Filbertone ameliorates adiposity in mice fed a high-fat diet via activation of cAMP signaling

Youna Moon, Tao Tong, Wesuk Kang, Taesun Park

Research output: Contribution to journalArticlepeer-review


The aim of this research was to estimate the preventive effects of filbertone, the main flavor compound in hazelnuts, on lipid accumulation in the adipose tissue of mice fed a high-fat diet (HFD) and to reveal the underlying molecular mechanisms. Male C57BL/6N mice were fed chow, a HFD, or a 0.025% filbertone-supplemented HFD for 14 weeks. We found that filbertone supplementation resulted in significant reductions in body weight gain and lipid accumulation in adipose tissue, with parallel improvements in plasma lipid levels (triglycerides, total cholesterol, and free fatty acids) and proinflammatory cytokines (interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α)). Molecular analysis revealed that filbertone treatment led to reprogramming of metabolic signatures in the cyclic adenosine monophosphate (cAMP) pathway. Filbertone supplementation significantly increased the cAMP level and increased downstream protein kinase A catalytic subunit (PKA) signaling in mouse adipose tissue. The mRNA level of adipogenesis-related genes was downregulated in the adipose tissue of filbertone-fed mice compared to control mice fed the HFD alone. Furthermore, filbertone treatment elevated the expression of thermogenic genes in mouse adipose tissue. Filbertone reduced intracellular lipid accumulation and increased the oxygen consumption rate in 3T3-L1 cells and these filbertone-induced changes were abrogated by the adenylate cyclases (ADCY) inhibitor. Taken together, our results suggest that the beneficial effects of filbertone on lipid accumulation may be associated with the activation of cAMP signaling.

Original languageEnglish
Article number1749
Issue number8
Publication statusPublished - 2019 Aug

Bibliographical note

Funding Information:
Funding: The project described was funded by the MOTIE (Ministry of Trade, Industry, and Energy), Republic of Korea, under the Support Project and R&D Company (SPARC) (grant no. N0002416) supervised by the KIAT (Korea Institute for Advancement of Technology).

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Filbertone ameliorates adiposity in mice fed a high-fat diet via activation of cAMP signaling'. Together they form a unique fingerprint.

Cite this