Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2O4 magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.
|Number of pages||8|
|Publication status||Published - 2008 Jun|
Bibliographical noteFunding Information:
This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (M10755020001-07N5502-00110, R15-2004-024-00000-0 and R01-2006-000-10023-0), the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0620190-1).
All Science Journal Classification (ASJC) codes
- Ceramics and Composites
- Mechanics of Materials