Fine-needle aspiration versus core needle biopsy for diagnosis of thyroid malignancy and neoplasm: a matched cohort study

Soo Yeon Kim, Hye Sun Lee, Jieun Moon, Eunkyung Kim, Hee Jung Moon, Jung Hyun Yoon, jinyoung kwak

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives: To compare the diagnostic performances of fine-needle aspiration (FNA) and core needle biopsy (CNB) in the diagnosis of thyroid malignancy and neoplasm in patients who underwent surgery for thyroid nodules. Methods: This retrospective study was approved by the institutional review board, and the need to obtain informed consent was waived. 3192 patients who underwent FNA (n = 3048) or CNB (n = 144) for diagnosis of thyroid nodules and then proceeded with surgery were included. Surgical pathologic diagnosis was the reference standard. Diagnostic performances of FNA and CNB to predict malignancy and neoplasm were compared. Propensity score matching was used to match patients with FNA with those with CNB because there were significant differences in the number of nodules and nodule characteristics between the FNA and CNB groups. Results: Before matching, the sensitivity and accuracy of FNA were significantly higher or comparable with those of CNB, and the specificity, negative predictive value and positive predictive value were comparable. After matching, the diagnostic performances were similar, with the exception of specificity for predicting neoplasm being higher with CNB than with FNA. Conclusion: FNA showed comparable diagnostic performance to CNB; therefore, there may be no benefit in performing CNB to diagnose papillary thyroid carcinoma and neoplasm. Key Points: • Diagnostic performances of FNA and CNB for thyroid malignancy and neoplasm were compared. • FNA showed comparable performances to CNB both before and after statistical matching. • There may be no benefit in performing CNB, given the comparable performances.

Original languageEnglish
Pages (from-to)801-811
Number of pages11
JournalEuropean Radiology
Volume27
Issue number2
DOIs
Publication statusPublished - 2017 Feb 1

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Large-Core Needle Biopsy
Fine Needle Biopsy
Thyroid Neoplasms
Cohort Studies
Neoplasms
Thyroid Nodule
Propensity Score
Research Ethics Committees
Informed Consent

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Kim, Soo Yeon ; Lee, Hye Sun ; Moon, Jieun ; Kim, Eunkyung ; Moon, Hee Jung ; Yoon, Jung Hyun ; kwak, jinyoung. / Fine-needle aspiration versus core needle biopsy for diagnosis of thyroid malignancy and neoplasm : a matched cohort study. In: European Radiology. 2017 ; Vol. 27, No. 2. pp. 801-811.
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Fine-needle aspiration versus core needle biopsy for diagnosis of thyroid malignancy and neoplasm : a matched cohort study. / Kim, Soo Yeon; Lee, Hye Sun; Moon, Jieun; Kim, Eunkyung; Moon, Hee Jung; Yoon, Jung Hyun; kwak, jinyoung.

In: European Radiology, Vol. 27, No. 2, 01.02.2017, p. 801-811.

Research output: Contribution to journalArticle

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AU - Kim, Soo Yeon

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