FlyNet: A versatile network prioritization server for the Drosophila community

Junha Shin, Sunmo Yang, Eiru Kim, Chan Yeong Kim, Hongseok Shim, Ara Cho, Hyojin Kim, Sohyun Hwang, Jung Eun Shim, Insuk Lee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Drosophila melanogaster (fruit fly) has been a popular model organism in animal genetics due to the high accessibility of reverse-genetics tools. In addition, the close relationship between the Drosophila and human genomes rationalizes the use of Drosophila as an invertebrate model for human neurobiology and disease research. A platform technology for predicting candidate genes or functions would further enhance the usefulness of this long-established model organism for gene-to-phenotypemapping. Recently, the power of network prioritization for gene-to-phenotype mapping has been demonstrated in many organisms. Here we present a network prioritization server dedicated to Drosophila that covers ∼95% of the coding genome. This server, dubbed Fly-Net, has several distinctive features, including (i) prioritization for both genes and functions; (ii) two complementary network algorithms: direct neighborhood and network diffusion; (iii) spatiotemporal-specific networks as an additional prioritization strategy for traits associated with a specific developmental stage or tissue and (iv) prioritization for human disease genes. FlyNet is expected to serve as a versatile hypothesis-generation platform for genes and functions in the study of basic animal genetics, developmental biology and human disease. FlyNet is available for free at http://www.inetbio.org/flynet.

Original languageEnglish
Pages (from-to)W91-W97
JournalNucleic acids research
Volume43
Issue numberW1
DOIs
Publication statusPublished - 2015 Jan 1

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All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Shin, J., Yang, S., Kim, E., Kim, C. Y., Shim, H., Cho, A., Kim, H., Hwang, S., Shim, J. E., & Lee, I. (2015). FlyNet: A versatile network prioritization server for the Drosophila community. Nucleic acids research, 43(W1), W91-W97. https://doi.org/10.1093/nar/gkv453