Fluid flow analysis in microfluidic devices by spectral-domain optical Doppler tomography

Mark C. Pierce, Chulmin Joo, Barry Cense, Eli Weinberg, B. Hyle Park, Mircea Mujat, Jeffrey Borenstein, Guillermo J. Tearney, Brett E. Bouma, Johannes F. De Boer

Research output: Contribution to journalConference article

2 Citations (Scopus)

Abstract

Microfluidic devices are becoming increasingly popular for many applications, enabling biological and chemical reactions to be performed with nano- and picoliter sample volumes. Accurate measurement and monitoring of fluid flow behavior in the small channels of microfluidic systems is important for evaluating the performance of existing devices, and in the modeling and design of new microfluidic networks. We present here the results of experiments using spectral-domain optical Doppler tomography (SD-ODT) to measure fluid flow in single-layer microfluidic devices. The principles behind flow imaging with SD-ODT are reviewed, a method for velocity calibration is described, and cross-sectional and en-face images of fluid velocity in microfluidic channels are presented.

Original languageEnglish
Article number47
Pages (from-to)271-275
Number of pages5
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume5690
DOIs
Publication statusPublished - 2005 Jul 21

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Lab-On-A-Chip Devices
Optical Tomography
Microfluidics
microfluidic devices
fluid flow
Tomography
Flow of fluids
tomography
chemical reactions
Calibration
fluids
Equipment and Supplies
Chemical reactions
Imaging techniques
Fluids
Monitoring

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Pierce, Mark C. ; Joo, Chulmin ; Cense, Barry ; Weinberg, Eli ; Park, B. Hyle ; Mujat, Mircea ; Borenstein, Jeffrey ; Tearney, Guillermo J. ; Bouma, Brett E. ; De Boer, Johannes F. / Fluid flow analysis in microfluidic devices by spectral-domain optical Doppler tomography. In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2005 ; Vol. 5690. pp. 271-275.
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Pierce, MC, Joo, C, Cense, B, Weinberg, E, Park, BH, Mujat, M, Borenstein, J, Tearney, GJ, Bouma, BE & De Boer, JF 2005, 'Fluid flow analysis in microfluidic devices by spectral-domain optical Doppler tomography', Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 5690, 47, pp. 271-275. https://doi.org/10.1117/12.592864

Fluid flow analysis in microfluidic devices by spectral-domain optical Doppler tomography. / Pierce, Mark C.; Joo, Chulmin; Cense, Barry; Weinberg, Eli; Park, B. Hyle; Mujat, Mircea; Borenstein, Jeffrey; Tearney, Guillermo J.; Bouma, Brett E.; De Boer, Johannes F.

In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 5690, 47, 21.07.2005, p. 271-275.

Research output: Contribution to journalConference article

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AU - Joo, Chulmin

AU - Cense, Barry

AU - Weinberg, Eli

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AU - Mujat, Mircea

AU - Borenstein, Jeffrey

AU - Tearney, Guillermo J.

AU - Bouma, Brett E.

AU - De Boer, Johannes F.

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