Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia

Seonju Park, Nguyen Xuan Nhiem, Phan Van Kiem, Chau Van Minh, Bui Huu Tai, Nanyoung Kim, Hye Hyun Yoo, Jae Hyoung Song, Hyun Jeong Ko, Seung Hyun Kim

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Eurycoma longifolia has been widely used for various traditional medicinal purposes in South-East Asia. In this study, five new quassinoids, eurylactone E (1), eurylactone F (2), eurylactone G (3), eurycomalide D (4), and eurycomalide E (5), along with ten known quassinoids (6-15) were isolated from the roots of E. longifolia. Their structures were determined by extensive spectroscopic methods, including 1D and 2D NMR, and MS spectra data. Among the isolated compounds, 13β-methyl,21-dihydroeurycomanone (6) has been reported as a synthetic derivative. However, it was isolated from the natural product for the first time in this study. The cytotoxic activities of fifteen compounds were evaluated against human lung cancer cell line, A549 and human cervical cancer cell line, HeLa.

Original languageEnglish
Pages (from-to)3835-3840
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number16
DOIs
Publication statusPublished - 2014 Aug 15

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Eurycoma
Quassins
Cells
Far East
Biological Products
Uterine Cervical Neoplasms
Lung Neoplasms
Nuclear magnetic resonance
Derivatives
Cell Line

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Park, Seonju ; Nhiem, Nguyen Xuan ; Kiem, Phan Van ; Minh, Chau Van ; Tai, Bui Huu ; Kim, Nanyoung ; Yoo, Hye Hyun ; Song, Jae Hyoung ; Ko, Hyun Jeong ; Kim, Seung Hyun. / Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia. In: Bioorganic and Medicinal Chemistry Letters. 2014 ; Vol. 24, No. 16. pp. 3835-3840.
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Park, S, Nhiem, NX, Kiem, PV, Minh, CV, Tai, BH, Kim, N, Yoo, HH, Song, JH, Ko, HJ & Kim, SH 2014, 'Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia', Bioorganic and Medicinal Chemistry Letters, vol. 24, no. 16, pp. 3835-3840. https://doi.org/10.1016/j.bmcl.2014.06.058

Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia. / Park, Seonju; Nhiem, Nguyen Xuan; Kiem, Phan Van; Minh, Chau Van; Tai, Bui Huu; Kim, Nanyoung; Yoo, Hye Hyun; Song, Jae Hyoung; Ko, Hyun Jeong; Kim, Seung Hyun.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 24, No. 16, 15.08.2014, p. 3835-3840.

Research output: Contribution to journalArticle

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AU - Kiem, Phan Van

AU - Minh, Chau Van

AU - Tai, Bui Huu

AU - Kim, Nanyoung

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AU - Song, Jae Hyoung

AU - Ko, Hyun Jeong

AU - Kim, Seung Hyun

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