First report of the carbapenemase gene blaOXA-499 in Acinetobacter pittii

Roshan D'Souza; Naina Adren Pinto; Paul G. Higgins; Insik Hwang; Dongeun Yong; Jongrak Choi; Kyoungwon Lee; Yunsop Chong

doi:10.1128/AAC.02676-16

First report of the carbapenemase gene bla_OXA-499 in Acinetobacter pittii

Roshan D'Souza, Naina Adren Pinto, Paul G. Higgins, Insik Hwang, Dongeun Yong, Jongrak Choi, Kyoungwon Lee, Yunsop Chong

Department of Laboratory Medicine

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

We identified the carbapenemase gene bla_OXA-499, a variant of bla_OXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible Acinetobacter spp., we were able to show that OXA-499 confers resistance to carbapenems.

Original language	English
Article number	e02676
Journal	Antimicrobial agents and chemotherapy
Volume	61
Issue number	5
DOIs	https://doi.org/10.1128/AAC.02676-16
Publication status	Published - 2017 May

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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D'Souza, R., Pinto, N. A., Higgins, P. G., Hwang, I., Yong, D., Choi, J., Lee, K., & Chong, Y. (2017). First report of the carbapenemase gene bla_OXA-499 in Acinetobacter pittii. Antimicrobial agents and chemotherapy, 61(5), [e02676]. https://doi.org/10.1128/AAC.02676-16

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abstract = "We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible Acinetobacter spp., we were able to show that OXA-499 confers resistance to carbapenems.",

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AU - Lee, Kyoungwon

AU - Chong, Yunsop

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