Fluid replacement following dehydration reduces oxidative stress during recovery

Il Young Paik; Myung Hyun Jeong; Hwa Eun Jin; Young Il Kim; Ah Ram Suh; Su Youn Cho; Hee Tae Roh; Chan Ho Jin; Sang Hoon Suh

doi:10.1016/j.bbrc.2009.03.135

Fluid replacement following dehydration reduces oxidative stress during recovery

Il Young Paik, Myung Hyun Jeong, Hwa Eun Jin, Young Il Kim, Ah Ram Suh, Su Youn Cho, Hee Tae Roh, Chan Ho Jin, Sang Hoon Suh

Department of Physical Education

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

To investigate the effects of hydration status on oxidative DNA damage and exercise performance, 10 subjects ran on a treadmill until exhaustion at 80% VO_2max during four different trials [control (C), 3% dehydration (D), 3% dehydration + water (W) or 3% dehydration + sports drink (S)]. Dehydration significantly decreased exercise time to exhaustion (D < C and S). Plasma MDA levels were significantly higher at pre-exercise in D than C. Plasma TAS was significantly lower at pre-exercise in C and S than in D, and was significantly lower in S than D at 60 min of recovery. Dehydration significantly increased oxidative DNA damage during exercise, but fluid replacement with water or sports drink alleviated it equally. These results suggest that (1) dehydration impairs exercise performance and increases DNA damage during exercise to exhaustion; and (2) fluid replacement prolongs exercise endurance and attenuates DNA damage.

Original language	English
Pages (from-to)	103-107
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	383
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2009.03.135
Publication status	Published - 2009 May 22

Bibliographical note

Funding Information:
The authors thank the subjects for their time and effort during this study. We also thank the members of the exercise physiology, and food and nutrition laboratories at Yonsei University for their laboratory support throughout this study. We are especially grateful to Dr. Xiaocai Shi for his support. This study was supported by a grant from the Gatorade Sports Science Institute.

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2009.03.135

Cite this

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title = "Fluid replacement following dehydration reduces oxidative stress during recovery",

abstract = "To investigate the effects of hydration status on oxidative DNA damage and exercise performance, 10 subjects ran on a treadmill until exhaustion at 80% VO2max during four different trials [control (C), 3% dehydration (D), 3% dehydration + water (W) or 3% dehydration + sports drink (S)]. Dehydration significantly decreased exercise time to exhaustion (D < C and S). Plasma MDA levels were significantly higher at pre-exercise in D than C. Plasma TAS was significantly lower at pre-exercise in C and S than in D, and was significantly lower in S than D at 60 min of recovery. Dehydration significantly increased oxidative DNA damage during exercise, but fluid replacement with water or sports drink alleviated it equally. These results suggest that (1) dehydration impairs exercise performance and increases DNA damage during exercise to exhaustion; and (2) fluid replacement prolongs exercise endurance and attenuates DNA damage.",

author = "Paik, {Il Young} and Jeong, {Myung Hyun} and Jin, {Hwa Eun} and Kim, {Young Il} and Suh, {Ah Ram} and Cho, {Su Youn} and Roh, {Hee Tae} and Jin, {Chan Ho} and Suh, {Sang Hoon}",

note = "Funding Information: The authors thank the subjects for their time and effort during this study. We also thank the members of the exercise physiology, and food and nutrition laboratories at Yonsei University for their laboratory support throughout this study. We are especially grateful to Dr. Xiaocai Shi for his support. This study was supported by a grant from the Gatorade Sports Science Institute.",

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doi = "10.1016/j.bbrc.2009.03.135",

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Fluid replacement following dehydration reduces oxidative stress during recovery. / Paik, Il Young; Jeong, Myung Hyun; Jin, Hwa Eun; Kim, Young Il; Suh, Ah Ram; Cho, Su Youn; Roh, Hee Tae; Jin, Chan Ho; Suh, Sang Hoon.

In: Biochemical and Biophysical Research Communications, Vol. 383, No. 1, 22.05.2009, p. 103-107.

Research output: Contribution to journal › Article › peer-review

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AU - Jeong, Myung Hyun

AU - Jin, Hwa Eun

AU - Kim, Young Il

AU - Suh, Ah Ram

AU - Cho, Su Youn

AU - Roh, Hee Tae

AU - Jin, Chan Ho

AU - Suh, Sang Hoon

N1 - Funding Information: The authors thank the subjects for their time and effort during this study. We also thank the members of the exercise physiology, and food and nutrition laboratories at Yonsei University for their laboratory support throughout this study. We are especially grateful to Dr. Xiaocai Shi for his support. This study was supported by a grant from the Gatorade Sports Science Institute.

PY - 2009/5/22

Y1 - 2009/5/22

N2 - To investigate the effects of hydration status on oxidative DNA damage and exercise performance, 10 subjects ran on a treadmill until exhaustion at 80% VO2max during four different trials [control (C), 3% dehydration (D), 3% dehydration + water (W) or 3% dehydration + sports drink (S)]. Dehydration significantly decreased exercise time to exhaustion (D < C and S). Plasma MDA levels were significantly higher at pre-exercise in D than C. Plasma TAS was significantly lower at pre-exercise in C and S than in D, and was significantly lower in S than D at 60 min of recovery. Dehydration significantly increased oxidative DNA damage during exercise, but fluid replacement with water or sports drink alleviated it equally. These results suggest that (1) dehydration impairs exercise performance and increases DNA damage during exercise to exhaustion; and (2) fluid replacement prolongs exercise endurance and attenuates DNA damage.

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Fluid replacement following dehydration reduces oxidative stress during recovery

Abstract

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