First report of the carbapenemase gene blaOXA-499 in Acinetobacter pittii

Roshan D'Souza, Naina Adren Pinto, Paul G. Higgins, Insik Hwang, Dongeun Yong, Jongrak Choi, Kyoungwon Lee, Yunsop Chong

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3 Citations (Scopus)

Abstract

We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible Acinetobacter spp., we were able to show that OXA-499 confers resistance to carbapenems.

Original languageEnglish
Article numbere02676
JournalAntimicrobial agents and chemotherapy
Volume61
Issue number5
DOIs
Publication statusPublished - 2017 May

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    D'Souza, R., Pinto, N. A., Higgins, P. G., Hwang, I., Yong, D., Choi, J., Lee, K., & Chong, Y. (2017). First report of the carbapenemase gene blaOXA-499 in Acinetobacter pittii. Antimicrobial agents and chemotherapy, 61(5), [e02676]. https://doi.org/10.1128/AAC.02676-16