Five-year clinical outcomes of the first Korean-made sirolimus-eluting coronary stent with abluminal biodegradable polymer

Kyoung Woo Seo, Hyoung Mo Yang, Junghan Yoon, Hyo Soo Kim, Kiyuk Chang, Hong Seok Lim, Byoung Joo Choi, So Yeon Choi, Myeong Ho Yoon, Seung Hwan Lee, Sung Gyun Ahn, Young Jin Youn, Jun Won Lee, Bon Kwon Koo, Kyung Woo Park, Han Mo Yang, Jung Kyu Han, Wook Sung Chung, Hun Jun Park, Byung Hee HwangEun Ho Choo, Gyu Chul Oh, Seung Jea Tahk

Research output: Contribution to journalArticlepeer-review

Abstract

ABSTRACT: This study evaluated the 5-year clinical outcomes of the Genoss DES, the first Korean-made sirolimus-eluting coronary stent with abluminal biodegradable polymer.We previously conducted the first-in-patient prospective, multicenter, randomized trial with a 1:1 ratio of patients using the Genoss DES and Promus Element stents; the angiographic and clinical outcomes of the Genoss DES stent were comparable to those of the Promus Element stent. The primary endpoint was major adverse cardiac events (MACE), which was a composite of death, myocardial infarction (MI), and target lesion revascularization (TLR) at 5 years.We enrolled 38 patients in the Genoss DES group and 39 in the Promus Element group. Thirty-eight patients (100%) from the Genoss DES group and 38 (97.4%) from the Promus Element group were followed up at 5 years. The rates of MACE (5.3% vs 12.8%, P = .431), death (5.3% vs 10.3%, P = .675), TLR (2.6% vs 2.6%, P = 1.000), and target vessel revascularization (TVR) (7.9% vs 2.6%, P = .358) at 5 years did not differ significantly between the groups. No TLR or target vessel revascularization was reported from years 1 to 5 after the index procedure, and no MI or stent thrombosis occurred in either group during 5 years.The biodegradable polymer Genoss DES and durable polymer Promus Element stents showed comparable low rates of MACE at the 5-year clinical follow-up.

Original languageEnglish
Pages (from-to)e25765
JournalMedicine
Volume100
Issue number19
DOIs
Publication statusPublished - 2021 May 14

Bibliographical note

Publisher Copyright:
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Five-year clinical outcomes of the first Korean-made sirolimus-eluting coronary stent with abluminal biodegradable polymer'. Together they form a unique fingerprint.

Cite this