Follicular variant of papillary thyroid carcinoma with B-type RafV600E showing higher frequency of suspicious sonographic features and multifocality

Dong Yeob Shin, Kwang Joon Kim, Sooyun Chang, Hyunki Kim, Sena Hwang, Wonjin Kim, Jaehyun Bae, Seulkee Park, Sang Wook Kang, Woong Youn Chung, Eun Jig Lee

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Abstract

Background The purpose of this study was to investigate the correlation between B-type Raf (BRAF) kinase mutation and clinicopathological features of follicular variant of papillary thyroid carcinoma (PTC). Methods Eighty-four patients with pathologically confirmed follicular variant of PTC, who underwent a preoperative BRAFV600E study, were analyzed. Clinicopathological parameters and ultrasonographic features were compared between the BRAFV600E-positive and negative groups. Results A total of 41.7% of the patients showed BRAFV600E. The BRAFV600E-positive group showed the smaller tumor size (7.3±3.6 mm vs 10.7±8.9 mm; p=.018) and the more frequent multifocality (25.7% vs 8.2%; p=.028). Follicular variant of PTC with BRAFV600E showed suspicious ultrasonographic features (88.6% vs 57.1%; p=.002) more frequently. BRAFV600E positivity is associated with multifocality after adjusting for age, sex, the presence of suspicious ultrasonographic features, pathological tumor size, and thyrotropin level. Conclusion BRAFV600E was correlated with smaller tumor size and suspicious ultrasonographic features in follicular variant of PTC. BRAFV600E was a significant parameter for predicting multifocality of follicular variant of PTC.

Original languageEnglish
Pages (from-to)1590-1595
Number of pages6
JournalHead and Neck
Volume37
Issue number11
DOIs
Publication statusPublished - 2015 Nov

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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    Shin, D. Y., Kim, K. J., Chang, S., Kim, H., Hwang, S., Kim, W., Bae, J., Park, S., Kang, S. W., Chung, W. Y., & Lee, E. J. (2015). Follicular variant of papillary thyroid carcinoma with B-type RafV600E showing higher frequency of suspicious sonographic features and multifocality. Head and Neck, 37(11), 1590-1595. https://doi.org/10.1002/hed.23793