First report of the carbapenemase gene blaOXA-499 in Acinetobacter pittii

Roshan D'Souza, Naina Adren Pinto, Paul G. Higgins, Insik Hwang, Dongeun Yong, Jongrak Choi, Kyoungwon Lee, Yunsop Chong

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible Acinetobacter spp., we were able to show that OXA-499 confers resistance to carbapenems.

Original languageEnglish
Article numbere02676
JournalAntimicrobial agents and chemotherapy
Volume61
Issue number5
DOIs
Publication statusPublished - 2017 May

Fingerprint

Acinetobacter
Genes
Carbapenems
Organism Cloning
Chromosomes
Amino Acids
Asp(5)-oxytocin
carbapenemase

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

D'Souza, R., Pinto, N. A., Higgins, P. G., Hwang, I., Yong, D., Choi, J., ... Chong, Y. (2017). First report of the carbapenemase gene blaOXA-499 in Acinetobacter pittii. Antimicrobial agents and chemotherapy, 61(5), [e02676]. https://doi.org/10.1128/AAC.02676-16
D'Souza, Roshan ; Pinto, Naina Adren ; Higgins, Paul G. ; Hwang, Insik ; Yong, Dongeun ; Choi, Jongrak ; Lee, Kyoungwon ; Chong, Yunsop. / First report of the carbapenemase gene blaOXA-499 in Acinetobacter pittii. In: Antimicrobial agents and chemotherapy. 2017 ; Vol. 61, No. 5.
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abstract = "We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1{\%} amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible Acinetobacter spp., we were able to show that OXA-499 confers resistance to carbapenems.",
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D'Souza, R, Pinto, NA, Higgins, PG, Hwang, I, Yong, D, Choi, J, Lee, K & Chong, Y 2017, 'First report of the carbapenemase gene blaOXA-499 in Acinetobacter pittii', Antimicrobial agents and chemotherapy, vol. 61, no. 5, e02676. https://doi.org/10.1128/AAC.02676-16

First report of the carbapenemase gene blaOXA-499 in Acinetobacter pittii. / D'Souza, Roshan; Pinto, Naina Adren; Higgins, Paul G.; Hwang, Insik; Yong, Dongeun; Choi, Jongrak; Lee, Kyoungwon; Chong, Yunsop.

In: Antimicrobial agents and chemotherapy, Vol. 61, No. 5, e02676, 05.2017.

Research output: Contribution to journalArticle

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AU - D'Souza, Roshan

AU - Pinto, Naina Adren

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AU - Hwang, Insik

AU - Yong, Dongeun

AU - Choi, Jongrak

AU - Lee, Kyoungwon

AU - Chong, Yunsop

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AB - We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible Acinetobacter spp., we were able to show that OXA-499 confers resistance to carbapenems.

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