Flexible electronic/optoelectronic microsystems with scalable designs for chronic biointegration

Enming Song, Chia Han Chiang, Rui Li, Xin Jin, Jianing Zhao, Mackenna Hill, Yu Xia, Lizhu Li, Yuming Huang, Sang Min Won, Ki Jun Yu, Xing Sheng, Hui Fang, Muhammad Ashraful Alam, Yonggang Huang, Jonathan Viventi, Jan Kai Chang, John A. Rogers

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Flexible biocompatible electronic systems that leverage key materials and manufacturing techniques associated with the consumer electronics industry have potential for broad applications in biomedicine and biological research. This study reports scalable approaches to technologies of this type where thin microscale device components integrate onto flexible polymer substrates in interconnected arrays to provide multimodal high performance operational capabilities as intimately coupled biointerfaces. Specificially the material options and engineering schemes summarized here serve as foundations for diverse heterogeneously integrated systems. Scaled examples incorporate >32,000 silicon microdie and inorganic microscale light-emitting diodes derived from wafer sources distributed at variable pitch spacings and fill factors across large areas on polymer films at full organ-scale dimensions such as human brain over ~150 cm2. In vitro studies and accelerated testing in simulated biofluids together with theoretical simulations of underlying processes yield quantitative insights into the key materials aspects. The results suggest an ability of these systems to operate in a biologically safe stable fashion with projected lifetimes of several decades without leakage currents or reductions in performance. The versatility of these combined concepts suggests applicability to many classes of biointegrated semiconductor devices.

Original languageEnglish
Pages (from-to)15398-15406
Number of pages9
JournalProceedings of the National Academy of Sciences of the United States of America
Volume116
Issue number31
DOIs
Publication statusPublished - 2019 Jul 30

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Polymers
Equipment and Supplies
Semiconductors
Silicon
Industry
Technology
Light
Brain
Research
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • General

Cite this

Song, Enming ; Chiang, Chia Han ; Li, Rui ; Jin, Xin ; Zhao, Jianing ; Hill, Mackenna ; Xia, Yu ; Li, Lizhu ; Huang, Yuming ; Won, Sang Min ; Yu, Ki Jun ; Sheng, Xing ; Fang, Hui ; Alam, Muhammad Ashraful ; Huang, Yonggang ; Viventi, Jonathan ; Chang, Jan Kai ; Rogers, John A. / Flexible electronic/optoelectronic microsystems with scalable designs for chronic biointegration. In: Proceedings of the National Academy of Sciences of the United States of America. 2019 ; Vol. 116, No. 31. pp. 15398-15406.
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abstract = "Flexible biocompatible electronic systems that leverage key materials and manufacturing techniques associated with the consumer electronics industry have potential for broad applications in biomedicine and biological research. This study reports scalable approaches to technologies of this type where thin microscale device components integrate onto flexible polymer substrates in interconnected arrays to provide multimodal high performance operational capabilities as intimately coupled biointerfaces. Specificially the material options and engineering schemes summarized here serve as foundations for diverse heterogeneously integrated systems. Scaled examples incorporate >32,000 silicon microdie and inorganic microscale light-emitting diodes derived from wafer sources distributed at variable pitch spacings and fill factors across large areas on polymer films at full organ-scale dimensions such as human brain over ~150 cm2. In vitro studies and accelerated testing in simulated biofluids together with theoretical simulations of underlying processes yield quantitative insights into the key materials aspects. The results suggest an ability of these systems to operate in a biologically safe stable fashion with projected lifetimes of several decades without leakage currents or reductions in performance. The versatility of these combined concepts suggests applicability to many classes of biointegrated semiconductor devices.",
author = "Enming Song and Chiang, {Chia Han} and Rui Li and Xin Jin and Jianing Zhao and Mackenna Hill and Yu Xia and Lizhu Li and Yuming Huang and Won, {Sang Min} and Yu, {Ki Jun} and Xing Sheng and Hui Fang and Alam, {Muhammad Ashraful} and Yonggang Huang and Jonathan Viventi and Chang, {Jan Kai} and Rogers, {John A.}",
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Song, E, Chiang, CH, Li, R, Jin, X, Zhao, J, Hill, M, Xia, Y, Li, L, Huang, Y, Won, SM, Yu, KJ, Sheng, X, Fang, H, Alam, MA, Huang, Y, Viventi, J, Chang, JK & Rogers, JA 2019, 'Flexible electronic/optoelectronic microsystems with scalable designs for chronic biointegration', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 31, pp. 15398-15406. https://doi.org/10.1073/pnas.1907697116

Flexible electronic/optoelectronic microsystems with scalable designs for chronic biointegration. / Song, Enming; Chiang, Chia Han; Li, Rui; Jin, Xin; Zhao, Jianing; Hill, Mackenna; Xia, Yu; Li, Lizhu; Huang, Yuming; Won, Sang Min; Yu, Ki Jun; Sheng, Xing; Fang, Hui; Alam, Muhammad Ashraful; Huang, Yonggang; Viventi, Jonathan; Chang, Jan Kai; Rogers, John A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 31, 30.07.2019, p. 15398-15406.

Research output: Contribution to journalArticle

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AU - Song, Enming

AU - Chiang, Chia Han

AU - Li, Rui

AU - Jin, Xin

AU - Zhao, Jianing

AU - Hill, Mackenna

AU - Xia, Yu

AU - Li, Lizhu

AU - Huang, Yuming

AU - Won, Sang Min

AU - Yu, Ki Jun

AU - Sheng, Xing

AU - Fang, Hui

AU - Alam, Muhammad Ashraful

AU - Huang, Yonggang

AU - Viventi, Jonathan

AU - Chang, Jan Kai

AU - Rogers, John A.

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