Abstract
We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible Acinetobacter spp., we were able to show that OXA-499 confers resistance to carbapenems.
| Original language | English |
|---|---|
| Article number | e02676 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 61 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2017 May |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
Cite this
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First report of the carbapenemase gene blaOXA-499 in Acinetobacter pittii. / D'Souza, Roshan; Pinto, Naina Adren; Higgins, Paul G.; Hwang, Insik; Yong, Dongeun; Choi, Jongrak; Lee, Kyoungwon; Chong, Yunsop.
In: Antimicrobial agents and chemotherapy, Vol. 61, No. 5, e02676, 05.2017.Research output: Contribution to journal › Article
TY - JOUR
T1 - First report of the carbapenemase gene blaOXA-499 in Acinetobacter pittii
AU - D'Souza, Roshan
AU - Pinto, Naina Adren
AU - Higgins, Paul G.
AU - Hwang, Insik
AU - Yong, Dongeun
AU - Choi, Jongrak
AU - Lee, Kyoungwon
AU - Chong, Yunsop
PY - 2017/5
Y1 - 2017/5
N2 - We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible Acinetobacter spp., we were able to show that OXA-499 confers resistance to carbapenems.
AB - We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible Acinetobacter spp., we were able to show that OXA-499 confers resistance to carbapenems.
UR - http://www.scopus.com/inward/record.url?scp=85018303144&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85018303144&partnerID=8YFLogxK
U2 - 10.1128/AAC.02676-16
DO - 10.1128/AAC.02676-16
M3 - Article
C2 - 28264850
AN - SCOPUS:85018303144
VL - 61
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 5
M1 - e02676
ER -