Findings from frozen sections of spinal subependymomas: Is it possible to differentiate this diagnosis from other common spinal tumors?

Seung Kyu Choi, Sang Hoon Lee, Byeongwoo Kim, Yang Ki Minn, Keung Nyun Kim, Se Hoon Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Subependymomas are slow-growing, benign neoplasms that are rarely found in the spinal cord. Because of the differences in the treatment plans, it might be very helpful for neurosurgeons to intraoperatively establish a diagnosis of spinal subependymoma, differentiated from other spinal intramedullary tumors. In this study, we analyzed frozen sections of spinal subependymomas to identify potential histological clues of spinal subependymomas to differentiate them from tumors that mimic spinal subependymoma. We reviewed the frozen sections and the corresponding permanent slides for 7 cases of spinal subependymoma. The spinal subependymomas showed several characteristic patterns, including, most importantly, an eccentric or both central and eccentric location in the axial plane. Histologically, they showed a (1) well-demarcated and multinodular mass with (2) low or moderate cellularity, (3) a microlobular pattern, and (4) small clusters of neoplastic cells. These features appear to be very specific to spinal subependymomas and could help differentiate them from ependymomas or astrocytomas. Although we might not be able to provide an exact diagnosis of all spinal subependymomas using these histological features, we hope that they help neuropathologists and neurosurgeons to adequately diagnose and treat spinal subependymomas.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalBrain Tumor Pathology
Volume33
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Subependymal Glioma
Frozen Sections
Neoplasms
Ependymoma
Astrocytoma
Spinal Cord

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

Choi, Seung Kyu ; Lee, Sang Hoon ; Kim, Byeongwoo ; Minn, Yang Ki ; Kim, Keung Nyun ; Kim, Se Hoon. / Findings from frozen sections of spinal subependymomas : Is it possible to differentiate this diagnosis from other common spinal tumors?. In: Brain Tumor Pathology. 2016 ; Vol. 33, No. 1. pp. 19-26.
@article{f7967a02392a47f39be4f16d1b4c6112,
title = "Findings from frozen sections of spinal subependymomas: Is it possible to differentiate this diagnosis from other common spinal tumors?",
abstract = "Subependymomas are slow-growing, benign neoplasms that are rarely found in the spinal cord. Because of the differences in the treatment plans, it might be very helpful for neurosurgeons to intraoperatively establish a diagnosis of spinal subependymoma, differentiated from other spinal intramedullary tumors. In this study, we analyzed frozen sections of spinal subependymomas to identify potential histological clues of spinal subependymomas to differentiate them from tumors that mimic spinal subependymoma. We reviewed the frozen sections and the corresponding permanent slides for 7 cases of spinal subependymoma. The spinal subependymomas showed several characteristic patterns, including, most importantly, an eccentric or both central and eccentric location in the axial plane. Histologically, they showed a (1) well-demarcated and multinodular mass with (2) low or moderate cellularity, (3) a microlobular pattern, and (4) small clusters of neoplastic cells. These features appear to be very specific to spinal subependymomas and could help differentiate them from ependymomas or astrocytomas. Although we might not be able to provide an exact diagnosis of all spinal subependymomas using these histological features, we hope that they help neuropathologists and neurosurgeons to adequately diagnose and treat spinal subependymomas.",
author = "Choi, {Seung Kyu} and Lee, {Sang Hoon} and Byeongwoo Kim and Minn, {Yang Ki} and Kim, {Keung Nyun} and Kim, {Se Hoon}",
year = "2016",
month = "1",
day = "1",
doi = "10.1007/s10014-015-0237-1",
language = "English",
volume = "33",
pages = "19--26",
journal = "Brain Tumor Pathology",
issn = "1433-7398",
publisher = "Springer Japan",
number = "1",

}

Findings from frozen sections of spinal subependymomas : Is it possible to differentiate this diagnosis from other common spinal tumors? / Choi, Seung Kyu; Lee, Sang Hoon; Kim, Byeongwoo; Minn, Yang Ki; Kim, Keung Nyun; Kim, Se Hoon.

In: Brain Tumor Pathology, Vol. 33, No. 1, 01.01.2016, p. 19-26.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Findings from frozen sections of spinal subependymomas

T2 - Is it possible to differentiate this diagnosis from other common spinal tumors?

AU - Choi, Seung Kyu

AU - Lee, Sang Hoon

AU - Kim, Byeongwoo

AU - Minn, Yang Ki

AU - Kim, Keung Nyun

AU - Kim, Se Hoon

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Subependymomas are slow-growing, benign neoplasms that are rarely found in the spinal cord. Because of the differences in the treatment plans, it might be very helpful for neurosurgeons to intraoperatively establish a diagnosis of spinal subependymoma, differentiated from other spinal intramedullary tumors. In this study, we analyzed frozen sections of spinal subependymomas to identify potential histological clues of spinal subependymomas to differentiate them from tumors that mimic spinal subependymoma. We reviewed the frozen sections and the corresponding permanent slides for 7 cases of spinal subependymoma. The spinal subependymomas showed several characteristic patterns, including, most importantly, an eccentric or both central and eccentric location in the axial plane. Histologically, they showed a (1) well-demarcated and multinodular mass with (2) low or moderate cellularity, (3) a microlobular pattern, and (4) small clusters of neoplastic cells. These features appear to be very specific to spinal subependymomas and could help differentiate them from ependymomas or astrocytomas. Although we might not be able to provide an exact diagnosis of all spinal subependymomas using these histological features, we hope that they help neuropathologists and neurosurgeons to adequately diagnose and treat spinal subependymomas.

AB - Subependymomas are slow-growing, benign neoplasms that are rarely found in the spinal cord. Because of the differences in the treatment plans, it might be very helpful for neurosurgeons to intraoperatively establish a diagnosis of spinal subependymoma, differentiated from other spinal intramedullary tumors. In this study, we analyzed frozen sections of spinal subependymomas to identify potential histological clues of spinal subependymomas to differentiate them from tumors that mimic spinal subependymoma. We reviewed the frozen sections and the corresponding permanent slides for 7 cases of spinal subependymoma. The spinal subependymomas showed several characteristic patterns, including, most importantly, an eccentric or both central and eccentric location in the axial plane. Histologically, they showed a (1) well-demarcated and multinodular mass with (2) low or moderate cellularity, (3) a microlobular pattern, and (4) small clusters of neoplastic cells. These features appear to be very specific to spinal subependymomas and could help differentiate them from ependymomas or astrocytomas. Although we might not be able to provide an exact diagnosis of all spinal subependymomas using these histological features, we hope that they help neuropathologists and neurosurgeons to adequately diagnose and treat spinal subependymomas.

UR - http://www.scopus.com/inward/record.url?scp=84953371085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953371085&partnerID=8YFLogxK

U2 - 10.1007/s10014-015-0237-1

DO - 10.1007/s10014-015-0237-1

M3 - Article

C2 - 26515302

AN - SCOPUS:84953371085

VL - 33

SP - 19

EP - 26

JO - Brain Tumor Pathology

JF - Brain Tumor Pathology

SN - 1433-7398

IS - 1

ER -