Fluid replacement following dehydration reduces oxidative stress during recovery

Il Young Paik, Myung Hyun Jeong, Hwa Eun Jin, Young Il Kim, Ah Ram Suh, Su Youn Cho, Hee Tae Roh, Chan Ho Jin, Sang Hoon Suh

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


To investigate the effects of hydration status on oxidative DNA damage and exercise performance, 10 subjects ran on a treadmill until exhaustion at 80% VO2max during four different trials [control (C), 3% dehydration (D), 3% dehydration + water (W) or 3% dehydration + sports drink (S)]. Dehydration significantly decreased exercise time to exhaustion (D < C and S). Plasma MDA levels were significantly higher at pre-exercise in D than C. Plasma TAS was significantly lower at pre-exercise in C and S than in D, and was significantly lower in S than D at 60 min of recovery. Dehydration significantly increased oxidative DNA damage during exercise, but fluid replacement with water or sports drink alleviated it equally. These results suggest that (1) dehydration impairs exercise performance and increases DNA damage during exercise to exhaustion; and (2) fluid replacement prolongs exercise endurance and attenuates DNA damage.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - 2009 May 22

Bibliographical note

Funding Information:
The authors thank the subjects for their time and effort during this study. We also thank the members of the exercise physiology, and food and nutrition laboratories at Yonsei University for their laboratory support throughout this study. We are especially grateful to Dr. Xiaocai Shi for his support. This study was supported by a grant from the Gatorade Sports Science Institute.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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