Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection

Jaemoon Yang, Eun Kyung Lim, Hong Jae Lee, Joseph Park, Sang Cheon Lee, Kwangyeol Lee, Ho Geun Yoon, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2O4 magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.

Original languageEnglish
Pages (from-to)2548-2555
Number of pages8
JournalBiomaterials
Volume29
Issue number16
DOIs
Publication statusPublished - 2008 Jun 1

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All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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