Flexible microbubble-based Fabry–Pérot cavity for sensitive ultrasound detection and wide-view photoacoustic imaging

Jun Ma, Yang He, Xue Bai, Li Peng Sun, Kai Chen, Kyunghwan Oh, Bai Ou Guan

Research output: Contribution to journalArticlepeer-review

Abstract

Interaction of acoustic waves and microbubbles occurs in numerous biomedical applications including ultrasound imaging, drug delivery, lithotripsy treatment, and cell manipulation, wherein the acoustically driven microbubbles routinely act as active microscale oscillators or actuators. In contrast, microbubbles were utilized here as passive receivers to detect broadband ultrasound waves in aqueous environments. The microbubble was photothermally generated on a microstructured optical fiber (MOF) tip, forming a flexible Fabry–Pérot cavity whose gas–water interface was sensitive to ultrasound waves. The MOF severed as both a low-loss waveguide and a compact light condenser, allowing high-efficiency generation and stabilization of ultrasmall microbubbles. Integrated with all-fiber interferometry, a 10 μm diameter microbubble exhibited a low noise-equivalent pressure level of ∼3.4 mPa∕Hz12 and a broad bandwidth of ∼0.8 MHz, capable of detecting weak ultrasounds emitted from red blood cells irradiated by pulsed laser light. With advantages of high sensitivity, compact size, and low cost, the microbubble-based ultrasound sensor has great potential in biomedical imaging and sensing applications.

Original languageEnglish
Pages (from-to)1558-1565
Number of pages8
JournalPhotonics Research
Volume8
Issue number10
DOIs
Publication statusPublished - 2020 Oct 1

Bibliographical note

Funding Information:
Funding. Guangzhou Science and Technology Plan Project (201904020032); The Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2019BT02X105); National Natural Science Foundation of China (61705082, U1701268); Natural Science Foundation of Guangdong Province (2017A030313361, 2018030310587); Fundamental Research Funds for the Central Universities (21617304); Province High-Level Talents Introduction Plan (2017GC010420).

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Fingerprint Dive into the research topics of 'Flexible microbubble-based Fabry–Pérot cavity for sensitive ultrasound detection and wide-view photoacoustic imaging'. Together they form a unique fingerprint.

Cite this