Flavin-Based Light-Driven Fluorescent Probe for the Detection of Antioxidant Amino Acids

Kyeong Im Hong; Seong Min Lee; Woo Dong Jang

doi:10.1002/open.201700144

Flavin-Based Light-Driven Fluorescent Probe for the Detection of Antioxidant Amino Acids

Kyeong Im Hong, Seong Min Lee, Woo Dong Jang

Department of Chemistry

Research output: Contribution to journal › Article

Abstract

We have synthesized a flavin-N(5)-oxide derivative with a p-toluenesulfonyl (Ts-OF) group as a “turn-on” fluorescent probe for the detection of several antioxidant amino acids and biothiols. Oxidized flavin was synthesized by using dithiothreitol as the reducing agent. Ts-OF showed a light-driven fluorescence enhancement in the presence of several amino acids and biothiols such as histidine (His), methionine (Met), cysteine (Cys), glutathione (GSH), and homocysteine (Hcy). The ¹H NMR study indicated the reductive elimination of the p-toluenesulfonyl group from Ts-OF in the presence of antioxidants and photo-irradiation.

Original language	English
Pages (from-to)	57-60
Number of pages	4
Journal	ChemistryOpen
Volume	7
Issue number	1
DOIs	https://doi.org/10.1002/open.201700144
Publication status	Published - 2018 Jan

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All Science Journal Classification (ASJC) codes

Chemistry(all)

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Hong, K. I., Lee, S. M., & Jang, W. D. (2018). Flavin-Based Light-Driven Fluorescent Probe for the Detection of Antioxidant Amino Acids. ChemistryOpen, 7(1), 57-60. https://doi.org/10.1002/open.201700144

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10.1002/open.201700144