Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia

Seonju Park, Nguyen Xuan Nhiem, Phan Van Kiem, Chau Van Minh, Bui Huu Tai, Nanyoung Kim, Hye Hyun Yoo, Jae Hyoung Song, Hyun Jeong Ko, Seung Hyun Kim

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24 Citations (Scopus)

Abstract

Eurycoma longifolia has been widely used for various traditional medicinal purposes in South-East Asia. In this study, five new quassinoids, eurylactone E (1), eurylactone F (2), eurylactone G (3), eurycomalide D (4), and eurycomalide E (5), along with ten known quassinoids (6-15) were isolated from the roots of E. longifolia. Their structures were determined by extensive spectroscopic methods, including 1D and 2D NMR, and MS spectra data. Among the isolated compounds, 13β-methyl,21-dihydroeurycomanone (6) has been reported as a synthetic derivative. However, it was isolated from the natural product for the first time in this study. The cytotoxic activities of fifteen compounds were evaluated against human lung cancer cell line, A549 and human cervical cancer cell line, HeLa.

Original languageEnglish
Pages (from-to)3835-3840
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number16
DOIs
Publication statusPublished - 2014 Aug 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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    Park, S., Nhiem, N. X., Kiem, P. V., Minh, C. V., Tai, B. H., Kim, N., Yoo, H. H., Song, J. H., Ko, H. J., & Kim, S. H. (2014). Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia. Bioorganic and Medicinal Chemistry Letters, 24(16), 3835-3840. https://doi.org/10.1016/j.bmcl.2014.06.058