created by target interactions and to produce highest sensitivity of SPR detection to variations when target or field distribution is not uniform.

UR - http://www.scopus.com/inward/record.url?scp=84863751723&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863751723&partnerID=8YFLogxK

U2 - 10.1364/JOSAA.29.001367

DO - 10.1364/JOSAA.29.001367

M3 - Article

VL - 29

SP - 1367

EP - 1376

JO - Journal of the Optical Society of America A: Optics and Image Science, and Vision

JF - Journal of the Optical Society of America A: Optics and Image Science, and Vision

SN - 1084-7529

IS - 7

ER -