Flow-suppressed hyperpolarized 13C chemical shift imaging using velocity-optimized bipolar gradient in mouse liver tumors at 9.4 T

Hansol Lee, Joonsung Lee, Eunhae Joe, Seungwook Yang, Jae Eun Song, Young Suk Choi, Eunkyung Wang, Chan Gyu Joo, Ho Taek Song, Donghyun Kim

Research output: Contribution to journalArticle

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Abstract

Purpose: To optimize and investigate the influence of bipolar gradients for flow suppression in metabolic quantification of hyperpolarized 13C chemical shift imaging (CSI) of mouse liver at 9.4 T. Methods: The trade-off between the amount of flow suppression using bipolar gradients and T2* effect from static spins was simulated. A free induction decay CSI sequence with alternations between the flow-suppressed and non–flow-suppressed acquisitions for each repetition time was developed and was applied to liver tumor–bearing mice via injection of hyperpolarized [1-13C] pyruvate. Results: The in vivo results from flow suppression using the velocity-optimized bipolar gradient were comparable with the simulation results. The vascular signal was adequately suppressed and signal loss in stationary tissue was minimized. Application of the velocity-optimized bipolar gradient to tumor-bearing mice showed reduction in the vessel-derived pyruvate signal contamination, and the average lactate/pyruvate ratio increased by 0.095 (P < 0.05) in the tumor region after flow suppression. Conclusion: Optimization of the bipolar gradient is essential because of the short 13C T2* and high signal in venous flow in the mouse liver. The proposed velocity-optimized bipolar gradient can suppress the vascular signal, minimizing T2*-related signal loss in stationary tissues at 9.4 T. Magn Reson Med 78:1674–1682, 2017.

Original languageEnglish
Pages (from-to)1674-1682
Number of pages9
JournalMagnetic Resonance in Medicine
Volume78
Issue number5
DOIs
Publication statusPublished - 2017 Nov 1

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Pyruvic Acid
Magnetic Resonance Imaging
Liver
Blood Vessels
Neoplasms
Lactic Acid
Injections

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Lee, Hansol ; Lee, Joonsung ; Joe, Eunhae ; Yang, Seungwook ; Song, Jae Eun ; Choi, Young Suk ; Wang, Eunkyung ; Joo, Chan Gyu ; Song, Ho Taek ; Kim, Donghyun. / Flow-suppressed hyperpolarized 13C chemical shift imaging using velocity-optimized bipolar gradient in mouse liver tumors at 9.4 T. In: Magnetic Resonance in Medicine. 2017 ; Vol. 78, No. 5. pp. 1674-1682.
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abstract = "Purpose: To optimize and investigate the influence of bipolar gradients for flow suppression in metabolic quantification of hyperpolarized 13C chemical shift imaging (CSI) of mouse liver at 9.4 T. Methods: The trade-off between the amount of flow suppression using bipolar gradients and T2* effect from static spins was simulated. A free induction decay CSI sequence with alternations between the flow-suppressed and non–flow-suppressed acquisitions for each repetition time was developed and was applied to liver tumor–bearing mice via injection of hyperpolarized [1-13C] pyruvate. Results: The in vivo results from flow suppression using the velocity-optimized bipolar gradient were comparable with the simulation results. The vascular signal was adequately suppressed and signal loss in stationary tissue was minimized. Application of the velocity-optimized bipolar gradient to tumor-bearing mice showed reduction in the vessel-derived pyruvate signal contamination, and the average lactate/pyruvate ratio increased by 0.095 (P < 0.05) in the tumor region after flow suppression. Conclusion: Optimization of the bipolar gradient is essential because of the short 13C T2* and high signal in venous flow in the mouse liver. The proposed velocity-optimized bipolar gradient can suppress the vascular signal, minimizing T2*-related signal loss in stationary tissues at 9.4 T. Magn Reson Med 78:1674–1682, 2017.",
author = "Hansol Lee and Joonsung Lee and Eunhae Joe and Seungwook Yang and Song, {Jae Eun} and Choi, {Young Suk} and Eunkyung Wang and Joo, {Chan Gyu} and Song, {Ho Taek} and Donghyun Kim",
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Flow-suppressed hyperpolarized 13C chemical shift imaging using velocity-optimized bipolar gradient in mouse liver tumors at 9.4 T. / Lee, Hansol; Lee, Joonsung; Joe, Eunhae; Yang, Seungwook; Song, Jae Eun; Choi, Young Suk; Wang, Eunkyung; Joo, Chan Gyu; Song, Ho Taek; Kim, Donghyun.

In: Magnetic Resonance in Medicine, Vol. 78, No. 5, 01.11.2017, p. 1674-1682.

Research output: Contribution to journalArticle

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T1 - Flow-suppressed hyperpolarized 13C chemical shift imaging using velocity-optimized bipolar gradient in mouse liver tumors at 9.4 T

AU - Lee, Hansol

AU - Lee, Joonsung

AU - Joe, Eunhae

AU - Yang, Seungwook

AU - Song, Jae Eun

AU - Choi, Young Suk

AU - Wang, Eunkyung

AU - Joo, Chan Gyu

AU - Song, Ho Taek

AU - Kim, Donghyun

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Purpose: To optimize and investigate the influence of bipolar gradients for flow suppression in metabolic quantification of hyperpolarized 13C chemical shift imaging (CSI) of mouse liver at 9.4 T. Methods: The trade-off between the amount of flow suppression using bipolar gradients and T2* effect from static spins was simulated. A free induction decay CSI sequence with alternations between the flow-suppressed and non–flow-suppressed acquisitions for each repetition time was developed and was applied to liver tumor–bearing mice via injection of hyperpolarized [1-13C] pyruvate. Results: The in vivo results from flow suppression using the velocity-optimized bipolar gradient were comparable with the simulation results. The vascular signal was adequately suppressed and signal loss in stationary tissue was minimized. Application of the velocity-optimized bipolar gradient to tumor-bearing mice showed reduction in the vessel-derived pyruvate signal contamination, and the average lactate/pyruvate ratio increased by 0.095 (P < 0.05) in the tumor region after flow suppression. Conclusion: Optimization of the bipolar gradient is essential because of the short 13C T2* and high signal in venous flow in the mouse liver. The proposed velocity-optimized bipolar gradient can suppress the vascular signal, minimizing T2*-related signal loss in stationary tissues at 9.4 T. Magn Reson Med 78:1674–1682, 2017.

AB - Purpose: To optimize and investigate the influence of bipolar gradients for flow suppression in metabolic quantification of hyperpolarized 13C chemical shift imaging (CSI) of mouse liver at 9.4 T. Methods: The trade-off between the amount of flow suppression using bipolar gradients and T2* effect from static spins was simulated. A free induction decay CSI sequence with alternations between the flow-suppressed and non–flow-suppressed acquisitions for each repetition time was developed and was applied to liver tumor–bearing mice via injection of hyperpolarized [1-13C] pyruvate. Results: The in vivo results from flow suppression using the velocity-optimized bipolar gradient were comparable with the simulation results. The vascular signal was adequately suppressed and signal loss in stationary tissue was minimized. Application of the velocity-optimized bipolar gradient to tumor-bearing mice showed reduction in the vessel-derived pyruvate signal contamination, and the average lactate/pyruvate ratio increased by 0.095 (P < 0.05) in the tumor region after flow suppression. Conclusion: Optimization of the bipolar gradient is essential because of the short 13C T2* and high signal in venous flow in the mouse liver. The proposed velocity-optimized bipolar gradient can suppress the vascular signal, minimizing T2*-related signal loss in stationary tissues at 9.4 T. Magn Reson Med 78:1674–1682, 2017.

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