Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia

Seonju Park; Nguyen Xuan Nhiem; Phan Van Kiem; Chau Van Minh; Bui Huu Tai; Nanyoung Kim; Hye Hyun Yoo; Jae Hyoung Song; Hyun Jeong Ko; Seung Hyun Kim

doi:10.1016/j.bmcl.2014.06.058

Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia

Seonju Park, Nguyen Xuan Nhiem, Phan Van Kiem, Chau Van Minh, Bui Huu Tai, Nanyoung Kim, Hye Hyun Yoo, Jae Hyoung Song, Hyun Jeong Ko, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Eurycoma longifolia has been widely used for various traditional medicinal purposes in South-East Asia. In this study, five new quassinoids, eurylactone E (1), eurylactone F (2), eurylactone G (3), eurycomalide D (4), and eurycomalide E (5), along with ten known quassinoids (6-15) were isolated from the roots of E. longifolia. Their structures were determined by extensive spectroscopic methods, including 1D and 2D NMR, and MS spectra data. Among the isolated compounds, 13β-methyl,21-dihydroeurycomanone (6) has been reported as a synthetic derivative. However, it was isolated from the natural product for the first time in this study. The cytotoxic activities of fifteen compounds were evaluated against human lung cancer cell line, A549 and human cervical cancer cell line, HeLa.

Original language	English
Pages (from-to)	3835-3840
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	24
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2014.06.058
Publication status	Published - 2014 Aug 15

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2014.06.058

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title = "Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia",

abstract = "Eurycoma longifolia has been widely used for various traditional medicinal purposes in South-East Asia. In this study, five new quassinoids, eurylactone E (1), eurylactone F (2), eurylactone G (3), eurycomalide D (4), and eurycomalide E (5), along with ten known quassinoids (6-15) were isolated from the roots of E. longifolia. Their structures were determined by extensive spectroscopic methods, including 1D and 2D NMR, and MS spectra data. Among the isolated compounds, 13β-methyl,21-dihydroeurycomanone (6) has been reported as a synthetic derivative. However, it was isolated from the natural product for the first time in this study. The cytotoxic activities of fifteen compounds were evaluated against human lung cancer cell line, A549 and human cervical cancer cell line, HeLa.",

author = "Seonju Park and Nhiem, {Nguyen Xuan} and Kiem, {Phan Van} and Minh, {Chau Van} and Tai, {Bui Huu} and Nanyoung Kim and Yoo, {Hye Hyun} and Song, {Jae Hyoung} and Ko, {Hyun Jeong} and Kim, {Seung Hyun}",

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doi = "10.1016/j.bmcl.2014.06.058",

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AU - Park, Seonju

AU - Nhiem, Nguyen Xuan

AU - Kiem, Phan Van

AU - Minh, Chau Van

AU - Tai, Bui Huu

AU - Kim, Nanyoung

AU - Yoo, Hye Hyun

AU - Song, Jae Hyoung

AU - Ko, Hyun Jeong

AU - Kim, Seung Hyun

PY - 2014/8/15

Y1 - 2014/8/15

N2 - Eurycoma longifolia has been widely used for various traditional medicinal purposes in South-East Asia. In this study, five new quassinoids, eurylactone E (1), eurylactone F (2), eurylactone G (3), eurycomalide D (4), and eurycomalide E (5), along with ten known quassinoids (6-15) were isolated from the roots of E. longifolia. Their structures were determined by extensive spectroscopic methods, including 1D and 2D NMR, and MS spectra data. Among the isolated compounds, 13β-methyl,21-dihydroeurycomanone (6) has been reported as a synthetic derivative. However, it was isolated from the natural product for the first time in this study. The cytotoxic activities of fifteen compounds were evaluated against human lung cancer cell line, A549 and human cervical cancer cell line, HeLa.

AB - Eurycoma longifolia has been widely used for various traditional medicinal purposes in South-East Asia. In this study, five new quassinoids, eurylactone E (1), eurylactone F (2), eurylactone G (3), eurycomalide D (4), and eurycomalide E (5), along with ten known quassinoids (6-15) were isolated from the roots of E. longifolia. Their structures were determined by extensive spectroscopic methods, including 1D and 2D NMR, and MS spectra data. Among the isolated compounds, 13β-methyl,21-dihydroeurycomanone (6) has been reported as a synthetic derivative. However, it was isolated from the natural product for the first time in this study. The cytotoxic activities of fifteen compounds were evaluated against human lung cancer cell line, A549 and human cervical cancer cell line, HeLa.

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Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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